Pachydermoperiostosis
JAAD 38:359–362, 1998
Spade-like enlargement of hands and feet
Warmth of fingertips, paronychia
Excessive sweating of hands and feet
Coarsening facial features mimicking acromegaly
Leonine facies, worried or angry look
Cutis verticis gyrata
Palmar plantar keratoderma
Greasiness to skin
Clubbing
+
periostitis
+
acromegalic features
Asymptomatic periosteal reaction
Mild arthralgia
Severe deep-seated
aching or burning pain, aggravated by
dependency
Tenderness over distal long bones
Insidious onset, mild rheumatic complaints
Idiopathic, suppurative pulmonary disease
Rapidly progressive, prominent joint pain
Malignant disease
PAPA syndrome – pyoderma gangrenosum, cystic acne,
aseptic arthritis; sterile abscesses at injection sites; mutation
in CD2 binding protein-1
Ped Derm 22:262–265, 2005; Proc
Natl Acad Sci USA 100:13501–13506, 2003; Mayo Clin Proc
72:611–615, 1997
Papular–purpuric
gloves and socks syndrome
Ped Derm
15:413, 1998
Periodic fever
BJD 151:99–104, 2004
POEMS syndrome – bilateral Charcot joints
Dtsch Med
Wochenschr 124:346–350, 1999
Progeria (Hutchinson–Guilford syndrome)
AD
125:540–544, 1989
Proteus syndrome – skeletal overgrowth of arms and legs
limiting joint mobility
AD 140:947–953, 2004
Pseudoacromegaly – autosomal recessive; skin ulcers,
arthro-osteolysis, keratitis, oligodontia
Am J Med Genet
15:205–210, 1983
Reflex sympathetic dystrophy – limited joint mobility
Cutis 68:179–182, 2001
Reiter’s syndrome
Circinate balanitis
Asymptomatic oral mucosal erosions
Keratoderma blenorrhagica
Pustular
psoriasis
Psoriasiform plaques
Nail changes
Geographic tongue
Seronegative non-suppurative arthritis – polyarticular
knees, ankles, metatarsophalangeal, sacroiliac joints;
relative sparing of hands and wrists; occasionally
monoarticular
Rook p.2764, 1998
Spondylitis
Achilles tendonitis
Plantar fasciitis
Sausage digits – dactylitis
Relapsing polychondritis – may mimic rheumatoid arthritis
Clin Rheumatol 6:453–457, 1987; Medicine 55:193–216,
1976
REM syndrome (reticular erythematous mucinosis syndrome)
Acta DV 66:442–445, 1986
Rosai–Dorfman syndrome
Am J Clin Pathol 82:515–525, 1984
SAPHO syndrome – palmoplantar pustulosis with
sternoclavicular hyperostosis; acne fulminans, acne
conglobata, hidradenitis suppurativa,
psoriasis, multifocal
osteitis
Cutis 71:63–67, 2003; Cutis 64:253–258, 1999; Cutis
62:75–76, 1998; Rev Rheum Mal Osteoarthritic 54:187–196,
1987; Clin Rheumatol 5:118–123, 1986; Ann Rev Rheum Dis
40:547–553, 1981
Schnitzler’s syndrome – monoclonal IgM kappa light
chain macroglobulinemia, intermittent fever, bone pain,
lymphadenopathy, hyperostosis, peripheral neuropathy
J Eur Acad Dermatol Venereol 16:267–270, 2002
Schopf–Schulze–Passarges syndrome
Self-healing juvenile mucinosis
Ped Derm 14:460–462, 1997
SHORT syndrome – short stature, hyperextensible joints,
ocular
depression, Reiger (ocular and dental) anomaly,
teething delay, loss of subcutaneous fat of face, upper
extremities, chest and Sjögren’s syndrome
Rook p.2572, 1998,
Sixth Edition
Soto’s syndrome – joint hyperextensibility; cutis laxa; cerebral
gigantism
J Med Genet 36:51–56, 1999
Stiff skin syndrome – joint contractures
Ped Derm 20:339–341,
2003; Ped Derm 19:67–72, 2002
Sweet’s syndrome
JAAD 23:494–498, 1990; Arthritis Rheum
18:35–41, 1975; BJD 76:349–356, 1964; including drug-induced
Sweet’s syndrome – red plaques, nasal ulcers, perianal ulcers –
celecoxib, G-CSF, all-trans retinoic acid
JAAD 45:300–302, 2001
Trichorhinophalangeal syndrome I – autosomal dominant; pear-
shaped nose, tubercle of normal skin below the lower lip,
fusiform
swelling of the PIP joints; fine brittle sparse hair,
eyebrows sparse laterally, dense medially, short stature
JAAD
31:331–336, 1994
Tuberous sclerosis – pseudocysts of the phalanges
Rook
p.2739, 1998, Sixth Edition
Tumor necrosis factor (TNF) receptor 1-associated periodic
fever syndromes (TRAPS) (same as familial Hibernian fever,
autosomal dominant periodic fever with amyloidosis, and benign
autosomal dominant familial periodic fever) – erythematous
patches, tender red plaques, fever, annular, serpiginous,
polycyclic, reticulated, and migratory
patches and plaques
(migrating from proximal to distal), urticaria-like lesions, lesions
resolving with ecchymoses, conjunctivitis, periorbital edema,
myalgia, arthralgia, abdominal pain, headache; Irish and
Scottish predominance; mutation in TNFRSF1A – gene
encoding 55kDa TNF receptor
AD 136:1487–1494, 2000
Tricho-rhino-phalangeal syndrome
J Ped Orthop 6:133–138,
1986
Weill–Marchesani syndrome
Wells’ syndrome
JAAD 52:187–189, 2005; Trans St. Johns Hosp
Dermatol Soc 57:46–56, 1971
Werner’s syndrome
Rook p.2739, 1998, Sixth Edition
Winchester syndrome – systemic hyalinosis with joint
contractures
JAAD 50:S53–56, 2004
Dwarfism, osteolysis, corneal opacities
Osteoporosis
Rheumatoid-like joint destruction
Hyperpigmentation
Hypertrichosis
Thickening of the skin
Widespread nodular lesions
Am J Med Genet
26:123–131, 1987J Pediatr 84:701–709, 1974;
Pediatrics 47:360–369, 1971
TOXINS
Eosinophilia myalgia syndrome (
L
-tryptophan related) –
arthralgia
Int J Dermatol 31:223–228, 1992; Mayo Clin Proc
66:457–463, 1991; Ann Intern Med 112:758–762, 1990
Hypervitaminosis A – bone pain
Arch Intern Med
112:462–466, 1963
Polychlorinated biphenyl poisoning – chloracne, goiter,
arthritis,
and anemia
Environ Health Perspect 107:715–719, 1999
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