The in vitro studies performed in - The in vitro studies performed in
- A test tube.
- Root canals of extracted teeth.
- Prepared dentine blocks infected with a pure culture of one organism at a time.
- The in vivo studies, on the other hand, have focused on the elimination of microorganisms from the root canal system in teeth with primary apical periodontitis.
Explanation to poorer in vivo performance - Explanation to poorer in vivo performance
- Root canal anatomy, in particular, the difficulty in reaching the most apical region of the canal with large volumes of fresh irrigant.
- Chemical milieu in the canal is quite different from a simplified test tube environment
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