South Boston Scleroderma and Lupus Health Study Massachusetts Department of Public Health Bureau of Environmental Health January 2010

Table 35: Frequency of Residential Exposures

		Cases (%)	Controls (%)	Odds Ratio	95% Confidence Interval
Basement Level Residence	Yes	2 (4.9)	20 (13.0)	0.3	0.1	1.5
	No	39 (95.1)	134 (87.0)
Portable Heater	Yes	8 (19.5)	26 (16.9)	1.2	0.5	2.9
	No	33 (80.5)	128 (83.1)

Table 36: Frequency of Chlorinated Solvent Exposures

			Cases (%)	Controls (%)	Odds Ratio	95 % Confidence Interval
Occupational Exposure^*		Yes	9 (22.0)	46 (29.9)	0.7	0.3	1.5
		No	32 (78.0)	108 (70.1)
	Specific^†	Yes	1 (2.4)	5 (3.2)	0.8	0.1	6.6
		No	40 (97.6)	149 (96.8)
	Possible^‡	Yes	8 (19.5)	41 (26.6)	0.7	0.3	1.6
		No	33 (80.5)	113 (73.4)

^* Category includes both possible and specific exposures.

^† Specific refers to either an occupational or hobby related exposure that was confirmed by the participant (e.g., Yes, I worked in printing/publishing and yes, I used benzene.).

^‡ Possible is defined as having worked in an occupation or participated in a hobby where exposure was possible (e.g., Yes, I worked in printing/publishing but I did not use benzene.).


Table 37: Univariate Analysis of SSc/SLE Risk and Residential Proximity within 30 Feet of Hazardous Waste Sites in South Boston (Residence at Index Date)

	Odds Ratio	95% Confidence Interval
Hazardous Waste Site w/Petroleum Compounds	1.3	0.2	8.5
Hazardous Waste Site w/Compounds Other than Petroleum	---	---	---
Any Hazardous Waste Site	1.3	0.2	8.5

Table 38: Univariate Analysis of SSc/SLE Risk and Residential Proximity within 500 Feet of Hazardous Waste Sites in South Boston (Residence at Index Date)

	Odds Ratio	95% Confidence Interval
Hazardous Waste Site w/Petroleum Compounds	0.4	0.2	1.0
Hazardous Waste Site w/Compounds Other than Petroleum	0.5	0.1	3.1
Any Hazardous Waste Site	0.5	0.2	1.1

Table 39: Univariate Analysis of SSc/SLE Risk and Residential Proximity within 30 Feet of Hazardous Waste Sites in South Boston (Longest South Boston Residence)

	Odds Ratio	95% Confidence Interval
Hazardous Waste Site w/Petroleum Compounds	---	---	---
Hazardous Waste Site w/Compounds Other than Petroleum	---	---	---
Any Hazardous Waste Site	---	---	---

Table 40: Univariate Analysis of SSc/SLE Risk and Residential Proximity within 500 Feet of Hazardous Waste Sites in South Boston (Longest South Boston Residence)

	Odds Ratio	95% Confidence Interval
Hazardous Waste Site w/Petroleum Compounds	0.8	0.5	1.2
Hazardous Waste Site w/Compounds Other than Petroleum	0.4	0.1	2.7
Any Hazardous Waste Site	0.8	0.5	1.2

Table 41: Univariate Analysis of SSc/SLE Risk and Historical Exposure to Emissions from Boston Edison Power Plant Based on Residential History (High versus Low Impact Area)

		Cases	Controls	Odds Ratio	95% Confidence Interval
Residence at Index	High	21	71	1.2	0.4	3.8
	Low	4	16
Longest Residence	High	35	119	1.9	0.7	5.3
	Low	5	31

Table 42: Frequency of Swimming

		Cases (%)	Controls (%)	Odds Ratio	95 % Confidence Interval
Pleasure Bay	Yes	28 (68.3)	103 (66.9)	1.2	0.6	2.7
	No	11 (26.8)	50 (32.5)
	Unknown	2 (4.9)	1 (0.6)
Castle Island	Yes	17 (41.5)	55 (35.7)	1.3	0.7	2.7
	No	23 (56.1)	99 (64.3)
	Unknown	1 (2.4)	0 (0)
L Street Beach	Yes	28 (68.3)	112 (72.7)	1.0	0.4	2.1
	No	11 (26.8)	42 (27.3)
	Unknown	2 (4.9)	0 (0)
Carson Beach	Yes	32 (78.0)	82 (53.2)	3.5	1.5	8.0
	No	8 (19.5)	71 (46.1)
	Unknown	1 (2.4)	1 (0.6)
Reserve Channel	Yes	4 (9.8)	7 (4.5)	2.5	0.7	9.0
	No	32 (78.0)	139 (90.3)
	Unknown	5 (12.2)	8 (5.2)
Pleasure Bay and/or Castle Island	Yes	23 (56.1)	66 (42.9)	1.9	0.9	3.9
	No	16 (39.0)	87 (56.5)
	Unknown	2 (4.9)	1 (0.6)
L Street and/or Carson Beach	Yes	15 (36.6)	51 (33.1)	1.2	0.6	2.5
	No	25 (61.0)	103 (66.9)
	Unknown	1 (2.4)	0 (0)

Table 43: Frequency of Recreational Park Use

		Cases (%)	Controls (%)	Odds Ratio	95 % Confidence Interval
M Street Park	Yes	25 (61.0)	87 (56.5)	1.3	0.6	2.6
	No	15 (36.6)	65 (42.2)
	Unknown	1 (2.4)	2 (1.3)
Marine Park	Yes	18 (43.9)	78 (50.6)	0.8	0.4	1.6
	No	21 (51.2)	74 (48.1)
	Unknown	2 (4.9)	2 (1.3)
Columbia Park	Yes	26 (63.4)	87 (56.5)	1.4	0.7	2.9
	No	14 (34.1)	65 (42.2)
	Unknown	1 (2.4)	2 (1.3)

Table 44: Unmatched Multivariate Regression Analysis of Risk of SSc/SLE and Possible Risk Factors (Complete Model)

Regression Model Covariates	Odds Ratio	95% Confidence Interval
Family History of Autoimmune Disease	1.9	0.9	4.1
Previous Diagnosis of Rheumatoid Arthritis	3.4	1.3	9.3
Use of medication for Psychotic Disorder	2.0	0.8	5.2
Possible Hobby-related Silica Exposure	2.3	1.1	4.4

Table 45: Unmatched Multivariate Regression Analysis of Risk of SSc/SLE and Possible Risk Factors (Final Model)

Regression Model Covariates	Odds Ratio	95% Confidence Interval
Previous Diagnosis of Rheumatoid Arthritis	4.4	1.7	11.5
Possible Hobby-related Silica Exposure	2.4	1.1	5.0

Table 46: Matched Multivariate Regression Analysis of Risk of SSc/SLE and Possible Risk Factors (Complete Model)

Regression Model Covariates	Odds Ratio	95% Confidence Interval
Family History of Autoimmune Disease	2.0	0.9	4.5
Previous Diagnosis of Rheumatoid Arthritis	3.5	1.3	9.8
Use of medication for Psychotic Disorder	1.9	0.7	5.0
Possible Hobby-related Silica Exposure	2.5	1.1	5.6

Table 47: Matched Multivariate Regression Analysis of Risk of SSc/SLE and Possible Risk Factors (Final Model)

Regression Model Covariates	Odds Ratio	95% Confidence Interval
Previous Diagnosis of Rheumatoid Arthritis	4.0	1.5	11.0
Possible Hobby-related Silica Exposure	2.6	1.2	5.7

Table 48: Matched Multivariate Regression Analysis of Risk of SSc/SLE and Residential Proximity to Hazardous Waste Sites Based on Longest South Boston Residence

Regression Model Covariates	Odds Ratio	95% Confidence Interval
Family History of Autoimmune Disease	1.8	0.9	3.9
Previous Diagnosis of Rheumatoid Arthritis	4.2	1.5	11.9
Hazardous Waste Site w/Petroleum Compounds (30 Feet)	< 0.1	---	---
Hazardous Waste Site w/Petroleum Compounds (500 Feet)	0.7	0.4	1.2

Table 49: Matched Multivariate Regression Analysis of Risk of SSc/SLE and Historical Exposure to Emissions from Boston Edison Power Plant Based on Longest South Boston Residence

Regression Model Covariates	Odds Ratio	95% Confidence Interval
Family History of Autoimmune Disease	2.0	0.9	4.2
Previous Diagnosis of Rheumatoid Arthritis	4.4	1.6	12.2
Longest Residence in High versus Low Impact Area	2.3	0.8	6.6