Schneiderman Prelims Vol-I. qxd

ACROMEGALIC FEATURES
Acquired generalized lipodystrophy – acromegalic features
Rook p.2429, 1998, Sixth Edition
Acromegaloid phenotype with cutis verticis gyrata of scalp and
corneal leukoma (opaque cornea) (Rosenthal–Kloepfer
syndrome) – autosomal dominant; hyperplasia and folding of
facial skin 
Arch Ophthalmol 68:722–726, 1962
Acromegaly – prognathism, frontal bossing, widely spaced
teeth, protruding thick lower lip, edematous thick eyelids, large
triangular ears, large pores, oily hyperhidrotic skin, elongated
blunt thickened fingers, large, furrowed tongue,
hyperpigmentation 
Rook p.2704, 1998, Sixth Edition
Bronchial carcinoid 
Neurosurg 50:1356–1359, 2002; Asian
Cardiovasc Thorac Ann 10:273–274, 2002
Congenital total lipodystrophy (Berardinelli syndrome,
Seip syndrome) – extreme muscularity and generalized loss
of body fat from birth, acanthosis nigricans,
acromegalic features, umbilical hernia, hyperinsulinemia
(fasting and postprandial), early onset diabetes mellitus or
glucose intolerance, hypertriglyceridemia/low HDL-C level,
hirsutism, clitoromegaly 
J Clin Endocrinol Metab
85:1776–1782, 2000
Congenital macrogingivae – profuse hypertrichosis of lower
face, trunk, and extremities with acromegalic features 
Plast
Reconstr Surg 27:608–612, 1962
Hughes’ syndrome – acromegaloid features and thickened oral
mucosa 
J Med Genet 22:119–125, 1985
Lichen myxedematosus
Minoxidil – pseudoacromegaly 
JAAD 48:962–965, 2003
Multiple endocrine neoplasia syndrome
Pachydermoperiostosis – no macroglossia or prognathism;
fingers clubbed
Primary
Secondary
Phenytoin – fetal phenytoin syndrome; coarse facial features,
enlarged lips and nose 
JAAD 18:721–741, 1988
Pseudoacromegaly – autosomal recessive; skin ulcers,
arthro-osteolysis, keratitis, oligodontia 
Am J Med Genet
15:205–210, 1983
Pyoderma chronica glutealis complicated by acromegalic
gigantism 
J Dermatol 25:242–245, 1998
Sanfilippo’s syndrome
Short stature with pleonosteosis and periarticular fibrosis (Leri’s
syndrome) – autosomal dominant; short stature and Mongoloid
facies, thick palms and soles with accentuated creases, flexion
contractures of digits, broad thumbs, genu recurvatum 
J Bone
Joint Surg Am 41:397–408, 1959
Soto’s syndrome(cerebral gigantism) – acromegalic features,
increased height and weight, large hands and feet, mental
retardation 
Dev Med Child Neurol 11:796–797, 1969
Tumors – pancreatic cell, small-cell lung cancer, adrenal adenomas,
pheochromocytomas producing ectopic growth hormone releasing
hormone 
Ann Oncol 12 Suppl 2: 589–594, 2001