Tchm compounds Synthesis

Table S5. The typical semi-synthesized or synthesized cytotoxic analogues of the five effective TCHM compounds

TCHM compounds	Synthesis	Typical semi-synthesized or synthesized analogues with anti-tumor effects	Ref.
Polyphyllin I	Y	α-L-rhamnosyl-(12)-β-D-glucoside	[80, 81]
Tanshinone IIA	Y	Acetyl-tanshinone IIA	[82]
Isochaihulactone	NR	Dibenzyl-γ-butyrolactones	[83]
25-OCH3-PPD	NR	Methoxy benzoyl-25-OCH3-PPD	[84]
Andrographolide	Y	Tripropionyl derivative of andrographolide	[85]

Y: yes; NR: not reported;
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