Bachelor degree



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1. Daniel Scherman. Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology: Principles, Delivery and Pharmacological and Biomedical Applications of Nucleotide-Based Therapies (Icp Textbooks in Biomolecular Sciences). - Imperial College Press, 2013, 400 p.

2. Bertram Katzung, Susan Masters, Anthony Trevor. Basic and Clinical Pharmacology. - McGraw-Hill Medical, 2011, 1248 p.

3. Robert A. Meyers. Pharmacology. - Wiley-Blackwell, 2008, 1126 p.

James M. Parry, Elizabeth M. Parry. Genetic Toxicology: Principles and Methods (Methods in Molecular Biology). – Humana Press, 2011, 452 p.




Module designation


Modules of Individual educational direction /traectory (IED)

Stem cells biotechnology


Module level, if applicable

Module of Individual Educational Trajectory 4: "Genetics technology"


Code, if applicable

SCB 4510

Subtitle, if applicable

not applicable


Courses, if applicable


Course

Credits

Stem cells biotechnology

3







2 lectures + 1 seminar / week

Semester(s) in which the module is taught

7 semester

Person responsible for the module

PhD, Assoc. Prof. Dzhansugurova L.B.

Lecturer


PhD, Assoc. Prof. Dzhansugurova L.B., PhD, Assoc. Prof. Zhumabayeva B.A.

Language

Kazakh, Russian, English

Relation to curriculum


(State/Social/ Vocational/IET)

IET


Type of teaching, contact Hours


Lecture

Practicum

Seminars

30 hours per semester (2 hours per week)

-

15 hours per semester (1 hour per week)




Workload


Lectures

Guided self-study

Self-study

30 hours per semester (2 hours per week)

20 hours per semester

60 hours per semester (4 hours per week)




Seminars










15 hours per semester (1 hour per week)







Credit points


3 credits= 5 ECTS

Requirements according to

the examination regulations


Knowledge of differentiation mechanisms, marking of stem cells, prospects of application of cellular technologies in various areas of medicine, including an organ transplantation, test of medicines.

Recommended prerequisites



BAB 2416 Basics of Animal Biotechnology

Module objectives/intended

learning outcomes



Knowledge


Skills


Competences

Definition of the concept "stem cell" and its main properties, general characteristic and properties of embryonic stem cells, sources of stem cells for the therapeutic purposes, basic elements of eukaryiotic cellular cycle machinery, etc.


Remember:

potentially effective use of cellular biotechnology for scientific and practical purposes;


Understand:

creation of genetically modified stem cells and their use for study of mechanisms of implementation of genetic information during processes of morphogenesis and cellular differentiation.




Methods of study of transcription activity of separate components of the cellular cycle machinery, reporter proteins.
Apply:

modern methods of animal biotechnology;


Analysis:

mechanisms of differentiation.


Ability to design experiments and conduct research on stem cells biotechnology with the latest techniques.


Evaluate:

prospects of application of cellular technologies in various areas of medicine;


Create:

awareness of the ways for obtaining regenerates and their transformation.



Content


The course will contain the following topics:

Stem cells biotechnology:

1. Concept of a stem cell. Definition of the concept "stem cell" and its main properties. Hypothesis of the mechanism of regulation of self-maintenance of stem cells.

2. Embryonic stem cells. General characteristic and properties of embryonic stem cells. Markers of embryonic stem cells.

3. Approaches to bioengineering designing of cellular lines of embryonic stem cells with the set properties for the medicinal purposes.

4. Ethical issues in study of stem cells. Sources of stem cells for the therapeutic purposes.

5. Ethical dilemma when using human embryonic stem cells. Induced pluripotent stem cells.

6. Basic elements of cellular cycle machinery and their role in regulation of cell division. Phases of a cellular cycle.

7. Role of separate elements of cellular cycle machinery. Basic elements of eukaryiotic cellular cycle machinery.

8. Intracellular and extracellular control of cellular division and growth.

9. Role of family of a product of a gene of a retinoblastoma in control of a cellular cycle, differentiation and apoptosis in somatic and stem cells.

10. Structure and functions of chromatin. Features of chromatin organization in embryonic stem cells.

11. Structural organization of control area of eukaryotic gene. Mechanisms of interaction between proteins of pRb u E2F families.

12. Role of regulation of transcription in operation of the cellular cycle machinery.

13. Methods of study of transcription activity of separate components of the cellular cycle machinery. Methods of reporter proteins.

14. Signal pathways of Bmi1 u Shh in regulation of functions of stem cells.

15. Somatic and tumor stem cells and their classification. Stem cells of skin and application in medicine. Concluding remarks.



Study and examination

requirements and forms of

examination

1st interim control: attendance, in-class discussion, problem solving, testing

2nd interim control: attendance, in-class discussion, problem solving, testing

Final examination: written, 2 theoretical questions, 1 practical question



Media employed

Flash and ppt presentations

Reading list

References (all in English):

1. Joseph Panno. Stem Cell Research: Medical Applications and Ethical Controversies. - Checkmark Books, 2010, 262 p.

2. Robert Lanza et al. Essentials of Stem Cell Biology. Academic Press, 2009, 680 p.


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