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A CLINICIAN’S GUIDE TO DERMATOLOGIC DIFFERENTIAL DIAGNOSIS, VOLUME 1



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[Encyclopedia of Differential Diagnosis in Dermatology] Paul Schneiderman, Marc E. Grossman - A Clinician\'s Guide to Dermatologic Differential Diagnosis, Volume 1 The Text (Encyclopedia of Differential Diagnosis in D

576
A CLINICIAN’S GUIDE TO DERMATOLOGIC DIFFERENTIAL DIAGNOSIS, VOLUME 1
Schneiderman page 500-600.qxd 5/16/2006 6:51 PM Page 576


Squamous cell carcinoma – intraoral red patch 
Rook p.3057,
1998, Sixth Edition; Oral Oncol 31B:16–26, 1995; diffuse
epidermal and periadnexal squamous cell carcinoma in
situ – diffuse erythema and hyperkeratosis of face, neck, and
scalp 
JAAD 53:623–627, 2005
PARANEOPLASTIC DISORDERS
Generalized eruptive histiocytosis associated with acute
myelogenous leukemia 
JAAD 49:S233–236, 2003
Glucagonoma syndrome – erythema mimicking cellulitis 
JAAD
49:325–328, 2003
PRIMARY CUTANEOUS DISEASES
Circumscribed palmar or plantar hypokeratosis – red atrophic
patch 
JAAD 51:319–321, 2004; JAAD 49:1197–1198, 2003;
JAAD 47:21–27, 2002
Granuloma annulare – patch-type granuloma annulare 
JAAD
51:39–44, 2004; JAAD 46:426–429, 2002; Rook p.2301, 1998,
Sixth Edition
Intertrigo
Lichen planus – intraoral red patch 
Rook p.3057, 1998,
Sixth Edition
Progressive symmetric erythrokeratoderma (Gottron syndrome)
Ped Derm 19:285–292, 2002; AD 136:665, 668, 2000;
AD 122:434–440, 1986
Red scrotum syndrome 
Genital Skin Disorders, Fischer and
Margesson, Mosby p.53, 1998
Scleredema of Buschke (pseudoscleroderma) – in diabetics,
preceded by erythema 
Clin Exp Dermatol 14:385–386, 1989
SYNDROMES
Acute anterior tibial compartment syndrome – cellulitis-like
JAAD 34:521–522, 1996
Amyoplasia congenita disruptive sequence – mid-facial macular
telangiectatic nevi 
Am J Med Genet 15:571–590, 1983
Angiokeratoma corporis diffusum
Bannayan–Riley–Ruvalcaba–Zonana syndrome (PTEN
phosphatase and tensin homolog hamartoma) – dolicocephaly,
frontal bossing, macrocephaly, ocular hypertelorism, long
philtrum, thin upper lip, broad mouth, relative micrognathia,
lipomas, penile or vulvar lentigines, facial verruca-like or
acanthosis nigricans-like papules, multiple acrochordons,
angiokeratomas, transverse palmar crease, accessory nipple,
syndactyly, brachydactyly, vascular malformations,
arteriovenous malformations, lymphangiokeratoma, goiter,
hamartomatous intestinal polyposis 
JAAD 53:639–643, 2005
Beckwith–Wiedemann syndrome (exomphalos–macroglossia–
gigantism) (EMG) syndrome – autosomal dominant; zosteriform
rash at birth, exomphalos, macrosomia, macroglossia,
visceromegaly, facial salmon patch of forehead, upper eyelids,
nose, and upper lip and gigantism; linear earlobe grooves,
circular depressions of helices; increased risk of Wilms’ tumor,
adrenal carcinoma, hepatoblastoma, and rhabdomyosarcoma;
neonatal hypoglycemia 
Curr Prob Dermatol 13:249–300, 2002;
Am J Med Genet 79:268–273, 1998; JAAD 37:523–549, 1997;
Am J Dis Child 122:515–519, 1971
Bowel-associated dermatitis–arthritis syndrome – red annular or
oval macules, red papules, vesicles evolving into pustules
AD 138:973–978, 2002
Cardiofaciocutaneous syndrome – port wine stain, hypotonia,
mental retardation, atrial septal defect, pulmonary stenosis,
dermatitis, hypotrichosis, characteristic facies 
Clin Genet
42:206–209, 1992
Carcinoid syndrome – persistent erythema with or without
telangiectasia 
Rook p.2717, 1998, Sixth Edition
C syndrome (Opitz trigonocephaly syndrome) – nevus
flammeus; trigonocephaly, unusual facies with wide alveolar
ridges, multiple frenula, limb defects, visceral anomalies,
redundant skin, mental retardation, hypotonia 
Am J Med
Genet 9:147–163, 1981
Coats’ disease – cutaneous telangiectasia or unilateral macular
telangiectatic nevus with retinal telangiectasia 
AD 108:413–415,
1973
Cobb’s syndrome (cutaneomeningospinal angiomatosis) –
segmental port wine stain and vascular malformation of the
spinal cord 
AD 113:1587–1590, 1977; NEJM 281:1440–1444,
1969; Ann Surg 62:641–649, 1915; PWS may be keratotic
Dermatologica 163:417–425, 1981
Familial dysautonomia (Riley–Day syndrome) (hereditary
sensory and autonomic neuropathy type III) – blotchy erythema
in infancy with 2–5-cm red macules on trunk and extremities
AD 89:190–195, 1964
Familial Hibernian fever – mimicking infectious cellulitis 
Ann
Intern Med 142:47–55, 2005; QJMed 51:469–480, 1982
Familial Mediterranean fever – mimicking infectious cellulitis
Ann Intern Med 142:47–55, 2005; NEJM 350:904–912, 2004;
Isr Med Assoc J 1:31–36, 1999; Q J Med 75:607–616, 1990
Fegeler syndrome – acquired port wine stain following trauma
Ped Derm 21:131–133, 2004
Goodpasture’s syndrome – annular erythematous macules on
instep – 
AD 121:1442–4, 1985
Hemihyperplasia–multiple lipomatosis syndrome – extensive
congenital vascular stain, compressible blue nodule, multiple
subcutaneous nodules, hemihypertrophy, syndactyly, thickened
but not cerebriform soles, dermatomyofibroma 
Soc Ped Derm
Annual Meeting, July 2005; Am J Med Genet 130A:111–122,
2004; Am J Med Genet 79:311–318, 1998
Hereditary hemorrhagic telangiectasia – arteriovenous
malformation 
BJD 145:641–645, 2001
Hereditary mucoepithelial dysplasia (dyskeratosis) – red eyes,
non-scarring alopecia, keratosis pilaris, erythema of oral
(palate, gingiva) and nasal mucous membranes, cervix, vagina,
and urethra; increased risk of infections, fibrocystic lung disease
BJD 153:310–318, 2005; JAAD 21:351–357, 1989; Am J Hum
Genet 31:414–427, 1979; Oral Surg Oral Med Oral Pathol
46:645–657, 1978
Hereditary neurocutaneous angioma – autosomal dominant;
port wine stains with localized CNS vascular malformations
J Med Genet 16:443–447, 1979
Hypereosinophilic syndrome – necrotizing eosinophilic vasculitis
BJD 143:641–644, 2000
Hyper-IgD syndrome – autosomal recessive; red macules or
papules, urticaria, red nodules, urticaria, combinations of
periodic fever, arthritis, arthralgias, and rash, annular erythema,
and pustules, abdominal pain with vomiting and diarrhea,
lymphadenopathy; elevated IgD and IgA – mevalonate kinase
deficiency 
Ped Derm 22:138–141, 2005; AD 136:1487–1494,
2000; AD 130:59–65, 1994; Medicine 73:133–144, 1994; Lancet
1:1084–1090, 1984
Kawasaki’s disease – mimicking periorbital cellulitis 
NEJM
350:904–912, 2004; oral erythema Oral Surg 67:569–572,
1989; perianal erythema and desquamation
AD 124:1805–1810, 1988
Klinefelter variants – macular telangiectatic vascular nevi
J Urol 119:103–106, 1978

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