To enlighten investors on the impact of these breakthroughs and the opportunities they should create, we began publishing Big Ideas in 2017. This annual research report seeks to highlight


Multi-Cancer Screening Could Prevent Roughly



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ARK–Invest BigIdeas 2021

Multi-Cancer Screening Could Prevent Roughly 
66,000 Cancer Deaths Annually In The US
0
10,000
20,000
30,000
40,000
50,000
60,000
70,000
Annu
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 Av
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Earlier Detection Could Lower Cancer Mortality
Narrow Panel, 
Age 50-80 
Broad 
Panel, Age 50-80 
Broad Panel,
Age 40-80 
Motor Vehicle 
Deaths



Multi-Cancer Screening And Other Genomic Technologies 
Are Transforming Oncology
Multi-Cancer Screening
Source: ARK Investment Management LLC, 2020. [1] Hu, Chunling, et al. “The Contribution of Germline Predisposition Gene Mutations to Clinical Subtypes of Invasive Breast Cancer From a Clinical Genetic Testing Cohort.” JNCI: Journal of 
the National Cancer Institute, 2020, doi:10.1093/jnci/djaa023. [2] Lennon, Anne Marie, et al. “Feasibility of Blood Testing Combined with PET-CT to Screen for Cancer and Guide Intervention.” Science, vol. 369, no. 6499, 2020, 
doi:10.1126/science.abb9601. [3] “Our Products.” Our Products, 2020, www.veracyte.com/our-products. [4] “Personalized Cancer Monitoring.” Edited by ArcherDx, Personalized Cancer Monitoring, 14 Aug. 2020, archerdx.com/diagnostic-
products/personalized-cancer-monitoring/. 
104
Hereditary Cancer 
Testing
can influence
the onset and frequency
of cancer screening.
1
Multi-Cancer Screening 
can 
detect cancers in early and 
treatable stages.
2
Single-Cancer Screening 
plays a vital role in detecting 
several forms of cancer.

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