Daniel w. Pack, Ph. D

Department of Chemical Engineering, California Institute of Technology, June 5, 2003.

Department of Bioengineering, University of Illinois, Urbana-Champaign, March 6, 2003.

Department of Materials Science and Engineering, University of Illinois, Urbana-Champaign, November 11, 2002.

Institute for Medicine and Engineering, University of Pennsylvania, October 15, 2002.

5.Department of Chemical Engineering, University of Illinois, 1999

6.Department of Chemical Engineering, Texas A&M University, 1999

7.Department of Chemical Engineering, University of Notre Dame, 1999

8.Department of Chemical Engineering, University of Connecticut, 1999

9.Department of Chemical Engineering, University of Michigan, 1999

Invited Presentations at Conferences, Symposia, and Workshops

10.“Hybrid Virus/Polymer and Virus/Lipid Gene Delivery Vectors.” 14^th Asia Pacific Confederation of Chemical Engineering, Singapore, February 22, 2012.

11.[Plenary] “Development of Virus/Polymer Chimeras as Gene Delivery Vectors.” AIChE Annual Meeting, Minneapolis, MN, October 18, 2011.

12.“Influence of Uptake Pathway on Polymer-Mediated DNA and siRNA Delivery.” AIChE Annual Meeting, Minneapolis, MN, October 18, 2011.

13.“(Re)Engineering Gene Delivery: Toward Construction of Artificial Viruses.” BIT 2^nd World Congress of Gene 2008, Guangzhou, China, December 6, 2008.

14.“(Re)Engineering Gene Delivery.” National Academy of Engineering 2008 Frontiers of Engineering Symposium, Albuquerque, NM, September 19, 2008.

15.“(Re)Engineering of Gene Delivery Vectors.” International Conference on Materials for Advanced Technologies 2007, Singapore, July 4, 2007.

16.“Overcoming Delivery Challenges in Gene Therapy.” Drug Delivery 2007, San Diego, CA, June 7, 2007.

17.“Hybrid Viral/Synthetic Gene Delivery Nanovectors: Toward an Artificial Virus.” Center for Nanoscale Science and Technology Nanotechnology Workshop, Urbana, IL, May 5, 2007.

18.“Precision Particle Fabrication for Controlled-Release Drug Delivery.” Design of Medical Devices Conference (sponsored by the University of Minnesota Biomedical Engineering Institute and Department of Mechanical Engineering), Minneapolis, MN, April 18, 2007

19.“Polymeric Gene Delivery: Design and Synthesis.” Celebrating Thirty Years of Robert Langer's Science, Boston, MA, July 15, 2006.

20. “Precise Microparticle Fabrication for Control of Drug Delivery Kinetics.” Particles 2002, Orlando, Florida, April 22, 2002.

5. “Precision Polymer Microparticles for Controlled-Release Drug Delivery.” 223^rd American Chemical Society National Meeting, Orlando, Florida, April 9, 2002.

6. i-emerging, University of Illinois, October 25, 2001.

7. BioPharm Conference 1999, Framingham, MA, June 9, 1999 and Burlingame, CA, June 16, 1999.

8. 
   Distinguished Graduate Student Lecture, California Institute of Technology, April 23, 1996.
   

Invited Presentations to Private Industry and Government Laboratories

21.“Toward Advanced Gene and Drug Delivery Systems.” Abbott Laboratories, Abbott Park, IL, April 7, 2006.

22.“Toward Advanced Gene and Drug Delivery Systems.” 3M, Minneapolis, MN, December 9, 2004

23.“Precision-Release Drug Delivery.” ALZA, Mountain View, CA, August 11, 2004

24.“Precision-Release Drug Delivery.” 3M, Minneapolis, MN, January 13, 2004.

9. “(Re)Engineering of Polymeric Gene Delivery Vectors: Mechanisms of Intracellular Trafficking.” Merck, West Point, PA, February 20, 2003.

10. “Precision Particle Fabrication: Applications in Drug Delivery.” Eastman Chemical Company, Kingsport, TN, May 20, 2002.

11. “A Versatile Technology for Precisely Controlled Microsphere Fabrication.” Advanced Inhalation Research, Cambridge, MA, November 3, 2000.

12. “A Versatile Technology for Precisely Controlled Microsphere Fabrication.” Alkermes, Cambridge, MA, August 15, 2000.

13. 
    Bristol-Myers Squibb Company, Hopewell, NJ, February 17, 1999.
    
14. 
    Naval Research Laboratory, Biomolecular and Biosystems Science and Technology Division, July 26, 1993.
    

Contributed Papers at Conferences, Symposia and Workshops

25.V.W.T. Shum and D.W. Pack “Effect of Uptake Pathway On Non-Viral Gene Delivery in Vitro and in Vivo.” AIChE Annual Meeting, Pittsburgh, PA, October, 2012.

26.A.N. Ford Versypt, D.W. Pack and R.D. Braatz, “Modeling of Drug Delivery From PLGA Microspheres Using Reaction-Diffusion Equations with Hindered Diffusion.” AIChE Annual Meeting, Pittsburgh, PA, October, 2012.

27.Y. Xia and D.W. Pack, “Uniform Double-Wall Microspheres for Zero-Order Protein Delivery.” American Association of Pharmaceutical Scientists Annual Meeting, Chicago, IL, October, 2012.

28.Y. Xia and D.W. Pack, “Uniform Biodegradable Double-Wall Microspheres for Protein Delivery.” 16^th Annual Conference of the Chinese-American Chemical Society, Great Lakes Chapter, Evanston, IL, May, 2012.

29.R.K. Keswani and D.W. Pack, “Recovery of Retroviral Infectivity via Non-Covalent Attachment of Chitosan to Murine Leukemia Virus-Like Particles.” AIChE Annual Meeting, Minneapolis, MN, October, 2011.

30.R.K. Keswani, M. Lazebnik and D.W. Pack, “Reinstatement of Retroviral Infectivity via Non-Covalent Attachment of DOTAP, DOPE and Cholesterol to Murine Leukemia Virus-Like Particles.” AIChE Annual Meeting, Minneapolis, MN, October, 2011.

31.A.N. Ford Versypt, D.W. Pack and R.D. Braatz, “Modeling of Dynamic Hindered Diffusion of Drugs from Biodegradable PLGA Microspheres with Evolving Porous Structure.” AIChE Annual Meeting, Minneapolis, MN, October, 2011.

32.Q. Xu, D.W. Pack and C.-H. Wang, “Effect of fabrication conditions on the formation of double-walled microspheres and microfibers by coaxial electrospraying/electrospinning technique.” AIChE Annual Meeting, Salt Lake City, UT, November, 2010.

33.Q. Xu, C.-H. Wang and D.W. Pack, “Combined modality doxorubicin-based chemotherapy and chitosan-mediated p53 gene therapy using double-walled microspheres for cancer treatment.” AIChE Annual Meeting, Salt Lake City, UT, November, 2010.

34.K.M. Smith and D.W. Pack, “Characterization of protein stability and release in monodisperse poly(lactide-co-glycolide) microspheres.” AIChE Annual Meeting, Salt Lake City, UT, November, 2010.

35.X. Zhu, D.W. Pack and R.D. Braatz, “Intravascular delivery from drug-eluting stents: effect of anisotropic diffusivity and drug loading on arterial drug distribution.” AIChE Annual Meeting, Salt Lake City, UT, November, 2010.

36.A.N. Ford, D.W. Pack and R.D. Braatz, “Design of PLGA microparticle drug delivery systems using a reaction-diffusion model.” AIChE Annual Meeting, Salt Lake City, UT, November, 2010.

37.V.S. Shum and D.W. Pack, “Utilizing shRNA and novel polymeric materials to optimize in vivo cancer-targeted gene therapy.” 2^nd Annual Controlled Release Society Illinois Student Chapter Symposium, Chicago, IL, May, 2010.

38.M.E. Hwang, W. Gunther and D.W. Pack, “Successful Gene Delivery with Receptor-Targeted PAMAM Dendrimers Occurs Via Caveolae-Mediated Uptake” 13^th Annual Meeting of the American Society of Gene and Cell Therapy, Washington, D.C., May, 2010.

39.R. Keswani, M.E. Hwang and D.W. Pack, “Interplay of clathrin and caveolin trafficking pathways in polymer-based gene delivery.” 13^th Annual Meeting of the American Society of Gene and Cell Therapy, Washington, D.C., May, 2010.

40.M.E. Hwang and D.W. Pack, “Elucidating structure-function relationship of primary amines in cationic polymer gene delivery vehicles.” 12^th Annual Meeting of the American Society of Gene Therapy, San Diego, California, May, 2009

41.M. Kishida, A.N. Ford, D.W. Pack and R.D. Braatz, “Optimal control of cellular uptake in tissue engineering.” University of Illinois Interdisciplinary Conference, Urbana, IL, January, 2009

42.L. Wong and D.W. Pack, “High efficiency siRNA-mediated knockdown using high-molecular-weight branched polyethylenimine in mammalian cells.” AIChE Annual Meeting, Philadelphia, PA, November, 2008.

43.N.P. Gabrielson and D.W. Pack, “Efficient polyethylenimine-mediated gene delivery proceeds via caveolae-mediated uptake in HeLa cells.” AIChE Annual Meeting, Philadelphia, PA, November, 2008.

44.A.N. Ford, D.W. Pack, and R.D. Braatz, “Multiscale modeling of polymer microsphere drug delivery.” AIChE Annual Meeting, Philadelphia, PA, November, 2008.

45.A.N. Ford, D.W. Pack and R.D. Braatz, “Modeling drug delivery for design of PLGA microparticles.” AIChE Annual Meeting, Philadelphia, PA, November, 2008.

46.A.N. Ford, D.W. Pack, and R.D. Braatz. “A mechanistic modeling approach to the design and evaluation of polymeric drug delivery systems.” AIChE Annual Meeting, Philadelphia, PA, November, 2008.

47.R.K. Keswani, D.M. Drake and D.W. Pack, “Design of Hybrid/Viral Gene Therapy vectors via association of murine leukemia viruses with synthetic agents.” AIChE Midwest Regional Conference, Chicago, IL, September, 2008.

48.D.M. Drake and D.W. Pack, “Active Intracellular Transport of Polyethylenimine/DNA Polyplexes.” AIChE Annual Meeting, Salt Lake City, UT, November, 2007.

49.N.K. Varde and D.W. Pack, “Monte Carlo Model of Biodegradable Polymer Microsphere Erosion and Drug Release.” AIChE Annual Meeting, Salt Lake City, UT, November, 2007.

50.M. Kishida, A.N. Ford, D.W. Pack, and R.D. Braatz. “Optimal control of cellular uptake rate in tissue scaffolds.” AIChE Annual Meeting, Salt Lake City, November, 2007.

51.A.N. Ford, D.W. Pack and R.D. Braatz, “Modeling autocatalytic controlled-release drug delivery from PLGA microspheres.” AIChE Annual Meeting, Salt Lake City, UT, November, 2007.

52.L. Wong and D.W. Pack, “Efficient siRNA Delivery with Acetylated Polyethylenimine.” AIChE Annual Meeting, San Francisco, CA, November, 2006.

53.J.D. Ramsey, H. Vu and D.W. Pack, “Construction of Hybrid Viral/Synthetic Gene Delivery Nanovectors.” AIChE Annual Meeting, San Francisco, CA, November, 2006.

54.J.D. Ramsey and D.W. Pack, “Converting Non-Infectious Virus-Like Particles into Hybrid Gene Therapy Vectors Using Polyethylenimine.” American Society of Gene Therapy’s 9^th Annual Meeting, St. Louis, MO, June, 2006.

1. 
   H. Vu and D.W. Pack, “Enhanced Stability of Retrovirus by Directed Evolution.” AIChE Annual Meeting, Cincinnati, OH, October, 2005.
   
2. 
   N.K. Varde, K. Kim and D.W. Pack, “DNA Release from Aqueous Core/Polymer Shell Microcapsules.” AIChE Annual Meeting, Austin, TX, November, 2004.
   
3. 
   C. Raman, K. Kim and D.W. Pack, “Effect of Microsphere Diameter on Protein and Oligonucleotide In-Vitro Release Kinetics.” AIChE Annual Meeting, Austin, TX, November, 2004.
   
4. 
   N. Gabrielson and D.W. Pack, “Investigation of the Mechanism of Enhanced Gene Delivery by Acetylated PEI.” AIChE Annual Meeting, Austin, TX, November, 2004.
   

55.N. Gabrielson, M.L. Forrest and D.W. Pack, “Reduction of Polyethylenimine Buffering Capacity Enhances In-Vitro Gene Delivery Activity.” American Society of Gene Therapy 7^th Annual Meeting, Minneapolis, MN, June, 2004.

5. 
   M.L. Forrest, J.T. Koerber, and D.W. Pack, “Enhancement of PEI-Mediated Gene Delivery by Acetylation of Primary and Secondary Amines.” AIChE Annual Meeting, San Francisco, CA, November, 2003.
   
6. 
   C. Berkland, K. Kim, and D.W. Pack, “Controlled Release from Uniform Two-Polymer Microcapsules.” 30^th International Symposium on Controlled Release of Bioactive Materials, Glasgow, Scotland, June, 2003.
   

56.L. Forrest, J.T. Koerber, D.W. Pack, “Non-Viral Gene Delivery Vectors Based on Modified Polyethylenimine.” 30^th International Symposium on Controlled Release of Bioactive Materials, Glasgow, Scotland, June, 2003.

57.L. Forrest, J.T. Koerber, D.W. Pack, “Highly Efficient, Biodegradable Polyethylenimine Gene Delivery Vehicles.” 30^th International Symposium on Controlled Release of Bioactive Materials, Glasgow, Scotland, June, 2003.

15.