Tchm compounds Synthesis

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Table S5. The typical semi-synthesized or synthesized cytotoxic analogues of the five effective TCHM compounds

TCHM compounds


Typical semi-synthesized or synthesized analogues with anti-tumor effects


Polyphyllin I



[80, 81]

Tanshinone IIA


Acetyl-tanshinone IIA








Methoxy benzoyl-25-OCH3-PPD




Tripropionyl derivative of andrographolide


Y: yes; NR: not reported;
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59 Sun X, Chen J, Wang D, Li X. Radix Actinidiae extract inhibits the proliferation of human lung

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83 Alizadeh BH, Foroumadi A, Emami S, Khoobi M, Panah F, Ardestani SK, et al. Isochaihulactone analogues: synthesis and anti-proliferative activity of novel dibenzylbutyrolactones. Eur J Med Chem 2010; 45:5979-5984.

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85 Nanduri S, Nyavanandi VK, Thunuguntla SS, Kasu S, Pallerla MK, Ram PS, et al. Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents. Bioorg Med Chem Lett 2004; 14:4711-4717.

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