DIAGNOSTIC AVAILABILITY OF IGG ELISA IN HUMAN HYDATIDOSIS IN SAMARKAND, UZBEKISTAN
Suvonkulov Uktamjon Toirovich
1
, Dmitriy Kovalenko
1
, Tai-Soon Yong
2
, Yoon-Soo Jang
2
, Myeong Heon Shin
2
1
Isaev Research Institute of Medical Parasitology, Ministry of Health, Republic of Uzbekistan,
2
Department of Environmental Medical Biology, Yonsei University College of Medicine, Seoul, Republic of Korea
Hydatidosis caused by Echinococcus granulosus sensu lato (s.l.) is a public health problem in endemic countries in-
cluding Uzbekistan. Hydatid cysts in humans are located usually in the liver. This study was performed to investigate diagnostic
availability of ELISA in liver cystic echinococcosis. By ELISA using cystic fluid antigen obtained from sheep, IgG titers in 20
sera from patients (median age 11) operated in Second Clinic of Samarkand between 2016 and 2017, and in sera from 22 non-
infected persons (median age 17) were analyzed. Cut off of OD (mean+2SD) was 0.19. The present ELISA recognized 85.0%
sensitivity and 100.0% specificity. Absorbance (Mean±SD) of operated patient sera and non-infected control sera was 1.5±0.32
and 0.09±0.05, respectively. Next, 3960 residents of 3 villages including Urta Saydov, Choporashli, and Kumchuk were
screened for abdominal ultrasonography (US) and IgG ELISA. 3955 residents were found to be US negative in the abdomen,
and 5 residents were found to be cyst in the liver. Among 3955 US negative persons, only 11 persons were found be positive
by IgG ELISA. In contrast, among 5 US positive persons in liver, 4 persons showed high titer of IgG (OD range from 0.24 to
1.17). These results suggest that IgG ELISA is useful for confirmation and screening in diagnosis of liver hydatid cyst in Sa-
markand area, Uzbekistan.
PAST AND PRESENT SITUATION OF PARASITIC INFECTIONS IN KOREA
Tai-Soon Yong
Environmental Medical Biology, Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul, Korea
Objectives. To review the situation of human parasitic infections in Korea. Results. In Korea, intestinal helminths’ in-
fections were major control targets among parasitic infections historically. Almost all the people were infected at the time of the
Japanese colonial period (1910-1945), after liberation (1945), and during the Korean War (1950-53). This high rate of preva-
lence is a natural phenomenon in the past when the main industrial base in Korea was agriculture, and the manure was used
as the main fertilizer to sustain agriculture. In addition, most parasitic infections were chronic with a low mortality and asympto-
matic, so they were classified as tasks of no priority to other acute infectious diseases. Even after the war, it was unable to
carry out an effective parasite control in Korea. In 1966, the Korean government established the "Prevention Law of Parasitic
Diseases", and started the mass parasite control campaign in 1969 on the legal basis. Since 1970s, the stool examination and
treatment was conducted twice a year for students. Since 1971, the survey on the intestinal parasite infection was performed
of the whole nation every 5 to 8 years. The most recent national statistical data was obtained from the eighth survey in 2012.
According to this data, the infection rate of intestinal parasites in Korea is 2.6%. Malayan filariasis was declared to have been
eliminated in 2007. Liver fluke (Clonorchis sinensis) control has become possible since the 1980s when the effective anthel-
mintic (praziquantel) was developed and marketed. In 2004, it was confirmed that the infection rate in Korea was 2.4% showing
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