Schneiderman Prelims Vol-I. qxd

ARTHRITIS AND RASH
57
Schneiderman page 1-100.qxd 5/16/2006 6:49 PM Page 57

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Infiltrated scar
Scars of abdomen, neck, TB skin test sites
In tattooed areas with onset of systemic sarcoid 
Cutis
36:423, 1985
Hypopigmentation 
AD 108:249, 1973
Scaling
Erythroderma
Psoriasiform 
AD 106:896, 1972
Ichthyosiform
Cicatricial alopecia 
AD 107:758, 1973
Ulcerative sarcoid
Tender punched-out ulcers
Ulcers within generalized papules or nodules
Mucosal involvement
Angiolupoid sarcoid of Brocq and Pautrier
Erythema nodosum, Lofgren’s syndrome
Heerfordt’s syndrome – uveoparotid fever 
JAAD 13:314, 1985
Juvenile sarcoid 
JAAD 48:S99–102, 2003
Scleromyxedema 
JAAD 43:403–408, 2000
Ulcerative colitis, regional enteritis
METABOLIC DISEASES
Angiokeratoma corporis diffusum (Fabry’s disease (alpha
galactosidase A) – X-linked recessive; arthritis of terminal
phalanges
JAAD 17:883–887, 1987; NEJM 276:1163–1167,
1967
Complement deficiency – deficiency of beta subunit of the
eighth component of complement – arthritis and exanthem
Arthritis Fheum 37:1704–1706, 1994
Cryoglobulinemia 
JAAD 48:311–340, 2003
Diabetes – neuropathy – Charcot joint; diabetic cheiropathy
(stiff joints and waxy skin) 
NEJM 305:191–194, 1981
Gout 
Cutis 48:445–451, 1991; Ann Rheum Dis
29:461–468, 1970
Hemochromatosis – arthropathy 
JAAD 51:205–211, 2004; Hum
Molec Genet 9:2377–2382, 2000; Schweiz Med Wochenschr
122:842–849, 1992; AD 113:161–165, 1977; Medicine
34:381–430, 1955
Homocystinuria – joint dysplasia
Hyperlipidemia
Type II hyperlipoproteinemia
Tendinous xanthomas or nodules
Achilles tendon, patella tendon, extensor tendons of
hands and feet
Migratory polyarthritis that affects large joints
Acute episodes of Achilles tendonitis
Mixed cryoglobulinemia
Nephrogenic fibrosing dermopathy (scleromyxedema-like
cutaneous fibrosing disorder) – stiff joints and flexion
contractures; associated with chronic renal failure with or
without hemodialysis 
JAAD 48:55–60, 2003; JAAD 48:42–47,
2003; Am J Med 114:563–572, 2003; AD 139:903–906, 2003;
Am J Dermatopathol 23:383–393, 2001; Lancet
356:1000–1001, 2000
Ochronosis (alkaptonuria) – autosomal recessive; homogentisic
acid dioxygenase deficiency 
JAAD 52:122–124, 2005; NEJM
347:2111–2121, 2002; Rook p.2649, 1998, Sixth Edition; Am J
Med 34:813–838, 1963
Diaper discoloration with alkaline soap
Brown–black cerumen, apocrine, eccrine sweat
Gray–blue discoloration of thin skin overlying pigmented
cartilage, tendon; nose tip, extensor tendons, ears
Scleral discoloration
Onset of arthritis in 40s
Males
>
females
Shoulders, knees, hips
Spine
Calcified intervertebral discs
Lumbar pain, kyphosis, lordosis, sciatica
Oxaluria – primary hyperoxaluria 
JAAD 49:725–728, 2003;
livedo and arthritis) 
AD 125:551–556, 1989; AD 116:213–214,
1980
Pancreatic panniculitis – periarticular subcutaneous nodules
JAAD 45:325–361, 2001; Rook p.2414, 1998, Sixth Edition;
JAAD 34:362–364, 1996; J Rheumatol 19:630–632, 1992;
Arthritis Rheum 22:547–553, 1979
Subcutaneous erythematous nodules
Often tender
Legs – posterior, lateral not tibial
Buttocks, trunk
Occasionally fluctuant
Spontaneous breakdown, drain creamy sterile material
Arthritis, periarthritis
Ankles, feet
Fat necrosis
Periarticular
Synovial membrane
Marrow cavity
Scurvy – hemarthrosis or subperiosteal hemorrhage 
JAAD
41:895–906, 1999; NEJM 314:892–902, 1986
Sickle cell anemia – dactylitis with unequal growth of digits
Rook p.2736, 1998, Sixth Edition
Sitosterolemia – arthritis and tuberous xanthomas 
J Lipid
Research 33:945–955, 1992
Vitamin A intoxication – bone aches in children 
Rook p.2656,
1998, Sixth Edition
Waldenström’s hypergammaglobulinemic purpura