Content
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The course will contain the following topics:
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Basics of genetics analysis:
1, 2, 3. Genetic aspects of individual development of living organisms at the site of genetic studies of the fruit fly Drosophila melanogaster.
4, 5, 6, 7. Current understanding of the molecular genetics of control of all phases of development in ontogeny after oocyte maturation and research on the combination of features of the body.
8, 9, 10, 11. Genes that control the development of the Drosophila mutations and their mechanism of action.
12, 13, 14, 15. Genetics of the fruit fly and achievements in the field of experimental embryology and modern molecular biology.
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Study and examination
requirements and forms of
examination
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1st interim control: attendance, in-class discussion, problem solving, testing
2nd interim control: attendance, in-class discussion, problem solving, testing
Final examination: written, 2 theoretical questions, 1 practical question
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Media employed
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Flash and ppt presentations
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Reading list
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References:
Mark F. Sanders, John L. Bowman. Genetic Analysis: An Integrated Approach. - Benjamin Cummings, 2011, 864 p. (in English)
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Module designation
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Modules of Individual educational direction /traectory (IED)
Cytogenetics of Human and Animal |
Module level, if applicable
| Module of Individual Educational Trajectory 4: "Genetics technology" |
Code, if applicable
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CHA 4507
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Subtitle, if applicable
| not applicable |
Courses, if applicable
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Course
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Credits
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Cytogenetics of Human and Animal
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3
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2 lectures + 1 lab / week
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Semester(s) in which the module is taught
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7 semester
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Person responsible for the module
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PhD, Assoc. Prof. Kalimagambetov A.M.
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Lecturer
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PhD, Assoc. Prof. Kalimagambetov A.M.
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Language
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Kazakh, Russian, English
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Relation to curriculum
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(State/Social/ Vocational/IET)
IET
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Type of teaching, contact Hours
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Lecture
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Practicum
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Seminars
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30 hours per semester (2 hours per week)
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15 hours per semester (1 hour per week)
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-
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Workload
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Lectures
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Guided self-study
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Self-study
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30 hours per semester (2 hours per week)
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15 hours per semester (1 hour per week)
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60 hours per semester (4 hours per week)
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Credit points
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3 credits= 5 ECTS
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Requirements according to
the examination regulations
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Knowing basic principles of cytogenetic methods for studying chromosomes, modern advances in the study of structural and functional organization of metaphase chromosomes in normal and pathological conditions.
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Recommended prerequisites
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GMG 2412 General and molecular genetics
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Module objectives/intended
learning outcomes
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Knowledge
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Skills
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Competences
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Basic principles of cytogenetic methods, general morphology of interphase and metaphase chromosomes, levels of chromosome organization, factors, inducing chromosomal aberrations, chromosomal diseases, etc.
Remember:
the mechanisms of chromosome aberrations and crossing-over;
Understand:
the features of structural and functional organization of chromosomes and their reproduction.
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Methods used for prevention and diagnostics of chromosomal diseases.
Apply:
the basic principles of cytogenetic methods for studying chromosomes;
Analysis:
X-chromatin, metaphase cells and the construction of the karyotype.
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Ability to design experiments and conduct research on human and animal cytogenetics.
Evaluate:
data gained in practical research in the field of medical genetics and biotechnology;
Create:
experiment on study of structural and functional organization of metaphase chromosomes in normal and pathological conditions.
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Content
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The course will contain the following topics:
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Cytogenetics of Human and Animal:
1. Basic principles of cytogenetic methods.
2. Modern methods of human cytogenetics.
3. General morphology of interphase and metaphase chromosomes.
4. Reproduction of chromosomes.
5, 6. Molecular structure of metaphase chromosomes.
7. Levels of chromosome organization.
8, 9. Eukhromatin and heterochromatin. Telomerase.
10. Crossing-over.
11. Chromosomal mutations.
12. Factors, inducing chromosomal aberrations.
13. Chromosomal diseases: violations in system of sexual chromosomes.
14. Chromosomal diseases: violations in system of autosomes.
15. Prevention and diagnostics of chromosomal diseases.
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Study and examination
requirements and forms of
examination
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1st interim control: attendance, in-class discussion, problem solving, testing
2nd interim control: attendance, in-class discussion, problem solving, testing
Final examination: written, 2 theoretical questions, 1 practical question
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Media employed
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Flash and ppt presentations
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Reading list
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References:
Rooney D.E. Human Cytogenetics: Malignancy and Acquired Abnormalities. 3-rd edition. – Oxford University Press, 2001, 287 p. (in English)
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Module designation
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Modules of Individual educational direction /traectory (IED)
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