Сборник содержит материалы научной мультиконференции «Биотех- нология медицине будущего»

Polish experience in clinical phage application
Ryszard Międzybrodzki
1,2,3
, Wojciech Fortuna
1,4
, Sławomir Letkiewicz
1,5
, Paweł Rogóż
1
, 
Beata Weber-Dąbrowska
1,2
, Andrzej Górski
1,2,3
1
 phage Therapy Unit, Hirszfeld Institute of Immunology and Experimental Therapy,
polish Academy of Sciences, Wrocław, poland 
2
Bacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, 
polish Academy of Sciences, Wrocław, poland 
3
Department of Clinical Immunology, Transplantation Institute,
Medical University of Warsaw, Warsaw, poland 
4
Regenerative and Functional Neurosurgery Unit, Department of Neurosurgery,
Wroclaw Medical University, Wrocław, poland 
5
Jan Długosz University in Częstochowa, poland
Poland belongs to pioneers of the phage therapy (PT) and its tradition of the phage appli-
cation in treatment of bacterial infections started just a few years after the World War I and 
was continued after the World War II. Although Hirszfeld Institute has provided preparations 
for PT and coordinated it throughout Poland since the late 1960s and according to the Polish 
regulations PT is still considered as an experimental treatment. In 2005 we have opened a Phage 
Therapy Unit – the first such center in European Union, where we admit on an out-patient 
basis patients with different chronic bacterial infections not responding to antibiotic treatment 
under the rules of a therapeutic experiment. Since that time we have treated for PT over 700 
patients. Our clinical results, summarized here, are promising and they confirm general and 
remote safety of the phage use. Besides, they suggest potential anti-inflammatory effect of 
bacteriophages independent of their known antimicrobial action. They could be responsible 
for some good PT results observed in the absence of pathogen eradication.

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Всероссийская мультиконференция с международным участием «Биотехнология – медицине будущего»
29 июня - 2 июля 2019 г., г. Новосибирск, Россия
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