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Биология ва тиббиёт муаммолари, 2018, 3,1 (103) 147
ASPECTS OF FUNCTIONAL CHANGES IN THE GASTROINTESTINAL TRACT
Askaryants V.P. Sa
ʼ
dinov P.O, Omonova Ch.P.
Tashkent Pediatrik Medikal Institute
Annotation. The digestive system has always interested physicians of any direction and therefore in our work aspects
of functional shifts of this system are reflected on the basis of the literary analysis. New economic conditions changed ideology
of the relations between subjects of a medical care. The satisfaction of needs of consumers of medical services and introduction
few expensive technologies of diagnostics and treatment of pathological states were added to problems of decrease in indexes
of incidence and mortality, traditionally priority for domestic health care, new, including. In spite of the fact that the health care
is on the advanced positions in any state, and pediatricians and therapists work professionally and with the complete devotion,
there is a dissatisfaction of a particular part of the population with a medical care. Larger expenses of time and funds for
consultations and inspection have important social and economic value. As authors of literature note that the role of pediatri-
cians and general practitioners in treatment of many widespread diseases is underestimated that contradicts integrated ap-
proach to formation of health of children and adult population, the modern concept of health care. As authors of references note
that at the same time it is conventional that these states often have the functional nature, their roots lie in family, a way of life
and nourish. Excess inspection in these cases not only does not promote establishment of the truth, it often hides the reasons
of diseases under masks of numerous diagnoses. Also the dyspepsia syndrome which though is considered mainly functional
is not an exception of this row, in the course of inspection, as a rule, finds shape of the combined gastrointestinal pathology.
Static data showed that the peptic ulcer is one of the most often found digestive tract diseases. It is supposed that suffer from
it about 10% of the population of the earth. Clinical physicians, physiologists and pathophysiologists note in the researches that
the clinical picture and pathogenetic mechanisms of formation of a peptic ulcer of a stomach do not depend on a floor and are
characterized: a polymorphism of a pain syndrome, communication of emergence of pains with quality of food in 50% of men
and women have 41,6%, acid production as basal, and after stimulation by Pentagastrinum, a regulation of basal secretion,
reaction of parietal cages to a stress, realization of its influence on parietal cages does not differ from the data obtained in
control group. The revealed increase in maintenance of a somatostatin in a gastric juice in the conditions of an insulinic hypo-
glycemia can matter in decrease in protective function of a somatostatin in conditions a stressful situations; change of a hor-
monal hum noise testifies to dysfunction of the hypophysial and adrenal system which is shown in violation of system of the
inverse communication - secretion of AKTG is reduced in a stage of aggravation and increases in a stage of remission of a
disease, and secretion of Oestradiolum, sensitivity of somatotrof to a stressful situation (insulinichypoglycemias) - secretion of
STG increases less, than in control group increase in activity of processes is promoted by the FLOOR, to deterioration in
microcirculation and decrease of the activity of reparative processes in a stomach mucosa; at a histologic research of all patients
in antral and fundal departments of a stomach chronic gastritis, with an intestinal metaplasia in antral department is revealed.
Also analyzing data of references it is possible to note that I understand those cases of a dyspepsia when at careful gastroin-
testinal inspection, its reason does not manage to be established as the functional. By the researches conducted in recent
years it is shown that two groups of factors are the cornerstone of clinical manifestations of the functional dyspepsia: motive
gastric disturbances and duodenum and also visceral hypersensitivity. Clinical physicians noted that by means of express
research techniques at patients with a dyspepsia violation of accommodation and a rhythm of a peristalsis of a stomach, antro-
duodenal coordination and delay of evacuation from a stomach was revealed. These works are interesting from the point of
view of studying of the functional condition of a stomach at a dyspepsia, but they do not open the syndrome reasons. From
here one more name of the functional dyspepsia - essential, that is an unknown etiology. References also reflect that now
diagnostic actions at a diabetes mellitus are directed, generally on specification of a character of defeat of a mucosa of the top
departments of a digestive tube. However such approach does not promote studying out of the gastrointestinal mechanisms of
a dyspepsia and allows to carry out mainly expected treatment that causes a relapsing current of this state. Meanwhile a circle
of the pathological states capable due to humoral and neuro-reflex influences to cause the functional frustration of the top
departments of a digestive tube. Numerous data on a dyspeptic syndrome at depressions, vegetative violations are provided in
literature, food allergy, infections. Also there are enough bases to believe that treatment of these diseases in a complex with
symptomatic tools, will promote permanent knocking over of manifestations of a dyspepsia. So far as domestic authors note
that in domestic medical practice in the presence at the patient with a dyspepsia, it is accepted to think first of all of the diagnosis
of chronic gastritis or the gastroduodenit. It as a rule is exposed according to the subjective data found at a scopy research and
is a peculiar criterion at the dyspepsic manifestations any an etiology However according to the Sydney classification, chronic
gastritis is the morphological diagnosis and is verified only on the basis of studying of a mucosa of a stomach. Especially as
endoscopic and morphological changes at gastritis do not correlate with clinical manifestations of a dyspepsia in any way. And
the diagnostic and medical approaches which are carried out on the basis of such representations one-sided and often inaccu-
rate, take away the doctor from searching and elimination of the true reasons of a syndrome of a dyspepsia, causing excess
and unreasonable drug treatment. Thus, summing up the result of the literary analysis it is possible to come to a conclusion
that the gap between the modern ideas of the nature and treatment the dyspepsic of frustration and traditional, the stereotypes
accepted in medical practice. They find expression in excess gastrointestinal inspection of patients to the detriment of broad
clinical approach that promotes the considerable expenses. Introduction of the modern technologies of maintaining in broad
clinical practice will promote to upgrading of the provided medical care and will bring the considerable economic effect. Thus,
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