Schneiderman Prelims Vol-I. qxd

METABOLIC
Acrodermatitis enteropathica – conjunctivitis, photophobia 
Ped
Derm 19:426–431, 2002; Ped Derm 19:180–182, 2002; AD
116:562–564, 1980; Dermatologica 156:155–166, 1978;
acquired zinc deficiency
Addison’s disease
Angiokeratoma corporis diffusum (Fabry’s disease
(
α
-galactosidase A; deficient lysosomal 
α
N-acetylgalactosaminidase) – X-linked recessive AD
129:460–465, 1993; initially, telangiectatic macules; tortuous
conjunctival vessels 
NEJM 276:1163–1167, 1967
Biotin deficiency 
NEJM 304:820–823, 1981
Biotinidase deficiency – keratoconjunctivitis 
Ped Derm
21:231–235, 2004
Cushing’s disease
Cystic fibrosis
Fucosidosis type III – bulbar conjunctival telangiectasias
Gout – scleritis 
Rook p.3006, 1998, Sixth Edition
Hartnup’s disease
Hyperthyroidism – Graves exophthalmos
Hyperviscosity syndrome
Hypothyroidism
Hypoparathyroidism (keratoconjunctivitis) 
Nephrogenic fibrosing dermopathy 
JAAD 48:42–47, 2003
Porphyria – porphyria cutanea tarda – keratoconjunctivitis;
congenital erythropoietic porphyria – keratoconjunctivitis 
Ped
Derm 20:498–501, 2003; Semin Liver Dis 2:154–63, 1982;
erythropoietic protoporphyria; variegate porphyria
Postmenopausal flushing
Prolidase deficiency – keratitis
Renal failure
Riboflavin deficiency – conjunctivitis and periorificial dermatitis
(seborrheic dermatitis-like) 
Ped Derm 16:95–102, 1999
Scurvy – conjunctival hemorrhage
JAAD 41:895–906, 1999;
NEJM 314:892–902, 1986
Vitamin A deficiency with xerophthalmia
Clinics in Derm
17:457–461, 1999; NEJM 331:551, 1994
Vitamin B
2
deficiency (riboflavin deficiency) – conjunctivitis and
periorificial dermatitis (seborrheic dermatitis-like) 
Ped Derm
16:95–102, 1999; Clinics in Derm 17:457–461, 1999
Vitamin B
6
deficiency – conjunctivitis 
Clinics in Derm
17:457–461, 1999
Vitamin B
12
deficiency 
JAAD 15:1263–1274, 1986
Wilson’s disease
NEOPLASTIC
Bowen’s disease
Epibulbar complex choristoma with nevus sebaceus 
Eyelid and
Conjunctival Tumors, Shields JA and Shields CL, Lippincott
Williams and Wilkins p.211, 1999
Iris nevi in atypical mole syndrome
AD 129:198–201, 1993
Kaposi’s sarcoma 
JAAD 28:371–395, 1993; AD 125:357–361,
1989; JAMA 275:1545, 1996
Leukemia – congenital leukemia cutis 
AD 129:1301–1306,
1993; chronic lymphocytic leukemia
Lipoma
Lymphoma – HTLV I/II leukemia/lymphoma – conjunctivitis
JAAD 38:502, 1998; cutaneous T-cell lymphoma – keratitis,
uveitis 
Arch Ophthalmol 99:272–274, 1981
Melanoma – ciliary body melanoma 
AD 139:1067–1073, 2003
Metastatic carcinoma to the iris
Orbital tumors
Plasmacytoma – retrobulbar 
NEJM 345:1917, 2001
Polycythemia vera
Sebaceous gland carcinoma – may present as
blepharoconjunctivitis
JAAD 33:1–15, 1995; Eyelid and
Conjunctival Tumors, Shields JA and Shields CL, Lippincott
Williams and Wilkins p.43, 1999 
PARANEOPLASTIC
Necrobiotic xanthogranuloma with paraproteinemia – episcleritis
Can J Ophthalmol 32:396–399, 1997; conjunctivitis, keratitis,
uveitis, iritis 
AD 128:94–100, 1992
Paraneoplastic pemphigus – conjunctivitis 
AD 141:1285–1293,
2005; Cutis 61:94–96, 1998; Dermatol Clin 10:557–571, 1992;
NEJM 323:1729–1735, 1990