388 Chapter
12
Development
important in the history of biology (International Human Genome Sequencing
Consortium, 2003).
The success of the Human Genome Project started a revolution in health care
because scientists can identify the particular genes responsible for genetically caused
disorders. It is already leading not only to the identifi cation of risk factors in chil-
dren, but also to the development of new treatments for physical and psychological
disorders.
For example, in
gene therapy, health-care providers inject genes to correct par-
ticular diseases directly into a patient’s bloodstream. When the gene arrives at the
location of a problem (or potential problem), it leads the body to produce chemicals
that can alleviate the danger. In other cases, additional genes are inserted that replace
missing or defective cells. Eventually, it also may be possible to “harvest” defective
cells from a child prior to birth. These cells could be treated by gene therapy and
reintroduced into the unborn child to repair the defect (Lymberis et al., 2004; Sato,
Shimamura, & Takeuchi, 2007; Naldini, 2009).
Although the promise of gene therapy is real, the number of diseases that can
be treated today is fairly limited. Furthermore, the long-term success of gene ther-
apy remains unknown. In fact, after they initially seem to be cured, some recipients
of gene therapy have relapsed, and some have suffered from unpleasant side
effects. Still, the potential uses of gene therapy are growing rapidly. For example,
such disorders as AIDS, cancer, rheumatoid arthritis, and macular degeneration are
strong candidates for the procedure (Feret et al., 2007; Rossi, June, & Kohn, 2007;
Miller et al., 2008).
The Earliest Development
When an egg becomes fertilized by the sperm, the resulting one-celled entity, called
a
zygote, immediately begins to develop. The zygote starts out as a microscopic
speck. Three days after fertilization, though, the zygote increases to around 32 cells;
within a week it has grown to 100–150 cells. These fi rst two weeks are known as the
germinal period .
Two weeks after conception, the developing individual enters the
embryonic
period, which lasts from week 2 through week 8; he or she is now called an
embryo.
As an embryo develops through an intricate, preprogrammed process of cell divi-
sion, it grows 10,000 times larger by 4 weeks of age and attains a length of about
one-fi fth of an inch. At this point it has developed a rudimentary beating heart, a
brain, an intestinal tract, and a number of other organs. Although all these organs
are at a primitive stage of development, they are clearly recognizable. Moreover,
by week 8, the embryo is about an inch long and has discernible arms, legs, and
a face.
From week 8 and continuing until birth, the developing individual enters the
fetal period and is called a
fetus. At the start of this period, it begins to respond to
touch; it bends its fi ngers when touched on the hand. At 16 to 18 weeks, its move-
ments become strong enough for the mother to sense them. At the same time, hair
may begin to grow on its head, and the facial features become similar to those the
child will display at birth. The major organs begin functioning, although the fetus
could not be kept alive outside the mother. In addition, a lifetime’s worth of brain
neurons are produced—although it is unclear whether the brain is capable of think-
ing at this early stage.
By week 24, a fetus has many of the characteristics it will display as a newborn.
In fact, when an infant is born prematurely at this age, it can open and close its eyes;
suck; cry; look up, down, and around; and even grasp objects placed in its hands.
Within the womb the fetus continues to develop before birth. It begins to grow fatty
deposits under the skin, and it gains weight. The fetus reaches the
age of viability, the
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