"фан ва технологиялар тарақҚиёти" журналида мақола эълон қилиш талаб ва шартлари

Ключевые слова. Салициловая кислота, синтез, 4-аминобутановая кислота, соль, биологически активное вещество
SALE SYNTHESIS OF SALICYLIC ACID AMIDE WITH AMINOBUTANIC ACID
¹Niyazov L.N., ²Brel A.K., ¹Bahromov H.Q.
¹Bukhara State Medical Institute named after Abu Ali bin Sino,
²Volgograd State Medical University
Annotation. Synthesized salicylic acid chloride and its derivative with 4-aminobutanoic acid. To increase the solubility of substances in water, a dipotassium salt was obtained. The structure of the substances was obtained by NMR-1N-spectroscopy on a Varian Mercury 300 spectrometer and by the capillary method for determining the liquefaction temperature at the melting point SMP-30 (Volgograd State Medical University).
Keywords. Salicylic acid, synthesis, 4-aminobutanoic acid, salt, biologically active substance
Kirish. Bugungi kunda dorivor moddalarni sintez qilish kimyo fanining dolzarb muammolaridan biri hisoblanadi [1]. O‘simliklardan olingan fenolning birikmasi, ya’ni salitsil kislotasi va uning hosilalari umumiy holda salitsilat deb nomlanib, og‘riqni, isitmani va yallig‘lanishni kamaytirish uchun qadimdan ishlatilgan [2-4]. Eramizdan avvalgi uchinchi asrga oid yozuvlarda Gippokrat og‘riq va isitmani yengillashtirish uchun tarkibida salitsilat saqlagan majnuntol po‘sti va barglarini qo‘llagan [5]. Eng yaxshi ma’lum bo‘lgan salitsilat bu – aspirin sifatida tanilgan atsetilsalitsil kislotasi. Yallig‘lanishga qarshi, antipiretik va analgetik ta’siridan tashqari [6-8] aspirinni profilaktik iste’mol qilish yurak xuruji, insult va ayrim saraton kasalligining xavfini kamaytiradi [4, 9, 10].
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Yechiladigan muammo va masalaning qo‘yilishi.
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