Lichen planus
Rook p.1904–1912, 1998, Sixth Edition
Lichen simplex chronicus – knuckle pads
Lichen striatus
Lichen sclerosus et atrophicus – wrists, palms, soles
AD 115:884, 1979
Migratory angioedema – plantar nodule
Ped Derm
15:97–102, 1998
Mosaic acral keratosis
Clin Exp Dermatol 15:361–362, 1990
Necrolytic acral erythema – serpiginous, verrucous
plaques of dorsal aspects of hands, legs; associated with
hepatitis C infection
JAAD 50:S121–124, 2004
Painful piezogenic pedal papules
Caputo p.177, 2000; JAAD
36:780–781, 1997
Palmoplantar keratoderma, epidermolytic (Vorner’s) – papules
on knuckles
BJD 125:496, 1991
Pityriasis lichenoides chronica (guttate parapsoriasis)
Pityriasis rosea
Pityriasis rubra pilaris
Psoriasis
Reactive perforating collagenosis of childhood – digital papule
PSYCHOCUTANEOUS DISEASES
Bulimia nervosa – Russell’s sign (crusted knuckle nodules)
Clin Orthop 343:107–109, 1997; JAAD 12:725–726, 1985;
perniosis
Clin Sci 61:559–567, 1981; pseudo knuckle pads
(calluses on 2nd and 5th MCP joints)
Psychol Med 9;429–48,
1979
SYNDROMES
Acral pseudolymphomatous angiokeratoma in
children (APACHE) – unilateral multiple persistent
vascular papules on hands and feet (cutaneous
pseudolymphoma)
JAAD 48:S15–17, 2003; BJD
145:512–514, 2001; JAAD 38:143–175, 1998; BJD
124:387–388, 1991; red papules JAAD S209–211, 2001;
acral pseudolymphomatous angiokeratoma
Am J
Dermatopathol 16:130–133, 1994
Bart–Pumphrey syndrome – knuckle pads, leukonychia,
deafness and palmoplantar hyperkeratosis
CHILD syndrome – fingertip nodules (verruciform xanthomas)
JAAD 50:S31–33, 2004
Cowden’s syndrome – acrokeratosis verruciformis-like lesions
AD 106:682–690, 1972; Ann Intern Med 48:136–142, 1963;
translucent papules on palms and soles
JAAD 11:1127–1141,
1984; AD 114:743–746, 1978
Dermo–chondro–corneal dystrophy
Ehlers–Danlos syndrome (molluscum pseudotumor) –
knuckle pads
Ellis van Creveld syndrome – polydactyly
JAAD 46:161–183,
2002; Ped Derm 18:68–70, 2001
Epidermodysplasia verruciformis
Familial multiple acral mucinous fibrokeratomas – verrucous
papules of the fingers
JAAD 38:999–1001, 1998
Familial histiocytic dermatoarthritis – knuckle pads
Farber’s disease (disseminated lipogranulomatosis) –
red papules and nodules of joints and tendons of hands
and feet; deforming arthritis; papules, plaques, and
nodules of ears, back of scalp and trunk
Rook p.2642,
1998, Sixth Edition; Am J Dis Child 84:449–500,
1952
Fibroblastic rheumatism – symmetrical polyarthritis,
nodules over joints and on palms, elbows, knees, ears,
neck, Raynaud’s phenomenon, sclerodactyly; skin lesions
resolve spontaneously
AD 139:657–662, 2003; Ped Derm
19:532–535, 2002; AD 131:710–712, 1995; Clin Exp Dermatol
19:268–270, 1994; JAAD 14:1086–1088, 1986; Rev Rheum
Ed Fr 47:345–351, 1980; periungual papules Ped Derm
19:532–535, 2002
François syndrome (dermochondrocorneal dystrophy) – knuckle
pads; nodules on hands, nose, and ears
Ann DV 104:475–478,
1977; AD 124:424–428, 1988
Goltz’s syndrome (focal dermal hypoplasia) – asymmetric
linear and reticulated streaks of atrophy and telangiectasia;
yellow-red nodules; raspberry-like papillomas of lips,
perineum, acrally at perineum, buccal mucosa; xerosis;
scalp and pubic hair sparse and brittle; short stature;
asymmetric face; syndactyly, polydactyly; ocular, dental and
skeletal abnormalities with osteopathia striata of long bones
JAAD 25:879–881, 1991
Hereditary acrokeratotic poikiloderma of Weary –
vesiculopustules of hands and feet at age 1–3 months which
resolve; widespread dermatitis similar to atopic dermatitis;
diffuse poikiloderma with striate and reticulate atrophy; keratotic
papules of hands and feet, elbows and knees; autosomal
dominant
AD 103:409–422, 1971
Hereditary hemorrhagic telangiectasia (Osler–Weber–Rendu
disease)
Rook p.2091, 1998, Sixth Edition; Am J Med
82:989–997, 1987
Hereditary progressive mucinous histiocytosis – autosomal
dominant; skin-colored or red–brown papules; nose, hands,
forearms, thighs
JAAD 35:298–303, 1996; AD 130:1300–1304,
1994
Hidrotic ectodermal dysplasia (Clouston’s syndrome) –
syringofibroadenomas – flat-topped coalescing papules
(acral)
JAAD 40:259–262, 1999
Hunter’s syndrome – MPS II – knuckle pads
Ped Derm
12:370–372, 1995
Incontinentia pigmenti (IP)
JAAD 52:727–729, 2005; – painful
subungual keratotic tumor of IP
JAAD 50:S45–52, 2004; JAAD
47:169–187, 2002; J Hand Surg 18B:667–669, 1993; AD
124:29–30, 1988; JAAD 13:913–918, 1985; AD 94:632–635,
1966
Infantile digital fibromatosis
JAAD 49:974–975, 2003
Infantile systemic hyalinosis – knuckle pads
Ped Derm
11:52–60, 1994
Juvenile hyaline fibromatosis – pearly white papules of face and
neck; larger papules and nodules around nose, behind ears, on
fingertips, knuckle pads; multiple subcutaneous nodules of
scalp, trunk, and extremities, papillomatous perianal papules;
joint contractures, skeletal lesions, gingival hyperplasia, stunted
growth
Textbook of Neonatal Dermatology, p.444–445, 2001;
Caputo p.54, 2000; AD 121:1062–1063, 1985;
AD 107:574–579, 1973
Kindler’s syndrome – acral keratoses
Knuckle pads, leukonychia, and deafness syndrome
Ghatan
p.159, 2002, Second Edition
Knuckle pads with palmoplantar keratoderma and
acrokeratoelastoidosis
Ledderhose’s nodules (plantar fibromatosis)
JAAD 41:106–108,
1999; Dupuytren’s contracture (palmar fibromatosis) and/or
Peyronie’s disease – knuckle pads
Lipoid proteinosis – acral papules
BJD 151:413–423, 2004; JID
120:345–350, 2003; BJD 148:180–182, 2003; Hum Molec Genet
11:833–840, 2002; digital papule AD 132:1239–1244, 1996
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