Ўзбекистон миллий университети ҳузуридаги фан доктори илмий даражасини берувчи

O.Ziyаdullaev
Сhairman of the Scientific Council for
awarding of the scientific degrees,
Doctor of Chemical Sciences, Docent
G.Otamuxamedova
Scientific Secretary of the Scientific Council
for awarding the scientific degrees,
Doctor of Philosophy in Chemistry (PhD)
A.Maxsumov
Chairman of the Scientific Seminar
Council for awarding of scientific degrees,
Doctor of Chemical Sciences, Professor
I NTRODUCTION (abstract of PhD thesis)
The aim of research work is a comparative study and development of optimal methods for the synthesis of new mono- and diamides of acids, the synthesis of new compounds based on homoveratrylamine and heterocyclic acids, and determination of their physicochemical and biological properties.
The objects of the research work are N-, O-, S-containing heterocyclic acids, homoveratrylamine, and their amidation products.
The scientific novelty of the study is as follows:
for the first time the reactions of heterocyclic mono- and dibasic carboxylic acids containing cycles of imidazole, benzoxazole, cytisine, dithiolan, pyridine with homoveratrylamine were carried out and factors influencing the course of the process were identified;
the comparison of amidation methods (thermal, microwave and ultrasonic) was carried out and the optimal conditions for the synthesis of the selected heterocyclic acids were revealed;
for the first time the catalytic properties of boric acid, copper (I) chloride, TEOS on the reactions of amidation of heteroacids with homoveratrylamine were studied;
it was found that microwave amidation decreases the reaction time (1-15 minutes), and 20 mol% boric acid is most effective for activating the carboxyl group at room temperature in the presence of ultrasound;
it was found that the sulfur atom is easily exchanged for nitrogen with the formation of hydrazone carboxylic acid during the amidation of 3- (2-thioxobenzo [d] oxazole) propanoic acid;
it was found that the dehydration takes place during thermal amidation of 3- [1- (2-hydroxyethyl)-1H-imidazol-4-yl] propanoic acid;
the dependence of the yields of the reaction products on the position of the carboxyl group was established; the presence of the carboxyl group in the alkyl chain stimulates the formation of the product.