Университети кимё – технология факультети

SULFATE 
a
Kudiyarova A.D., 
b
Ashurov J. M., 
c
Ibragimov A.B., 
d
Mengnorov I.J., 
c
Sabirov V. Kh. 
a
Karakalpak State University named after Berdak, Nukus, Uzbekistan 
b
Institute of Bioorganic Chemistry Academy of Sciences of Uzbekistan 
c
Institute of General and Inorganic Chemistry Academy of Sciences of Uzbekistan, 
d
Tashkent State Technical University Named After Islam Karimov 
A novel Co-complex of the fluoroquinolone antibiotic ciprofloxacin has 
been synthesized and structurally characterized by the single-crystal X-ray 
diffraction method as a compound with the composition of [Co(H
2
O)
6
]
2+
2(SO
4
)
2-
·2HL
+
·6H
2
O (
I
) (where L= ciprofloxacin). The crystal structure of 
I
consists of the 
[Co(H
2
O)
6
]
2+
octahedron and two singly charged (HL)
+
cations, two sulfate anions 
and six H
2
O molecules (Fig. 1.).

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40
Fig. 1. Ortep drawing of the complex I. The ellipsoids of the ADP is shown 
at the level 50%. Dotted lines are designated the hydrogen bonds. 
The Co
2+
-ions lie on the symmetry axis 2 at the position 4e. Two water 
molecules around the Co
2+ 
ion and each of the O atoms of the sulfate group are 
disordered into two positions with occupation factors of 0.60 and 0.40 in the first 
case and 0.46 and 0.54 in the second case. 
Fig. 2. The Hirschfeld surface for (HL)
+
-cation. Dotted lines indicate 
hydrogen bonds and non-bonded weak interactions. 
Hirschfeld surface analysis of the structure are used for visualization all 
types of the intra- or intermolecular interactions in the crystal structure. Points with 
a contribution to the surface are coloured blue for small contributions, through 
green to red for points with the greatest contributions. The red spots on the surface 

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41
show the leading strong interactions (Fig. 2.). The complete Hirschfeld surface 
area analysis of crystal structure shows weak H∙∙∙H contacts contribute 40.5 %, 
O∙∙∙H/O∙∙∙H interaction contributes 34 % to the total inter­actions. Further, the 
percentage contribution of other weak interactions are as follows: C∙∙∙C/C∙∙∙C 6.9 
%, H∙∙∙F/F∙∙∙H 6.4 %, H∙∙∙C/C∙∙∙H 5.4%, C∙∙∙O/O∙∙∙C 3.4%, N∙∙∙C/C∙∙∙N 1.2%, 
O∙∙∙F/F∙∙∙O 0.7%. The Fig.2 displays, that the non-bonded specific interactions 
make a large contribution to the total parameter and it shows that (HL)
+
-cations 
may be linked to supramolecular units by variety of ways.