Phenylthiourea – hypopigmentation of skin and hair
Rook
p.2965, 1998, Sixth
Edition
Physostigmine
Ghatan p.8, 2002, Second Edition
Quinacrine – loss of hair pigmentation
Ghatan p.230, 2002,
Second Edition
Thiotepa eyedrops – periorbital depigmentation
AD 115:973–974, 1979
Triparanol –
hypopigmented hair
Ghatan p.69, 2002, Second
Edition
Valproic acid – hypopigmented hair
Ghatan p.70, 2002,
Second Edition
Vasoconstrictors – nicotine, ergot
Vasopressors – intra-arterial injections of vasopressors
EXOGENOUS AGENTS
Chemical leukoderma
Rook p.1807, 1998, Sixth Edition
Arsenic
Chloroquine/hydroxychloroquine
Hydroquinone
BJD 105 (Suppl.21):51–56, 1981
Monobenzyl ether of hydroquinone
BJD 105
(Suppl.21):51–56, 1981
Monomethyl ether of hydroquinone
BJD 105
(Suppl.21):51–56, 1981
para-tertiary
butyl phenol
BJD 105 (Suppl.21):51–56, 1981;
Dermatologica 135:54–59, 1967
para-tertiary amyl phenol
BJD 105 (Suppl.21):51–56, 1981
para-tertiary butyl catechol
BJD 105 (Suppl.21):51–56, 1981
Lymphocyte infusion – vitiligo
BJD 145:1015–1017, 2001
PUVA therapy for cutaneous T-cell lymphoma – vitiligo-like
leukoderma
BJD 145:1008–1014, 2001
Rubber depigmentation – wristwatch band; biking suit
Swim goggles – periorbital leukoderma (raccoon-like)
Contact
Dermatitis 10:129–131, 1984
Vitamin E – white hair at injection sites of infants
Dermatologica
145:56–59, 1972
INFECTIONS AND INFESTATIONS
Candidiasis – of skin; of nails
in congenital candidiasis
Textbook
of Neonatal Dermatology, p.513, 2001
Dengue fever – exanthem with islands of sparing (‘white islands
in a sea of red’)
Clin Inf Dis 36:1004–1005,1074–1075, 2003;
Tyring p.477, 2002
Gram-negative web space infection – white maceration
Herpes zoster – post-inflammatory depigmentation
Rook
p.2964, 1998,
Sixth Edition; Int J Derm 25:624–628, 1986
Leishmaniasis – post-kala-azar dermal leishmaniasis
Leprosy – indeterminate – hypopigmented macules of face,
arms, buttocks,
or trunk
Rook p.1222, 1998, Sixth Edition;
borderline tuberculoid, tuberculoid – hypopigmented macule
with dry, hairless anesthetic surface with fine wrinkling
Int J Lepr
Other Mycobact Dis 67:388–391, 1999; lepromatous leprosy
Rook p.1224, 1998, Sixth Edition; borderline lepromatous Rook
p.1227, 1998, Sixth Edition; white lunulae Ghatan p.80, 2002,
Second Edition
Measles – Koplik’s spots
Onchocerciasis – hypopigmented and depigmented atrophic
macules of pretibial, inguinal areas, and bony prominences
(leopard skin)
Cutis 65:293–297, 2000; Rook p.1382, 1998,
Sixth Edition
Onychomycosis – superficial white onychomycosis –
Trichophyton rubrum, T. mentagrophytes, Aspergillus species,
Acremonium species (A. strictum), Fusarium solanae,
Onychocola canadensis AD 140:696–701, 2004; JAAD
36:29–32, 1997
Oral hairy leukoplakia
Parvovirus B19 – Koplik’s spots
Pinta – late
secondary phase hypopigmented, depigmented
hyperpigmented atrophic skin
Rook p.1274, 1998, Sixth Edition
AD 135:685–688, 1999; tertiary (late phase) – achromia over
elbows, knees, ankles, wrists back of hands
Rook p.1274, 1998,
Sixth Edition
Pitted keratolysis
Sepsis –
transverse white nail bands
Ghatan p.81, 2002,
Second Edition
Syphilis – secondary; as macular syphilid fades get
depigmented macules with hyperpigmented background
(leukoderma syphiliticum) on back and sides of neck (necklace
of Venus)
Rook p.1248–1249, 1998, Sixth Edition
Tinea pedis
Tinea versicolor
Semin Dermatol 4:173–184, 1985
Verruca – involuting flat wart with halo
Ghatan p.251, 2002,
Second Edition
Yaws – primary red papule, ulcerates, crusted; satellite papules;
become round ulcers, papillomatous or vegetative friable
nodules which bleed easily (raspberry-like) (framboesia); heals
with large atrophic scar with white center with dark halo
Rook
p.1268–1271, 1998, Sixth Edition
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