Webster's New World Medical Dictionary

osteocyte
A bone cell.
osteodystrophy
A bone disorder that adversely
affects bone growth and development. Osteo-
dystrophy is most commonly caused by chronic kid-
ney failure, but it can be inherited, such as in
Albright hereditary osteodystrophy. Osteodystrophy
can require treatment with vitamin D. See also
osteodystrophy, renal.
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osteodystrophy
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osteodystrophy, renal
A bone disorder that
adversely affects bone growth and is caused by
chronic kidney failure (renal disease). Osteo-
dystrophy can require treatment with vitamin D.
Also known as kidney osteodystrophy.
osteogenesis
The production of bone.
osteogenesis imperfecta
A group of inherited
connective tissue diseases, all of which result from
mutations that affect collagen in connective tissue in
the body, and all of which result in fragile bones. The
best known types of osteogenesis imperfecta are
types I and II. Also known as brittle bone disease.
osteogenesis imperfecta congenita
See
osteogenesis imperfecta type II.
osteogenesis imperfecta tarda
See 
osteogene-
sis imperfecta type I.
osteogenesis imperfecta type I
A type of osteo-
genesis imperfecta that features bone fragility
and blue sclerae (bluish whites of the eyes).
Osteogenesis imperfecta type I is the classic, mild
form of brittle bone disease. It is inherited as an
autosomal dominant trait. It is characterized by frag-
ile bones that are predisposed to fracture, the onset
after birth of growth deficiency, abnormal teeth that
look as if they have been sandblasted, thin skin, blue
sclerae, and overly extensible joints. Common prob-
lems include the development of bowed legs, curva-
ture of the spine (scoliosis and kyphosis), umbilical
and inguinal hernias, and mild mitral valve prolapse.
Hearing impairment begins in the third decade of
life, due to otosclerosis, a disorder of the bones of
the middle ear. Also known as osteogenesis imper-
fecta tarda and Lobstein disease.