Scientific supervisors: ass.M.B.Kosimova., ass. O.J.Khamidov
Relevance of scientific work:The marigold (Calendulaofficinalis
L.
Asteraceae) and an oak bark
(Cortex Quercus) are widespread in Uzbekistan and applied in traditional medicine at diseases of
system of an oral cavity as antimicrobial, anti-inflammatory and antiallergenic means
Various medicines and tinctures used in cosmetics are isolated from these plants. Besides, these
plants are a part of difficult component medicinal complexes. The marigold and an oak bark have a
complex chemical composition and presented such biological active substances as apiin and rutin
(flavonoids), umbelliferon and gerniarin (coumarins), chamazulene (ether oils), tannins, alkaloids,
triterpenealcohols, choline,phytosterols, ascorbic acid, carotin, enveloping agents.Plants are applied
in medicine in the form of tincture, elixirs and unguent as disinfecting means at such diseases as
stomatitis, a periodontal disease and throat.
The aim of the work: Receiving the form of medicinal containing oak bark extracts with the
extracts of a marigold and chamomiles applicable at inflammation and a cold, treatment of the skin
diseases and introduction of the received results in pharmaceutical.
Methods and materials: The quantity of ether oil was determined by the Ginzburg’s method.
Mathematical processing of experimental results was carried out with requirements of “The book of
Pharmacopeia XI, volume 2”. By the data it was revealed that the content of tannins in dry extracts
of a marigold and an oak bark increased by 10-11% in comparison with a raw material.
In order to isolate of biologically active compounds from plants the water and 96% ethanol was
used as the solvent in the ratio of 1:1. For this, the 10 g of the crushed and passed through a bolter
of cell of 1 mm in size dry plants mixed with 100 ml of solvent, heated on a water bath within 30-45
minutes and left for one day. This process was repeated by 5 times, filtrates united and boiled out on
a water bath to dry solid.As a basis of the gel, the production of the Namangan chemical plant -
water soluble sodiumcarboxymethylcellulose (the degree of substitution is about 70, the degree of
polymerization 450, density 1.59 g/cm3) was used.For the gel formation the 8 g Na-
carboxymethylcellulose, 0.1 g of dry extracts of a marigold and an oak bark, 20 g of glycerin, 0.2 g
of a nipagin dissolved in water carry general volume to 100g. The thick, brown and the
homogeneous gel wasformed.
Do'stlaringiz bilan baham: |