Daniel w. Pack, Ph. D

DANIEL W. PACK, Ph.D.

University of Kentucky phone: [phone]

Department of Chemical and Materials Engineering fax: [phone]

Department of Pharmaceutical Sciences

467 Biological Pharmaceutical Bldg. email: [e-mail]

789 South Limestone Street

Lexington, KY 40536-0596

EDUCATION

1997 Ph.D., Chemical Engineering, California Institute of Technology, Pasadena

1990 B.S. (summa cum laude), Chemical Engineering, University of Illinois, Urbana-Champaign

PROFESSIONAL EXPERIENCE

2012-present Ashland Inc. Chair in Chemical Engineering

2012-present Professor of Chemical & Materials Engineering and Pharmaceutical Sciences, University of Kentucky

2009-2012 Professor of Chemical and Biomolecular Engineering, University of Illinois

2007-2012 Affiliate Faculty, Institute for Genomic Biology, University of Illinois

2006- 2012 Affiliate Faculty, Beckman Institute, University of Illinois

2005-2009 Associate Professor of Chemical and Biomolecular Engineering, University of Illinois

2004- 2012 Affiliate Faculty, Department of Bioengineering, University of Illinois, Urbana-Champaign

2003- 2012 Research Faculty, Center for Nanoscale Science and Technology, University of Illinois, Urbana-Champaign

2000- 2012 Biotechnology Center Faculty, University of Illinois, Urbana-Champaign

2000-2004 Faculty of Bioengineering, University of Illinois, Urbana-Champaign

1999-2005 Assistant Professor of Chemical and Biomolecular Engineering, University of Illinois, Urbana-Champaign

1996-1998 Post-Doctoral Research Fellow, Massachusetts Institute of Technology

AWARDS AND HONORS

2008 Xerox Award for Faculty Research, College of Engineering, University of Illinois, Urbana-Champaign

2007 Multi-Year Faculty Achievement Award, College of Engineering, University of Illinois, Urbana-Champaign

2007 Engineering Council Award for Excellence in Advising, University of Illinois, Urbana-Champaign

2006 Alumni Discretionary Award, College of Liberal Arts and Sciences, University of Illinois, Urbana-Champaign

2006 Engineering Council Award for Excellence in Advising, University of Illinois, Urbana-Champaign

2004-2005 Beckman Fellow, Center for Advanced Study, University of Illinois, Urbana-Champaign

2004 Controlled Release Society/Genencor Outstanding Consumer & Diversified Products Paper Award

2003-2006 3M Young Faculty Award

2003 Excellence in Teaching Award, School of Chemical Sciences, University of Illinois, Urbana-Champaign

2002-2007 Faculty Early Career Development (CAREER) Award, National Science Foundation

2000 Incomplete List of Teachers Ranked as Excellent by Their Students, Fall 2000, University of Illinois, Urbana-Champaign

2000 Excellence in Teaching Award, School of Chemical Sciences, University of Illinois, Urbana-Champaign

2000 Collins Scholar, Academy for Excellence in Engineering Education, University of Illinois, Urbana-Champaign

1997-1999 National Institutes of Health Post-doctoral Fellowship, Massachusetts Institute of Technology

1996 Distinguished Graduate Student Lectureship, California Institute of Technology

1995 Materials Research Society Graduate Student Award

1991-1994 Landau Fellowship, California Institute of Technology

1990 University Scholar, University of Illinois

1990 Senior Alumni Award (Chemical Engineering), University of Illinois

PUBLICATIONS

Peer-Reviewed Publications (h-index = 30)

1. 
   M. Kishida, A. Ford-Versypt, D.W. Pack and R.D. Braatz (2012) “Optimal control of 1D cellular uptake in tissue engineering.” submitted.
   
2. 
   A.N. Ford Versypt, D.W. Pack and R.D. Braatz (2012) “Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres—a review.” in press.
   
3. 
   X. Zhu, D.W. Pack and R.D. Braatz (2012) “Modeling intravascular delivery from drug-eluting stents with biodurable coating: investigation of anisotropic vascular drug diffusivity and arterial drug distribution.” Computer Methods in Biomechanics and Biomedical Engineering, in press. PMCID: PMC3442148
   
4. 
   Q. Xu, C.-H. Wang and D.W. Pack (2012) “Monodisperse double-walled microspheres loaded with chitosan-p53 nanoparticles and doxorubicin for combined gene therapy and chemotherapy.” Journal of Controlled Release 163, 130-135.
   
5. 
   V.W.T. Shum, N.P. Gabrielson, M.L. Forrest and D.W. Pack (2012) “The effects of PVP(Fe(III)) catalyst on polymer molecular weight and gene delivery via biodegradable cross-linked polyethylenimine.” Pharmaceutical Research 29, 500-510. PMCID: PMC3465843
   
6. 
   A. Barnard, P. Posocco, S. Pricl, M. Calderon, R. Haag, M.E. Hwang, V.W.T. Shum, D.W. Pack and D.K. Smith (2011) “Degradable self-assembling dendrons for gene delivery – experimental and theoretical insights into the barriers to cellular uptake.” Journal of the American Chemical Society 133, 20288-20300.
   
7. 
   S.C. Wuang, K.G. Neoh, E.T. Kang, D.E. Leckband and D.W. Pack (2011) “Acid-sensitive magnetic nanoparticles as potential drug depots.” AIChE Journal 57, 1638-1645. PMCID: PMC3134249
   
8. 
   S. Jones, N. Gabrielson, C.-H. Wong, H.-F. Chow, D.W. Pack, P. Posocco, M. Fermeglia, S. Pricl, and D. Smith (2011) “Hydrophobically modified DNA binding dendrons – developing structure-activity relationships for DNA binding and gene transfection.” Molecular Pharmaceutics 8, 416-429.
   
9. 
   D.M. Drake, R.K. Keswani and D.W. Pack (2010) “Effect of serum on transfection by polyethylenimine/virus-like particle hybrid gene delivery vectors.” Pharmaceutical Research 27, 2457-2465.
   
10. 
    Q. Xu, C.-H. Wang and D.W. Pack (2010) “Polymeric carriers for gene delivery: chitosan and poly(amidoamine) dendrimers.” Current Pharmaceutical Design 16, 2350-2368. PMCID: PMC3471158
    
11. 
    J.D. Ramsey, H.N. Vu and D.W. Pack (2010) “A top-down approach for construction of hybrid polymer-virus gene delivery vectors.” Journal of Controlled Release 144, 39-45.
    
12. 
    N.P. Gabrielson and D.W. Pack (2009) “Efficient polyethylenimine-mediated gene delivery proceeds via a caveolar pathway in HeLa cells.” Journal of Controlled Release 136, 54-61.
    
13. 
    J.G. Hardy, C.S. Love, N.P. Gabrielson, D.W. Pack and D.K. Smith (2009) “Synergistic effects on gene delivery – co-formulation of small disulfide-linked dendritic polycations with lipofectAMINE 2000.” Organic and Biomolecular Chemistry 7, 789-793.
    
14. 
    C.J. Park, N.P. Gabrielson, D.W. Pack, R.D. Jamison and A.J. Wagoner-Johnson (2009) “Chitosan-neutrophil interactions induce neutrophil migration via IL-8.” Biomaterials 30, 436-444.
    
15. 
    S.P. Jones, N.P. Gabrielson, D.W. Pack and D.K. Smith (2008) “Synergistic effects in gene delivery – A structure-activity approach to the optimisation of hybrid dendritic-lipidic transfection agents.” Chemical Communications 2008, 4700-4702.
    
16. 
    H. Hosseinkhani, M. Hosseinkhani, N.P. Gabrielson, D.W. Pack, A. Khademhosseini and H. Kobayashi (2008) “DNA nanoparticles encapsulated in 3-D tissue engineered scaffolds enhance osteogenic differentiation of mesenchymal stem cells.” Journal of Biomedical Materials Research Part A 85A, 47-60.
    
17. 
    S.C. Wuang, K.G. Neoh, E.-T. Kang, D.W. Pack and D.E. Leckband (2008) “HER-2-mediated endocytosis of magnetic nanospheres and the implications in cell targeting and particle magnetization.” Biomaterials 29, 2270-2279. PMCID: PMC2312094
    
18. 
    D.M. Drake and D.W. Pack (2008) “Biochemical investigation of active intracellular transport of polymeric gene-delivery vectors.” Journal of Pharmaceutical Science 97, 1399-1413.
    
19. 
    H.N. Vu, J.D. Ramsey and D.W. Pack (2008) “Engineering of a stable retroviral gene delivery vector by directed evolution.” Molecular Therapy 16, 308-314.
    
20. 
    N.K. Varde and D.W. Pack (2007) “Influence of particle size and antacid on release and stability of plasmid DNA from uniform PLGA microspheres.” Journal of Controlled Release 124, 172-180. PMCID: PMC2141539
    
21. 
    S.C. Wuang, K.G. Neoh, E.-T. Kang, D.W. Pack and D.E. Leckband (2007) “Synthesis and functionalization of polypyrrole-Fe3O4 nanoparticles for applications in biomedicine.” Journal of Materials Chemistry 17, 3354-3362.
    
22. 
    C. Berkland, E.J. Pollauf, C. Raman, R. Silverman, K. Kim and D.W. Pack (2007) “Macromolecule release from monodisperse PLG microspheres: control of release rates and investigation of release mechanism.” Journal of Pharmaceutical Science 96, 1176-1191.
    
23. 
    C. Berkland, E.J. Pollauf, N.K. Varde, D.W. Pack and K. K. Kim (2007) “Monodisperse liquid-filled biodegradable microcapsules.” Pharmaceutical Research 24, 1007-1013.
    
24. 
    S.C Wuang, K.G. Neoh, E.-T. Kang, D.W. Pack and D.E. Leckband (2007) “Polypyrrole Nanospheres with Magnetic and Cell-Targeting Capabilities.” Macromolecular Rapid Communications 28, 816-821.
    
25. 
    N.P. Gabrielson and D.W. Pack (2006) “Acetylation of polyethylenimine enhances gene delivery via weakened polymer/DNA interactions.” Biomacromolecules 7, 2427-2435.
    
26. 
    S.C Wuang, K.G. Neoh, E.-T. Kang, D.W. Pack and D.E. Leckband (2006) “Heparinized magnetic nanoparticles: in-vitro assessment for biomedical applications.” Advanced Functional Materials 16, 1723-1730.
    
27. 
    E.J. Pollauf and D.W. Pack (2006) “Use of thermodynamic parameters for design of polymer/polymer microcapsule systems.” Biomaterials 27, 2898-2906.
    
28. 
    J.G. Hardy, M.A. Kostiainen, D.K. Smith, N.P. Gabrielson and D.W. Pack (2006) “Dendrons with spermine surface groups as potential building blocks for non-viral vectors in gene therapy.” Bioconjugate Chemistry 17, 172-178.
    
29. 
    E.J. Pollauf, C. Berkland, K. Kim and D.W. Pack (2005) “In vitro degradation of polyanhydride/polyester core-shell double-wall microspheres.” International Journal of Pharmaceutics 301, 294-303.
    
30. 
    E.J. Pollauf, K. Kim and D.W. Pack (2005) “Small-molecule release from poly(d,l-lactide)/poly(d,l-lactide-co-glycolide) composite microparticles.” Journal of Pharmaceutical Science 94, 2013-2022.
    
31. 
    D.W. Pack, A.S. Hoffman, S. Pun and P. Stayton (2005) “Design and development of polymeric gene delivery vectors.” Nature Reviews Drug Discovery 4, 581-593. [selected New Hot Paper for November 2006 by Thomson Scientific:
    http://www.esi-topics.com/nhp/2006/november-06-DanielWPack.html]
    
32. 
    C. Raman, C. Berkland, K. Kim and D.W. Pack (2005) “Modeling small-molecule release from PLG microspheres: effects of polymer degradation and non-uniform drug distribution.” Journal of Controlled Release 103, 149-158.
    
33. 
    M.L. Forrest, N. Gabrielson and D.W. Pack (2005) “Cyclodextrin-polyethylenimine conjugates for targeted in vitro gene delivery.” Biotechnology and Bioengineering 89, 416-423.
    
34. 
    C. Berkland, A. Cox, K. Kim and D.W. Pack (2004) “Three-month, zero-order piroxicam release from monodisperse double-walled microspheres of controlled shell thickness.” Journal of Biomedical Materials Research 70A, 576-584.
    
35. 
    C. Berkland, D.W. Pack and K. Kim (2004) “Controlling surface nano-structure using flow-limited field-injection electrostatic spraying (FFESS) of poly(d,l-lactide-co-glycolide).” Biomaterials 25, 5649-5658.
    
36. 
    C. Berkland, E. Pollauf, D.W. Pack and K. Kim (2004) “Uniform double-walled polymer microcapsules of controllable shell thickness.” Journal of Controlled Release 96, 101-111.
    
37. 
    M.L. Forrest, G.E. Meister, J.T. Koerber and D.W. Pack (2004) “Partial acetylation of polyethylenimine enhances in vitro gene delivery.” Pharmaceutical Research 21, 365-371.
    
38. 
    C. Berkland, K. Kim and D. W. Pack (2004) “Precision polymer microparticles for controlled release drug delivery.” ACS Symposium Series 879, 197-213.
    
39. 
    N.K. Varde and D.W. Pack (2004) “Microspheres for controlled-release drug delivery.” Expert Opinion on Biological Therapy 4, 35-51.
    
40. 
    C. Berkland, M.J. Kipper, B. Narasimhan, K. Kim and D.W. Pack (2004) “Microsphere size, precipitation kinetics and drug distribution control drug release from biodegradable polyanhydride microspheres.” Journal of Controlled Release 94, 129-141.
    
41. 
    M.L. Forrest, J.T. Koerber and D.W. Pack (2003) “A degradable, non-toxic polyethylenimine derivative for highly efficient gene delivery.” Bioconjugate Chemistry 14, 934-940.
    
42. 
    C. Berkland, K. Kim and D.W. Pack (2003) “PLG microsphere size controls drug release rate through several competing factors.” Pharmaceutical Research 20, 1055-1062.
    
43. 
    C. Berkland, M. King, A. Cox, K. Kim and D.W. Pack (2002) “Precise control of PLG microsphere size provides enhanced control of drug release rate.” Journal of Controlled Release 82, 137-147.
    
44. 
    M.L. Forrest and D.W. Pack (2002) “On the kinetics of polyplex endocytic trafficking: implications for gene delivery vector design.” Molecular Therapy 6, 57-66.
    
45. 
    C. Berkland, K. Kim and D.W. Pack (2001) “Fabrication of PLG microspheres with precisely controlled and monodisperse size distributions.” Journal of Controlled Release 73, 59-74.
    
46. 
    D. Putnam, C. Gentry, D.W. Pack and R. Langer (2001) “Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini.” Proc. Natl. Acad. Sci., USA 98, 1200-1205.
    
47. 
    K. Fu, D.W. Pack, A.M. Klibanov and R. Langer (2000) “Visual evidence of acidic environment within degrading PLGA microspheres.” Pharmaceutical Research 17, 100-106.
    
48. 
    D.W. Pack, D. Putnam and R. Langer (2000) “Design of imidazole-containing endosomolytic biopolymers for gene delivery.” Biotechnology and Bioengineering 67, 217-223.
    
49. 
    K.M. Maloney, W.R. Schief, D.W. Pack, W. Frey, F.H. Arnold and V. Vogel (1999) “Binding and two-dimensional crystallization of streptavidin at the air-water interface via engineered Cu-IDA chelator lipids.” Coordination Chemistry Reviews 183, 3-18.
    
50. 
    S. Ando, D. Putnam, D.W. Pack and R. Langer (1999) “PLGA microspheres containing plasmid DNA: preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization.” Journal of Pharmaceutical Sciences 88, 126-130.
    
51. 
    D.W. Pack, G. Chen, K.M. Maloney, C.-T. Chen and F.H. Arnold (1997) “A metal-chelating lipid for 2D protein crystallization via coordination of surface histidines..” Journal of the American Chemical Society 119, 2479-2487.
    
52. 
    D.W. Pack and F.H. Arnold (1997) “Langmuir monolayer characterization of metal-chelating lipids for protein targeting to membranes.” Chemistry and Physics of Lipids 86, 135-152.
    
53. 
    D.W. Pack, K. Ng, K.M. Maloney and F.H. Arnold (1997) “Ligand-induced reorganization and assembly in synthetic lipid membranes.” Supramolecular Science, 4, 3-10.
    
54. 
    W.F. Frey, W.R. Schief, D.W. Pack, C.-T. Chen, A. Chilkoti, P. Stayton, V. Vogel and F.H. Arnold (1996) “Two-dimensional protein crystallization via metal-ion coordination by naturally occurring surface histidines.” Proceedings of the National Academy of Sciences, USA 93, 4937-4941
    
55. 
    K. Ng, D.W. Pack, D.Y. Sasaki and F.H. Arnold (1995) “Engineering protein-lipid interactions: targeting of histidine-tagged proteins to metal-chelating lipid monolayers.” Langmuir 11, 4048-4055.
    
56. 
    D.Y. Sasaki, D.R. Shnek, D.W. Pack and F.H. Arnold (1995) “Metal-induced dispersion of lipid aggregates: A simple, selective and sensitive fluorescent metal ion sensor.” Angewandte Chemie, International Edition in English 34, 905-907.
    
57. 
    D.R. Shnek, D.W. Pack, D.Y. Sasaki and F.H. Arnold (1994) “Specific protein attachment to artificial membranes via coordination to lipid-bound copper(II).” Langmuir 10, 2382-2388.
    
58. 
    S. Mallik, S.D. Plunkett, P.K. Dhal, R.D. Johnson, D.W. Pack, D.R. Shnek and F.H. Arnold (1994) “Towards materials for the specific recognition and separation of proteins.” New Journal of Chemistry 18, 299-304.
    

Non-Peer-Reviewed Publications

59. 
    D.W. Pack (2004) “Timing is everything.” Nature Materials 3, 133-134.
    

Book Chapters

60. 
    K.K. Kim and D.W. Pack (2006) “Microspheres for Drug Delivery.” in BioMEMS and Biomedical Nanotechnology Volume 1: Biological and Biomedical Nanotechnology, (M. Ferrari, A.P. Lee and L.J. Lee, Eds.), pp. 19-50, Springer, New York.
    
61. 
    D.W. Pack (2002) “Gene Delivery Polymers.” in Encyclopedia of Polymer Science and Technology, 3^rd Ed., (H.F. Mark and J.I. Kroschwitz, Eds.), John Wiley & Sons, Inc., New York.
    

Abstracts and Proceedings

62. 
    Q. Xu, C.-H. Wang and D.W. Pack, “Combined Modality Doxorubicin-Based Chemotherapy and Chitosan-Mediated p53 Gene Therapy Enhances Inhibition of Hepatocellular Carcinoma HepG2 Cell Growth.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 39 (2012).
    
63. 
    Q. Xu, S.E. Chin, C.-H. Wang and D.W. Pack, “In Vitro Degradation of Double-Walled PLA(PLGA) Microspheres.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 39 (2012).
    
64. 
    M.E. Hwang, W. Gunther and D.W. Pack, “Successful Gene Delivery with Receptor-Targeted PAMAM Dendrimers Occurs Via Caveolae-Mediated Uptake.” Molecular Therapy 20:S155 (2012).
    
65. 
    Q. Xu, C.-H. Wang and D.W. Pack, “Encapsulation of Doxorubicin and Chitosan-p53 Nanoparticles in Monodispersed Double-Walled Microspheres.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 38 (2011).
    
66. 
    Q. Xu, B.S. Wong, D.W. Pack and C.-H. Wang, “Controlling Morphology and Size of Double-Walled Microspheres from Coaxial Electrospraying.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 38 (2011).
    
67. 
    M. Kishida, D.W. Pack and R.D. Braatz, “State-Constrained Optimal Spatial Field Control for Controlled Release in Tissue Engineering.” Proceedings of the American Control Conference. Baltimore, MD, 1766 (2010).
    
68. 
    M. Hwang, W. Gunther and D.W. Pack, “Elucidating Structure Function Relationship of Primary Amines in Cationic Polymer Gene Delivery Vehicles.” Molecular Therapy 17:S337 (2009).
    
69. 
    S.C. Wuang, K.G. Neoh, E.T. Kang, D.W. Pack and D.E. Leckband, “Targeting Breast Cancer Cells via HER-2-Mediated Endocytosis.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 35 (2008).
    
70. 
    K.D. Stovall and D.W. Pack, “Investigation of the Effect of Microsphere Size on the Internal pH of Degrading PLGA Microspheres.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 35 (2008).
    
71. 
    M. Kishida, A. N. Ford, D. W. Pack, and R. D. Braatz, “Optimal Control of Cellular Uptake in Tissue Engineering.” Proceedings of the American Control Conference. Seattle, WA, 2118-2123 (2008).
    
72. 
    D.M. Drake and D.W. Pack, “Biochemical Investigation of Intracellular Transport of Polyethylenimine/DNA Polyplexes.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 34, 601 (2007)
    
73. 
    N.K. Varde and D.W. Pack, “Encapsulation and Release of Plasmid DNA from Uniform PLGA Microspheres.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 34, 526 (2007)
    
74. 
    J.D. Ramsey and D.W. Pack, “A Viral/Non-Viral Hybrid Gene Therapy Vector.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 33, 596 (2006).
    
75. 
    J.D. Ramsey and D.W. Pack, “Converting Non-Infectious Virus-Like Particles into Hybrid Gene Therapy Vectors Using Polyethylenimine.” Molecular Therapy 13:S416 (2006).
    
76. 
    A.M. Balija, M.L. Forrest, D.W. Pack, S.C. Zimmerman, “Dendritic Trojan horse.” Abstracts of Papers of the American Chemical Society 228:U63 (2004).
    
77. 
    C. Raman, C. Berkland, K.K. Kim, D.W. Pack, “Modeling Small-Molecule Release from PLG Microspheres: Effect of Polymer Degradation and Non-Uniform Drug Distribution.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 31, 719 (2004).
    
78. 
    E.J. Pollauf, C. Berkland, K.K. Kim, D.W. Pack, “Degradation of Microcapsules Composed of Bulk- and Surface-Eroding Polymers.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 31, 616 (2004).
    
79. 
    C. Berkland, K.K. Kim, D.W. Pack, “Protein Release from Uniform Poly(D,L-lactide-co-glycolide) Microspheres.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 31, 472 (2004).
    
80. 
    Y. Choy, H. Choi, C. Berkland, D.W. Pack, K.K. Kim, “Release Profiles from Uniform Ethyl Cellulose Microspheres with Different Sizes and Molecular Weights.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 31, 417 (2004).
    
81. 
    C. Berkland, E. Pollauf, K.K. Kim, D.W. Pack, “Modulating Protein Release from Monodisperse Aqueous-Core Microcapsules with Defined PLG Shell.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 31, 344 (2004).
    
82. 
    N.K. Varde, K.K. Kim, D.W. Pack, “DNA Release from Uniform Polymer Microspheres and Microcapsules.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 31, 261 (2004).
    
83. 
    M.L. Forrest, N. Gabrielson, D.W. Pack, “Reduction of polyethylenimine buffering capacity enhances in-vitro gene delivery activity.” Molecular Therapy 9:S138 (2004).
    
84. 
    L. Forrest, J.T. Koerber, D.W. Pack, “Highly Efficient, Biodegradable Polyethylenimine Gene Delivery Vehicles.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 30, 588 (2003).
    
85. 
    L. Forrest, J.T. Koerber, D.W. Pack, “Non-Viral Gene Delivery Vectors Based on Modified Polyethylenimine.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 30, 587 (2003).
    
86. 
    C. Berkland, K. Kim, and D.W. Pack, “Controlled Release from Uniform Two-Polymer Microcapsules.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 30, 350 (2003).
    
87. 
    Y. Choy, C. Berkland, H. Choi, D.W. Pack, and K. Kim, “Fabrication and Characterization of Uniform Ethyl Cellulose Microspheres for Use as Advanced Drug Delivery Vehicles.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 30, 236 (2003).
    
88. 
    C. Berkland, K. Kim, and D.W. Pack, “Fabrication of Uniform Microcapsules Exhibiting Controlled Shell Thickness.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 30, 20 (2003).
    
89. 
    C. Berkland, K. Kim, and D.W. Pack, “Modulation of Release Profiles Through Microsphere Size Control.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 29, 301 (2002).
    
90. 
    C. Berkland, K. Kim, and D.W. Pack, “Precision Microcapsules with Controlled Diameter and Shell Thickness.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 29, 198 (2002).
    
91. 
    C. Berkland, Y. Choy, D.W. Pack, and K. Kim, “Computer-Controlled Fabrication of Microspheres and Microcapsules of Precise Size and Size Distribution Using Mechanical, Hydrodynamic, and Electrical Forces.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 29. 63 (2002).
    
92. 
    D.W. Pack, C. Berkland, N. Varde, K. Kim, “Precision polymer microshells for controlled-release drug delivery.” Abstracts of Papers of the American Chemical Society 223:U442 (2002).
    
93. 
    L. Forrest and D.W. Pack, “Quantitation of endolysosomal trafficking of polyplex gene delivery vehicles.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 28, 607 (2001).
    
94. 
    D.W. Pack, K. Kim and C. Berkland, “Fabrication of PLGA microspheres with precisely controlled, homogeneous size distribution.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 27 1130-1131 (2000).
    
95. 
    K. Fu, D.W. Pack, A. Laverdiere, S. Son, and R. Langer, “Visualization of pH in degrading polymer microspheres.” Proceedings of the International Symposium on Controlled Release of Bioactive Materials 25, 150–151 (1998).
    

PATENTS

1. 
   K. Kim, D.W. Pack, C. Berkland, “Microparticles.” U.S. patent application 12/016,592
   
2. 
   K. Kim, D.W. Pack, C. Berkland, “Microparticles.” U.S. patent application 11/939,262
   
3. 
   H.N. Vu, D.W. Pack, J.D. Ramsey, “Stable retrovirus and methods of use.” U.S. patent 7,485,446.
   
4. 
   K. Kim, D.W. Pack, C. Berkland, “Microparticles.” U.S. patent 7,368,130.
   
5. 
   K. Kim, D.W. Pack, C. Berkland, “Microparticles.” U.S. patent 6,669,961; PCT application WO 02/13786 A2.
   
6. 
   D.W. Pack, D.A. Putnam, R. Langer, “Cell delivery compositions.” U.S. patent 6,692,911.
   
7. 
   D.Y. Sasaki, D.R. Shnek, D.W. Pack and F.H. Arnold, “Lipid-based metal sensor.” U.S. patent 5,616,790.
   

PRESENTATIONS

Invited University Presentations

1. 
   Department of Chemical and Biochemical Engineering, University of Iowa, November 15, 2012.
   
2. 
   Center for Translational Targeted Therapeutics and Nanomedicine, University of Pennsylvania, September 19, 2012.
   
3. 
   Department of Bioengineering, University of Washington, April 17, 2011.
   
4. 
   Department of Molecular Medicine and Gene and Virus Therapy Program, Mayo Clinic, April 5, 2012.
   
5. 
   Department of Chemical and Materials Engineering and Department of Pharmaceutical Sciences, University of Kentucky, December 16, 2011.
   
6. 
   School of Chemical Engineering, Oklahoma State University, November 29, 2011.
   
7. 
   Department of Biopharmaceutics, University of Illinois, Chicago, September 28, 2011.
   
8. 
   Department of Bioengineering, Rice University, October 19, 2010.
   
9. 
   Department of Chemical and Petroleum Engineering, University of Pittsburgh, April 15, 2010.
   
10. 
    School of Mechanical, Aerospace, Chemical and Materials Engineering, Arizona State University, March 5, 2010.
    
11. 
    Department of Polymer Science and Engineering, University of Massachusetts, Amherst, October 2, 2009.
    
12. 
    Department of Chemical Engineering, Texas A&M University, April 1, 2009.
    
13. 
    Department of Pharmacology, University of Illinois, Chicago, March 4, 2009.
    
14. 
    Department of Biomedical Engineering, Yale University, November 7, 2008.
    
15. 
    Department of Chemical and Biomolecular Engineering, University of Tennessee, Knoxville, October 14, 2008.
    
16. 
    Center for Biochemical and Biophysical Studies, Northern Illinois University, October 3, 2008.
    
17. 
    Siteman Cancer Center, School of Medicine, Washington University, April 10, 2008.
    
18. 
    School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, March 12, 2008.
    
19. 
    Department of Pathobiology, University of Illinois, February 6, 2008.
    
20. 
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, March 12, 2007.
    
21. 
    Department of Radiation and Cellular Oncology, University of Chicago, February 26, 2007.
    
22. 
    Department of Chemical Engineering, University of California, Santa Barbara, October 20, 2005
    

1.Department of Pharmaceutical Chemistry, University of Kansas, April 19, 2005.

2.Department of Chemical and Biomolecular Engineering, University of Illinois, September 21, 2004.

3.Department of Chemical and Biological Engineering, University of Wisconsin, February 10, 2004.

4.Department of Chemical and Biomolecular Engineering, Cornell University, February 2, 2004.