Schneiderman Prelims Vol-I. qxd

258
A CLINICIAN’S GUIDE TO DERMATOLOGIC DIFFERENTIAL DIAGNOSIS, VOLUME 1
Schneiderman page 200-300.qxd 5/16/2006 6:49 PM Page 258

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Cyclophosphamide – black longitudinal or transverse bands
of the nails, brown lines on the teeth, or widespread
hyperpigmentation or limited to palms and soles
JAAD 39:524–525, 1998
Cyclosporine – hair darkening; hyperpigmentation of nails,
palms and soles, teeth 
Bolognia p.978, 2003; Int J Derm
38:229–230, 1999
Daunorubicin 
Rook p.3383, 1998, Sixth Edition
Desipramine 
J Clin Psychopharmacol 13:76–77, 1993
Diltiazem – reticulated, blue–gray, photodistributed
hyperpigmentation in black patients 
Cutis 73:239–240, 2004;
JAAD 46:468–469, 2004; AD 137:179–182, 2001
Doxorubicin – gray to black horizontal nail bands,
hyperpigmentation of palmar creases, buccal mucosa, and face
JAAD 39:524–525, 1998
Doxycyline – brown nails 
Ghatan p.78, 2002, Second Edition
Etretinate – darkening of hair 
JAAD 34:860, 1996
Fixed drug eruptions 
Rook p.1785–1786, 1998, Sixth Edition
5-fluoruracil – supravenous hyperpigmentation 
JAAD
39:524–525, 1998
Gold (chrysiasis) – slate-blue hyperpigmentation around the
eyes and in sun-exposed areas 
JAAD 39:524–525, 1998; oral
gold with laser therapy 
AD 131:1411–1414, 1995
Heavy metals
Hydantoin – melasma-like 
Dermatologica 129:121–139, 1964
Hydroxychloroquine
Hydroxyurea – nail pigmentation (brown nail discoloration)
AD 135:818–820, 1999; longitudinal and/or diffuse
JAAD 47:146–147, 2002; hyperpigmentation over pressure
areas and back 
Bolognia p.978, 2003; AD 111:183–187, 1975
Imipramine – slate-gray hyperpigmentation in sun-exposed
areas 
JAAD 39:524–525, 1998
Interferon and ribavirin therapy 
BJD 149:390–394, 2003
Intramuscular iron injections
Iron – intramuscular iron injections
Isoniazid
Ketoconazole – brown nails 
Ghatan p.78, 2002, Second Edition
Latanaprost (prostaglandin F
2
analog) eyedrops – eyelash
darkening 
Arch Ophthalmol 115:1206–1208, 1997
Mechlorethamine, topical 
Rook p.3383, 1998, Sixth Edition
Melphalan – brown nails 
Ghatan p.78, 2002, Second Edition
Methotrexate 
Rook p.3383, 1998, Sixth Edition
Minocycline – gray or blue–gray hyperpigmentation in areas of
previous inflammation, on mucous membranes, and pretibial
areas 
JAAD 44:342–347, 2001; JAAD 39:524–525, 1998; brown
nails 
Ghatan p.78, 2002, Second Edition
Mithramycin – prominent erythema of face followed by
hyperpigmentaion 
JAAD 39:524–525, 1998
Mitomycin 
Rook p.3383, 1998, Sixth Edition
Nitrogen mustard – brown nails 
Ghatan p.78, 2002,
Second Edition
p-amino benzoic acid – darkening of hair Rook p.3395, 1998,
Sixth Edition
Pefloxacin – blue–black pigmentation of legs 
AD 131:856–857,
1995
Phenothiazines – blue–gray or brown photopigmentation 
Rook
p.3383, 1998, Sixth Edition
Psoralen – brown nails 
Ghatan p.78, 2002, Second Edition
PUVA – darkening of hair 
BJD 146:325–329, 2002
Quinine – hyperpigmentation of arms
Cutis 75:114–116, 2005
Radiation recall – erythema, vesiculation, erosions,
hyperpigmentation; dactinomycin and doxorubicin 
Mayo Clin
Proc 55:711–715, 1980; edatrexate, melphalan, etoposide,
vinblastine, bleomycin, fluorouracil, hydroxyurea, methotrexate
Rook p.3469, 1998, Sixth Edition
Stem cell factor – subcutaneous injections of human
recombinant stem cell factors 
Cutis 71:149–152, 2003; JAAD
33:577–583, 1995
Sulfasalazine – reversible hyperpigmentation 
Am J
Gastroenterol 87:1654–1657, 1992
Sulfonamides – brown nails 
Ghatan p.78, 2002, Second Edition
Sulfones
Tamoxifen – darkening of hair 
BJD 132:483–484, 1995
Tetracycline – teeth 
Rook p.3051, 1998, Sixth Edition; brown
nails 
Ghatan p.78, 2002, Second Edition
Thiotepa 
Rook p.3383, 1998, Sixth Edition; pigmentation under
bandages 
AD 125:524–527, 1989
Verapamil – darkening of hair 
Lancet 338:1520, 1991
Zidovudine 
JAAD 46:284–293, 2002