Tchm compounds Synthesis



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Table S5. The typical semi-synthesized or synthesized cytotoxic analogues of the five effective TCHM compounds


TCHM compounds

Synthesis

Typical semi-synthesized or synthesized analogues with anti-tumor effects

Ref.

Polyphyllin I

Y

α-L-rhamnosyl-(12)-β-D-glucoside

[80, 81]

Tanshinone IIA

Y

Acetyl-tanshinone IIA

[82]

Isochaihulactone

NR

Dibenzyl-γ-butyrolactones

[83]

25-OCH3-PPD

NR

Methoxy benzoyl-25-OCH3-PPD

[84]

Andrographolide

Y

Tripropionyl derivative of andrographolide

[85]

Y: yes; NR: not reported;
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