Daniel w. Pack, Ph. D

D.W. Pack, “Biochemical Elucidation of the Mechanisms of Intracellular Polyplex Trafficking.” AIChE Annual Meeting, Indianapolis, IN, November, 2002.

C. Berkland, K. Kim, and D.W. Pack, “Precision Microcapsules with Controlled Diameter and Shell Thickness.” 29^th International Symposium on Controlled Release of Bioactive Materials, Seoul, Korea, July, 2002.

L. Forrest and D.W. Pack, “Quantitation of Endolysosomal Trafficking of Polyplex Gene Delivery Vehicles.” 28^th International Symposium on Controlled Release of Bioactive Materials, San Diego, California, June, 2001.

L. Forrest and D.W. Pack, “Quantitative Assay for Polyplex Release from Endolysosomes: Implications for Design of Gene Delivery Vehicles.” AIChE Annual Meeting, Los Angeles, CA, November, 2000.

D.W. Pack, K. Kim and C. Berkland, “Fabrication of PLGA Microspheres with Precisely Controlled, Homogeneous Size Distribution.” 27^th International Symposium on Controlled Release of Bioactive Materials, Paris, France, July, 2000.

D.W. Pack, D.A. Putnam and R. Langer, “Design of New 'Proton-Sponge' Biopolymers for Gene Therapy.” AIChE Annual Meeting, Miami, FL, November, 1998.

D.W. Pack, K. Ng, K.M. Maloney and F.H. Arnold, “Ligand-Induced Reorganization and Protein Assembly in Synthetic Metal-Chelating Lipid Membranes.” Materials Research Society Fall Meeting, Boston, MA, November 27 - December, 1995.

D.W. Pack, D.R. Shnek, D.Y. Sasaki and F.H. Arnold, “Specific Protein Targeting to Metal-Chelating Artificial Lipid Membranes via Metal Coordination.” AIChE Annual Meeting, San Francisco, CA, November, 1994.

RESEARCH GRANTS RECEIVED

Received:

1. 
   National Institutes of Health (1R01GM085222), “Effects of Uptake Mechanism on Polyplex Design Criteria.” 07/09 – 04/13, $1,253,120.
   
2. 
   Siteman Center for Cancer Nanotechnology Excellence, “Tumor-Targeting of Nanoparticle Gene Delivery Vehicles.” 01/08 – 12/08, $18,360.
   
3. 
   Parkinson’s Disease Foundation, “Targeted Polymer Nanoparticles for Brain Drug Delivery.” 07/06 – 06/08, $40,000.
   
4. 
   National Science Foundation (BES 0602636), “Construction of Hybrid Viral/Synthetic Gene Delivery Nanovectors.” 6/06 – 5/09, $270,000.
   
5. 
   National Institutes of Health (1 R01 EB005181), “Precision Microparticles for Controlled Protein Delivery.” 4/06 – 1/11, $1,035,557.
   
6. 
   American Cancer Society, “Design of Materials for Delivery of Small-Interfering RNA.” 1/05 – 12/09, $600,000.
   
7. 
   American Heart Association Grant-in-Aid, “New Polymers for Cardiovascular Gene Delivery.” 07/04 – 06/06, $132,000.
   
8. 
   3M Research Grant in Aid, “Precision Drug Delivery Systems.” 02/03 – 02/06, $45,000.
   
9. 
   National Institutes of Health (EB002878), “Design of Microparticles for Precision Drug Delivery.” 09/03 – 08/05, $358,589.
   
10. 
    National Science Foundation, Faculty Early Career Development (CAREER) Award, “Quantitative Polyplex Structure-Function Relationships for Design of Artificial Viruses.” 07/02 – 06/08, $375,000.
    
11. 
    National Science Foundation, “Quantitation of polyplex structure-function relationships.” 09/01 – 08/02, $99,812.
    
12. 
    American Heart Association, “Design of Artificial Viruses for Cardiovascular Gene Therapy.” 7/01 – 6/04, $247,500.
    
13. 
    American Chemical Society Petroleum Research Fund, “Methods for rational design of gene delivery polymers.” 3/01 – 08/03, $25,000.
    
14. 
    Alkermes, Inc., “Precisely controlled fabrication of uniform PLGA microspheres.” 02/01 – 01/03, $175,741.
    
15. 
    Roy J. Carver Charitable Trust, “Directed evolution of viruses for human gene therapy: borrowing nature’s strategies to generate new medicines.” 11/00 – 12/04, $350,000.
    
16. 
    University of Illinois Campus Research Board, “A new technique for advanced biodegradable polymer micro- and nanoparticle fabrication.” 5/00 – 5/01, $12,880.
    
17. 
    University of Illinois Campus Research Board, “Directed evolution of murine leukemia virus envelope protein for improved gene delivery.” 4/99 – 3/00, $25,005.
    

SERVICE

Editorships/Reviewer of Journals or Other Learned Publications

Editorial Board, Journal of Controlled Release January 2006-present

Ad hoc reviewer for:
ACS Nano, Acta Biomaterialia, Advanced Drug Delivery Reviews, Advanced Materials, AIChE Journal, Bioconjugate Chemistry, Biomacromolecules, Biomaterials, Bioorganic & Medicinal Chemistry, Biopolymers, Biotechnology and Bioengineering, Cancer Chemotherapy and Pharmacology, Crit. Rev. Ther. Drug Carr. Syst., Drug Delivery and Industrial Pharmacy, Expert Opinion on Drug Delivery, European J. of Pharmaceutics and Biopharmaceutics, Gene Therapy, Human Gene Therapy, Industrial and Engineering Chemistry, Interface, The Royal Society, Journal of Biomedical Materials Research, Journal of Colloids and Surfaces, Journal of Combinatorial Chemistry, Journal of Controlled Release, Journal of Gene Medicine, Journal of Pharmaceutical Sciences, Journal of Pharmacy and Pharmacology, Journal of Physical Chemistry, Journal of the American Chemical Society, Langmuir, Macromolecular Bioscience, Macromolecules, Microfluidics and Nanofluidics, Molecular Pharmaceutics, Molecular Therapy, Nature Materials, Pharmaceutical Research, Proc. Natl. Acad. Sci USA., Progress in Polymer Science, Trends in Immunology

Review Panels

NIH, Gene and Drug Delivery study section, permanent member July 2010-June 2014

NIH, National Center for Cancer Nanotechnology Excellence Special
Emphasis Panel February 2010

NIH, Gene and Drug Delivery study section, Ad-hoc member October 2009

National Institutes of Health, ARRA Challenge Grants Panel 4, Bioengineering
Sciences and Technology study section June 2009

National Institutes of Health, Bioanalytical and Biophysical Measurements

study section, Ad-hoc member April 2009

National Institutes of Health, Special Emphasis Panel study section,

Ad-hoc member July 2008

American Heart Association Bioengineering and Biotechnology

Peer Review Study Group April 2008

NSF, IGERT review panel December 2007

NIH, Kidney, Urologic and Hematologic Diseases D study section
Ad-hoc member June 2007

NIH, Nanoscience and Nanotechnology in Biology and Medicine

study section, Ad-hoc member May 2006

Nanotechnology Institute (Pennsylvania) reviewer May 2005

Council for Chemical Sciences of the Netherlands Organization for
Scientific Research (NOW), Ad-hoc member April 2005

NSF, NSEC site visit review team, Ohio State University April 2005

Kentucky Science and Engineering Foundation, R&D Excellence Program April 2005

NIH, Gene and Drug Delivery study section, Ad-hoc member November 2004

American Heart Association Bioengineering and Biotechnology
Peer Review Study Group October 2004

NIH, Gene and Drug Delivery study section, Ad-hoc member July 2004

American Heart Association Bioengineering and Biotechnology
Peer Review Study Group April 2004

NIH, Gene and Drug Delivery study section, Ad-hoc member March 2004

NSF SBIR/STTR Phase I, Drug Delivery II April 2003

American Chemical Society, Petroleum Research Fund August 2001, April 2003

NSF CAREER, Biochemical Engineering section November 2002

NSF CAREER, Biomedical Engineering section January 2001

Service to Disciplinary and Professional Societies and Associations

Scientific Advisory Board, 2^nd World Congress of Gene, Guangzhou, China 2008

Chair, Area 15d/e Programming Committee, AIChE Annual Meeting 2008

Jorge Heller Journal of Controlled Release-Elsevier Outstanding Paper Award

Committee, Controlled Release Society 2007-2012

Vice-Chair, Area 15d/e Programming Committee, AIChE Annual Meeting 2007

CRS-3M Outstanding Inhalation or Transdermal Drug Delivery Paper Graduate Student/Post Doc Award Committee, Controlled Release Society 2006-2007

Director, Food, Pharmaceutical and Bioengineering Division, AIChE 2006-2008

Chair, Engineering Approaches in Gene Delivery Symposium,
AIChE Annual Meeting 2005

Abstract Reviewer, Molecular Conjugates Symposium, 7^th Annual Meeting of the

American Society of Gene Therapy 2004

3M-Controlled Release Society Graduate Student Award Committee 2003-2006

Vice-Chair, Novel Carriers for Drug and Cell Delivery Symposium,
AIChE Annual Meeting 2002

Chair, Young Faculty Forum, AIChE Annual Meeting 2002

Vice-Chair, Carriers in Gene Therapy Symposium,
AIChE Annual Meeting 2001

Vice-Chair, Young Faculty Forum, AIChE Annual Meeting 2001

University/Campus Service

University of Kentucky

Nanobiotechnology Center Steering Committee 2012

Graduate Committee, CME 2012

University of Illinois, Urbana-Champaign

Director of Graduate Studies, ChBE 2011-2012

College of Engineering Executive Committee 2010-2012

Chair, Graduate Affairs & Recruiting, ChBE 2010-2011

Alumni Development Committee 2009-2011

Senior Staff Committee, ChBE 2009-2012

Director Search Committee, School of Chemical Sciences 2005

Department Head Search Committee, ChBE 2005

Engineering-Biology/Chemistry Liaison Committee,
College of Engineering 2005-2007

Executive Committee, School of Chemical Sciences 2005-2008

Staff Committee, ChBE 2005-2012

Chair, Graduate Affairs & Recruiting, ChBE 2005-2008

UIUC Faculty Senate, ChBE representative 2005-2007

Committee on Admissions and Academic Standards

College of Liberal Arts & Sciences 2004-2006

Cell & Tissue Engineering Faculty Search Committee

Department of Bioengineering 2003-2005

Chair, Biomolecular and Chemical Engineering curriculum committee,

ChBE 2001-2005

American Institute of Chemical Engineers Student Chapter Advisor 2001-2004

Graduate Admissions Committee, ChBE 1999-2000, 2001-2005

Department Brochure/Web Page Committee, ChBE 2000-2007

Undergraduate Advising Committee, ChBE 1999-2012

Administrative Committee, ChBE 1999-2012

Executive Committee, Cell and Molecular Biology Training Grant 1999-2003

Consulting

Nanodisc, Inc. 2005-2006

Abbott Labs 2005-2012

Intradigm, Scientific Advisory Board 2007-2011

Orbis Bioscience, Scientific Advisory Board 2008-present

Professional Activities

American Institute of Chemical Engineers, member 1992-present

Controlled Release Society, member 1998-present

Society for Biological Engineering, member 2004-present

RESIDENT INSTRUCTION

Supervision of Ph.D. Students

1. 
   Cory J. Berkland, Ph.D., 2003, “Control of Micro- and Nano-Sphere Size Distributions: Implications in Drug Delivery.” now Associate Professor of Pharmaceutical Chemistry and Chemical and Petroleum Engineering, University of Kansas.
   

58.M. Laird Forrest, Ph.D., 2003, “Engineering of Non-Viral Vectors for Gene Therapy.” now Assistant Professor of Pharmaceutical Chemistry, University of Kansas.

59.Emily J. Pollauf, Ph.D., 2005, “Characterization of Biodegradable Polymeric Microparticles for Controlled-Release Drug Delivery.” now at University of Colorado.

60.Chandrashekar Raman, Ph.D., 2005, “Modeling Drug Delivery from Polymer Microspheres.” now at Momentive Performance Materials.

61.Halong N. Vu, Ph.D., 2006, “Engineering Viruses for Improved Stability: Isolating and Characterizing a Stable Mutant of Murine Leukemia Virus.” now Scientist, Monsanto.

62.Joshua D. Ramsey, Ph.D., 2006, “Hybrid Gene Therapy Vectors Comprised of Synthetic Polymer and Noninfectious Virus-Like Particles.” now Assistant Professor, Oklahoma State University.

63.Neelesh K. Varde, Ph.D., 2007, “Elucidation of Drug Release Mechanisms in PLGA Microspheres.” now Business Development Coordinator, Roquette America.

64.Nathan P. Gabrielson, Ph.D., 2009, “Elucidation of Design Criteria for Non-Viral Gene Delivery Vector Development: Intracellular Processing.” now Post-Doc, University of Illinois.

65.Shy Chyi Wuang, Ph.D. 2009, “Functionalization of Magnetic Nanoparticles for Bio-Applications.” now GEM4 Post-Doctoral Fellow, National University of Singapore.

66.David M. Drake, Ph.D., 2009, “Biochemical Investigation of the Intracellular Trafficking of Non-Viral and Hybrid Gene Therapy Vectors.”

67.Lily S. Wong, Ph.D., 2009, “Elucidation of Design Criteria For siRNA Delivery in Mammalian Cells Using Polyethylenimine.” now Engineer, OSIsoft.

68.Kalena D. Stovall, Ph.D., 2009, “Investigation of Properties Affecting Controlled Release of Macromolecules from PLGA Microspheres.” now Engineer/Scientist, Exponent.

69.Kara M. Smith, Ph.D., 2011, “Investigation of Protein Destabilization in Monodisperse Poly(Lactide-co-Glycolide) Microparticles.” now Technical Service Scientist, Henkel Corp.

70.Mark Hwang, Ph.D., 2012, “Interplay of Clathrin and Caveolar Trafficking in Non-Viral Gene Delivery via Receptor-Targeting Polymers.” now Medical Student, University of Illinois.

71.Rahul K. Keswani, Ph.D., 2012, “Design of Hybrid Retroviral/Synthetic Gene Delivery Vectors.” now Process Engineer, Orochem.

Supervision of M.S. Students

1. 
   Cory J. Berkland, M.S., 2001, “Methods of Controlling Size Distribution of Polymeric Drug Delivery Particles.”
   
2. 
   M. Laird Forrest, M.S., 2001, “Quantitation of Polyplex pH Microenvironment as a Tool for Elucidating Gene Delivery Mechanism.”
   
3. 
   Halong N. Vu, M.S., 2002, “Engineering of Viruses for Human Gene Therapy: Directed Evolution of Retrovirus Envelope Protein for Increased Stability.”
   
4. 
   Shashank A. Virkar, M.S., 2002, “Using FRET to Detect Dissociation of DNA-Polymer Complexes for Gene Delivery.”
   
5. 
   Joshua D. Ramsey, M.S., 2003, “Directed Evolution of the Moloney Murine Leukemia Virus for Retargeting to Human Cells.”
   
6. 
   Neelesh K. Varde, M.S., 2003, “Modeling of Controlled Release from Biodegradable Polymer Microcapsules.”
   
7. 
   David M. Drake, M.S., 2004, “Elucidation of Intracellular Trafficking of Polyethylenimine Gene Therapy Vectors.”
   
8. 
   Nathan P. Gabrielson, M.S., 2004, “Enhanced Gene Delivery Through Reduction of Polyethylenimine Buffering Capacity.”
   
9. 
   Lily Wong, M.S., 2005, “Elucidation of Design Criteria for Non-Viral siRNA Vectors.”
   
10. 
    Stephen M. Anthony, M.S., 2006, “Polymeric Nanoparticles for Brain Drug Delivery.”
    
11. 
    Kalena D. Stovall, M.S., 2007, “pH Microenvironment Inside Degrading Polymer Microspheres.”
    
12. 
    Kara M. Smith, M.S. 2008, “Characterization of Protein Stability and Release from Uniform Biodegradable Polymeric Microspheres.”
    
13. 
    Rahul K. Keswani, M.S. 2009, “Design of Viral/Polymer and Viral/Lipid Hybrid Gene Therapy Vectors.”
    
14. 
    Mark E. Hwang, M.S. 2009, “Structure-Function Relationships for Polyamidoamine Dendrimer Vector Design.”
    
15. 
    Wing Tat Victor Shum, M.S. 2010, “The Effects of PVP(Fe(III)) Catalyst and Molecular Weight on Gene Delivery Efficiency and Uptake of Biodegradable Crosslinked Polyethylenimine.”
    
16. 
    Yujie Xia, M.S. 2011, “Uniform Double Wall Microspheres/Microcapsules for Protein Delivery.”
    
17. 
    Mihael Lazebnik, M.S. 2012, “On the Endocytosis of Poly- and Lipoplexes in siRNA Delivery in Hela Cells.”
    

Service on Ph.D. Examination Committees

UIUC:
Antonios K. Doufas, Timothy J. Pricer, Jessica Desnoyer, John D. Faull, Cory J. Berkland (chair), Matthew W. Liberatore, Arvind Sankaran, M. Laird Forrest (chair), Amy Balija (Chemistry), Emily J. Pollauf (chair), Chandrashekar Raman (chair), Jennifer Heemstra (Chemistry), Anil Prakasam, Halong Vu (chair), Christian, Josh Ramsey (chair), Ananth Bhoj, Neelesh Varde (chair), Ankur Agarwal, Linda Hasadsri (Cell and Developmental Biology), Erin Elliott (Chemistry), Chao Wang (Chemistry), Richie Kohman (Chemistry), Tyler Johannes, Wenjuan Zha, Cynthia Mann, Nathan Gabrielson (chair), Minjie Xu, Jonathan Silvestre, Matthew Langer, Zengyi Shao, Keng Jin Lee, Ashlee Ford Versypt, David M. Drake (chair), Shy Chyi Wuang (chair), Ryan Sullivan, Fei Wen, Hong Jin, Kalena Stovall (chair), Teresa Fraterman (Chemistry), Lily Wong (chair), Ashish Kapoor, Kara Smith (chair), Kevin Lin, Cathy Chu, Jing Du, Qingxing Noel Xu (chair), Rahul Keswani (chair), Mo Jiang, Yuki Kimura, Khushnuma Koita, Michael Rasche, John Schmidt, Jaeyun Sung, Xiaoxiang Zhu, Yunzi Luo, Wing Tat Victor Shum (chair), Maryam Sayyah.

Other Institutions:
Jeremy Daniel Lease, Natl. Univ. Singapore; Chen Wenhui, Natl. Univ. Singapore

Courses Taught

CHBE 121 – The Chemical Engineering Profession 2008

CHBE 221 – Introduction to Chemical Engineering 2002-2004, 2006, 2009-2011

CHBE 422 – Mass Transfer Operations 2007, 2012

CHBE 424 – Chemical Reaction Engineering 2006, 2010, 2011

CHBE 430 – Unit Operations Laboratory 1999-2001

CHBE 431 – Synthesis and Design of Chemical Systems 1999-2001

CHBE 471 – Introduction to Biochemical Engineering 2000-2008

Updated: 6/23/2017