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ОИНВ21ВЕКЕ. Март 2022. Том 1

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And there are three main forms of the course in the classification of hemolytic disease. Not only the picture of his symptoms but also the prognosis of the child’s survival / recovery depends on them.
Tumor shape. Fortunately, the least common condition occurs even during pregnancy. Ninety-nine percent of children who suffer from it die before or shortly after birth because it is almost impossible to provide oxygen to the tissues independently because their condition at birth is so severe. . The newborn has a large tumor, the liver is sharply enlarged, reflexes are almost absent, there is heart failure (except for respiratory failure). Early dates of onset of hemolytic disease Pregnancy often ends with abortion.
Ikteric form. It is more extensive than others and manifests itself in the day after birth, where the “incest” only occurs during childbirth. It is also very difficult and can end in death, but in many cases this scenario can be avoided. Jaundice and anemia can last for several more months in a child.
form of anemia. It also occurs in the first days or 2-3 weeks after birth. In general, a newborn baby behaves almost like a healthy baby. Only slight lethargy, paleness, enlarged liver with spleen, and decreased appetite may be observed. Timely treatment can shorten the entire period of anemia hemolytic disease to one month.
Symptoms
Hemolytic disease of the newborn occurs in one of three forms:

  • icteric - in 88% of cases;

  • anemia - 10%;

  • swollen - 2%.

  • Symptoms of icteric form:

  • jaundice - a change in the color of the skin and mucous membranes as a result of accumulation of bilirubin pigment;

  • decrease in hemoglobin (anemia);


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  • enlargement of the spleen and liver (hepatosplenomegaly);


  • lethargy, decreased reflexes, and muscle tone.

In the case of Rh conflict, jaundice appears immediately after birth, according to the AB0 system - 2-3 days. Skin color gradually changes from orange to light lemon.
If the indirect bilirubin level in the blood exceeds 300 ^mol / l, nuclear hemolytic jaundice in newborns may develop in 3-4 days, which is accompanied by damage to the subcortical nuclei of the brain. Nuclear jaundice is characterized by four stages:
Intoxication. It is characterized by loss of appetite, monotonous crying, motor weakness, vomiting.
Nuclear damage. Symptoms are tension in the occipital muscles, sharp crying, swelling of the fontanelle, tremor, (standing with the bow in the back), loss of some reflexes.
Imaginary well-being (improving clinical appearance).
Complications of hemolytic disease of the newborn. Appears at the end of 1 month of life - early 5 months. These include paralysis, paresis, deafness, cerebral palsy, developmental delay, and more.
Symptoms of cholestasis may appear on days 7-8 of hemolytic jaundice in newborns:

  • discoloration of feces;

  • green-dirty skin color;

  • dark urine;

  • an increase in the level of bilirubin in the blood directly.

Clinical manifestations with a form of anemia Hemolytic disease of the newborn includes:

  • anemia

  • rangparlik;

  • hepatosplenomegaly;



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