Scientific ideas of young scientists

Key words: Osteitis and osteomyelitis, hematogenous osteomyelitis, hyperbaric oxygenation, 
odontogenic osteitis. 
The greatest diagnostic difficulties arise in hematogenous osteomyelitis in the early stages of 
the disease, when the number of diagnostic and treatment-tactical errors exceeds 50%. Posttraumatic 
osteomyelitis is easier to recognize but also difficult to treat. In the last decade, the literature continues 
to discuss questions about the mechanism of laser action in a number of pathological conditions, but 
the effect of laser radiation on inflammatory processes in children with severe complicated HO 
remains not fully understood. The effectiveness of hyperbaric oxygenation (HBO) in the complex 
treatment of osteomyelitis is well known. However, little is known and requires further study such 
property of HBO as modulation of the inflammatory process. 
In recent years, it has been noted that the wide and sometimes irrational use of antibiotics in the 
treatment of acute purulent inflammatory diseases of the Chlo has led to a change in the qualitative 
composition of the microflora. (Biberman Ya.M. et al., 1999; Karnaukhov A.T.) 
A number of authors (Gruzdev N.A., Sovoliev M.M., Roginsky V.V., Karnaukhov, Montanen, 
Kohnlein, Olaitan) are devoted to the study of the features of the occurrence, course and treatment of 
osteitis and osteomyelitis of the facial skeleton in children. In a number of works, the authors propose 
patterns of generalization, the transition of the process to the chronic stage and the prognosis of the 
disease. But despite this, they have not been sufficiently reflected in modern literature and require 
further development. 
Endotoxicosis is one of the main pathogenetic factors in osteomyelitis that determine the 
severity and prognosis of the disease. Probably, the solution to the problem of infectious and 
inflammatory toxicosis is associated with the further development of the concept of endotoxicosis, 
the study of its deeper and more subtle mechanisms. The problem of the relationship between toxic 
and immune reactions is also insufficiently studied. The mechanisms of complications such as 
chronicity, generalization of infection and processes of extensive osteonecrosis remain insufficiently 
studied. They are probably associated with the problem of various disorders of the anti-infectious 
resistance system (AIR) of the body. The available publications on this topic confirm the need for its 
further study and the development of clinical immunology.