Particulars containing ETO-NPs with different concentrations.
Sample Particulars
Cytotoxicity
(%)
Cell
viability
(%)
Cytotoxic
Reactivity
Description
Conc.
(µg)
ME1
5
85
15
Severe
10
87
13
Severe
50
83
17
Severe
75
84
16
Severe
100
85
15
Severe
Table 4(b):
The percentage of Cytotoxicity and Cell viability of sample
Particulars with different concentrations.
Sample Particulars
Cytotoxicity
(%)
Cell
viability
(%)
Cytotoxic
Reactivity
Description
Conc.
(µg)
DPEA
5
87
13
Severe
10
88
12
Severe
50
88
12
Severe
75
85
15
Severe
100
85
15
Severe
PPS
5
86
14
Severe
10
89
11
Severe
50
83
17
Severe
75
84
16
Severe
100
83
17
Severe
Results in (Table 4a) show that the synthesized ETO NP
provides higher cytotoxicity and lesser cell viability. These results
are almost agreed with the Cytotoxicity of DPEA and PPA
against the MDA-MB-231 cell line which was shown in (Table
4b). The maximum best result has been observed by adding the 10
µg of synthesized ETO-NPs which killed the 87% of living
MDA-MB-231 breast cancer cells. The overall result shows that
the synthesized ETO-NP kills a minimum of 83% of MDA-MB-
231 breast cancer cells.
Conclusion
ETO-NPs with 60 to 66 nm have been successfully synthesized
and characterized by XRD, UV–Visible, IR, PL spectrum, further
the higher percentage of cytotoxicity against MDA-MB 231 and
antimicrobial activity against micro bacteria and fungus has been
investigated. Using UV-Vis spectrum, it was found that 4f orbital
electrons cause ETO-NPs to absorb visible regions of light from
380 to 700 nm and this photoluminescence property allows ETO-
NPs for designing the photoluminescence devices. XRD spectrum
and TEM topography image with different magnifications
confirmed the existence of ETO-NPs in the synthesized sample
around the size range from 60 to 66 nm. This lesser size property
of ETO-NP displayed a very good toxic activity against Bacillus
SP, E.Coli, Aspergillus, and Mucor. Further, the antibacterial
result concluded that the ETO-NP plays an effective (higher toxic
activity) role against BACILLUS SP and Aspergillus than Mucor
and E. coli Microbial pathogens. The synthesized ETO-NPs
confirmed 87 % of cytotoxicity against the MDA-MB 231 cell
line.
References
1.
Khan I, Saeed K, Khan I. Nanoparticles: Properties, applications
and toxicities. Arabian J Chemistry. 2017.
2.
Jeevanandam J, Barhoum A, Chan YS, Dufresne A, Danquah MK.
Review on nanoparticles and nanostructured materials: history,
sources, toxicity and regulations. Beilstein J Nanotechnology. 2018;
9: 1050-1074.
3.
Barimah KE, Rahayu S, Ziarko MW, Bamiedakis N, White IH,
Penty RV, et al. J Erbium-doped nanoparticle–polymer composite
thin films for photonic applications: structural and optical
properties. ACS Omega. 2020; 16: 9224-9232.
4.
Kaliyamoorthi K, Pillai SA, Alexander A, Ramasamy S, Arivarasu
A, Enoch IVMV. Designed poly (ethylene glycol) conjugate-
erbium-doped magnetic nanoparticle hybrid carrier: enhanced
activity of anticancer drug. J Materials Sci. 2020; 56: 3925-3934.
5.
Baral S, Johnson SC, Alaulamie AA, Richardson HH.
Nanothermometry
using
optically
trapped
erbium
oxide
nanoparticle. Applied Physics A. 2016; 122.
6.
Hazra C, Skripka A, Ribeiro SJL, Vetrone F. Erbium Single‐Band
Nanothermometry in the third biological imaging window: Potential
and limitations. Advanced Optical Materials. 2020.
7.
Zhang X, He S, Ding B, Qu C, Zhang Q, Chen H, et al. Cancer Cell
Membrane-Coated Rare Earth Doped Nanoparticles for Tumor
Surgery Navigation in NIR-II Imaging Window. Chemical
Engineering J. 2019; 385.
8.
Wang K, Wu Y, Li H, Li M, Zhang D, Feng H, et al . Dual-
functionalization based on combination of quercetin compound and
rare earth nanoparticle. J Rare Earths. 2013; 31: 709-714.
9.
Balusamy B, Kandhasamy YG, Senthamizhan A, Chandrasekaran
G, Subramanian MS, Kumaravel TS. Characterization and bacterial
toxicity of lanthanum oxide bulk and nanoparticles. J Rare Earths.
2012; 30: 1298-1302.
10.
Kumar PM, Josephine SGA, Tamilarasan G, Sivasamy A, Sridevi J.
Rare
earth
doped
semiconductor
nanomaterials
and
its
photocatalytic and antimicrobial activities. J Environmental
Chemical Engineering. 2018; 6: 3907-3917.
11.
Lu VM, Donald MKL, Townley HE. Realizing the therapeutic
potential of rare earth elements in designing nanoparticles to target
and treat glioblastoma. Nanomedicine. 2017; 12.
12.
Giri S, Karakoti A, Graham RP, Maguire JL, Reilly CM. Nanoceria:
Do'stlaringiz bilan baham: |