Липидларнинг метаболизми

Липидларнинг метаболизми

• Маърузачи: т.ф.д.
• доц. М.У.Кульманова

Кўриб чиқиладиган саволлар

• 1.Ёғ кислоталар биосинтези ва унинг бошқарилиши. Пальмитат синтетаза фермент комплекси.
• 2.Ацетосирка кислота биосинтези ва унинг физиологик ахамияти.
• 3.Холестерин тузилиши ва аҳамияти. Холестерин биосинтези ва ташилиши.
• 4.Организмнинг асосий фосфо- ва гликолипидлари, уларнинг аҳамияти.
• 5.Липидлар алмашинувининг бошқарилиши. Ёғ босиш, семириш, уларни ёшга боғлиқ хусусиятлари.
• 6.Гиперхолестеринемия ва унинг турлари, атеросклероз ривожланишининг биокимёвий асослари.
• 7.Ўт –тош касаллиги. Холестерин тошлари шаклланишинг биокимиевий асослари.

Cholesterol, the characteristic steroid alcohol of animal tissues, performs a number of essential functions in the body. For example, cholesterol is a structural component of all cell membranes, modulating their fluidity, and, in specialized tissues, cholesterol is a precursor of bile acids, steroid hormones, and vitamin D.

• Cholesterol, the characteristic steroid alcohol of animal tissues, performs a number of essential functions in the body. For example, cholesterol is a structural component of all cell membranes, modulating their fluidity, and, in specialized tissues, cholesterol is a precursor of bile acids, steroid hormones, and vitamin D.

Cholesterol is synthesized by virtually all tissues in humans, although liver, intestine, adrenal cortex, and reproductive tissues, including ovaries, testes, and placenta, make the largest contributions to the body's cholesterol pool. As with fatty acids, all the carbon atoms in cholesterol are provided by acetate, and NADPH provides the reducing equivalents. The pathway is driven by hydrolysis of the high-energy thioester bond of acetyl CoA and the terminal phosphate bond of ATP. Synthesis occurs in the cytoplasm, with enzymes in both the cytosol and the membrane of the endoplasmic reticulum.

• Cholesterol is synthesized by virtually all tissues in humans, although liver, intestine, adrenal cortex, and reproductive tissues, including ovaries, testes, and placenta, make the largest contributions to the body's cholesterol pool. As with fatty acids, all the carbon atoms in cholesterol are provided by acetate, and NADPH provides the reducing equivalents. The pathway is driven by hydrolysis of the high-energy thioester bond of acetyl CoA and the terminal phosphate bond of ATP. Synthesis occurs in the cytoplasm, with enzymes in both the cytosol and the membrane of the endoplasmic reticulum.