Webster's New World Medical Dictionary

sanguine 1
Having a ruddy (reddish) complex-
ion.
2
Cheerful, hopeful, confident, optimistic, or
impulsive.
saphenous vein
One of the two saphenous
veins—the great and the small saphenous veins—
that serve as the principal veins running near the
surface of the leg. The saphenous veins carry deoxy-
genated blood from the feet and legs toward the
heart. See also 
saphenous vein, great; saphenous
vein, small.
saphenous vein, great
The larger of the two
saphenous veins, which runs from the foot all the
way up to the saphenous opening, an oval aperture
in the broad fascia of the thigh. The great saphenous
vein passes through this fibrous membrane. Also
known as large saphenous vein.
saphenous vein, large
See 
saphenous vein,
great.
saphenous vein, small
The smaller of the two
saphenous veins, which runs behind the outer
malleolus (the protuberance on the outside of the
ankle joint), comes up the back of the leg, and
joins the popliteal vein in the space behind the
knee (popliteal space). See also 
saphenous vein.
SAPHO syndrome
Synovitis, acne, pustulosis,
hyperostosis, and osteitis syndrome, which involves
symptoms including warmth, tenderness, pain,
swelling, and stiffness of involved joints (arthritis);
fluid-filled blister-like areas (pustules), typically on
the palms of the hands and/or the soles of the feet,
and peeling and flaking of skin in those areas; abnor-
mal, excessive growth of bone, frequently at the
points of the bone where tendons attach; and inflam-
mation of the sacroiliac joints (sacroiliitis), as well as
inflammation of the spine (spondylitis), leading to
stiffness and pain of the neck and back. SAPHO syn-
drome is thought to be related to other arthritic con-
ditions that typically affect the spine, including
ankylosing spondylitis and reactive arthritis.