Smallpox Presentation


Life Threatening Vaccine Reactions



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SmallpoxMonkeypox

Life Threatening Vaccine Reactions

  • Center for Food Security and Public Health Iowa State University - 2004
  • Postvaccinal encephalitis
    • 3 per million vaccinees
      • 40% fatal
      • Permanent neurological damage
  • Eczema vaccinatum

Military U.S. Vaccination Campaign

  • Center for Food Security and Public Health Iowa State University - 2004
  • December 2002-January 2004
  • 578,286 military vaccinees
    • 71% primary vaccinees
  • 30 suspected cases of contact transfer to other people
  • Data as of Feb 13, 2004; MMWR

2003 U.S. Vaccination Campaign

  • Center for Food Security and Public Health Iowa State University - 2004
  • January 24-December 31, 2003
  • 39,213 civilian vaccinees
    • 11 cases of inadvertent inoculation
    • 1 case of generalized vaccinia
    • 97 serious events
    • 712 nonserious events
      • Rash, fever, pain, headache, fatigue
    • Myocarditis/pericarditis
  • Data as of Feb 13, 2004; MMWR

2003 U.S. Vaccination Campaign

  • Center for Food Security and Public Health Iowa State University - 2004
  • 2003, more cardiac related reactions than expected
  • 1947, compared to NYC vaccinations
  • Defer vaccine with 3 or more cardiac risk factors
    • Current smoker/tobacco user, high blood pressure, high cholesterol or triglycerides, high blood sugar, heart condition before age 50 in a parent, brother or sister

Monkeypox: The Agent

  • Center for Food Security and Public Health Iowa State University - 2004
  • Orthopoxvirus, related to smallpox
  • Transmission
    • Reservoir may be African squirrel
    • Bites, aerosol, direct contact
    • Zoonotic, animal-to-animal, person-to-person
  • Animals: Fever, rash, pustules conjunctivitis
  • Humans: Flu-like, rash, pustules, lymphadenopathy

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