Python Programming for Biology: Bioinformatics and Beyond



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[Tim J. Stevens, Wayne Boucher] Python Programming

biology):

Protein sequence



(molecular biology):

Pseudorandom number



(computing):

Purifying selection



(biology):

Quantile function



(mathematics):

Quantile normalisation



(statistics):

Ramachandran plot



(bioinformatics):

Random variable



(mathematics):

Rank (mathematics):

polypeptide chains. Proteins are the diverse, functional

molecules of living organisms that catalyse and control

biological processes.

The order in which the different kinds of amino acid residues

are joined together, to create the polypeptide chain of a protein.

A value generated by an algorithm to mimic the effect of having

random numbers. Pseudorandom numbers are not truly random

(they may eventually repeat, for example) but often appear to be

sufficiently random to perform various computational tasks,

such as the Monte Carlo method.

Also referred to as negative selection, the tendency for the

evolutionary process, in some situations, to select gene

sequences that do not change, i.e. to remove sequence variation.

A function that determines the confidence interval around the

sample mean, given a specified confidence level.

A technique for mapping the statistical properties of one sample

distribution to another distribution. This is achieved by

replacing values for data points in one distribution with

equivalent values from the other distribution that share the same

rank (preserving order of relative magnitude).

A two-dimensional plot of the backbone (phi and psi) dihedral

angles in a polypeptide, showing how the chain twists and

indicating common conformations like alpha-helices and beta-

strands.


A mathematical construct to describe random behaviour, usually

for some specified model of the randomness. A way of

assigning a label to a property that has its value selected at

random, according to a given probability distribution.

With reference to matrices, the maximum number of linearly

independent rows or columns.




Raster (graphics):

Raw string (computing):

Read (molecular

biology):

Readable (computing):

Reading frame



(biochemistry):

Real (mathematics):

Reflections

(crystallography):

Regular expression



(computing):

Relational database



(computing):

Relative entropy



(mathematics):

To compose an image from a regular array of pixels, i.e. as a

pixmap, in contrast to using vector graphics where images are

described in terms of geometric shapes.

A Python string where the standard Python escape characters

(i.e. prefixed with ‘\’) are not active and instead the string is

considered literally as typed.

In the context of sequencing, the experimental determination of

one, often small, section of DNA sequence; which may then be

combined with others.

Whether the data stored in a file, e.g. on disk, can be accessed.

When referring to the translation of an RNA sequence, or its

DNA equivalent, to a protein amino acid sequence.

A number from the unrestricted continuum of negative and

positive values, i.e. not a complex number.

A pattern of regularly spaced spots created when X-ray radiation

diffracts through a crystal (an atomic lattice). The spots are

points of constructive interference between the X-rays.

The specification of a particular pattern of characters that may

be sought within a text string. The pattern itself is a string,

which can contain both literal characters and metacharacters,

with the latter describing ambiguous character groups, and thus

the type of pattern to be searched for.

A way of storing certain types of structured data that allows fast

querying of logical relationships in the data.

A measure of whether two variable quantities have the same

distribution, and equivalently a measure of the information

content one distribution holds above another. This is related to

Shannon information entropy, where the comparison is instead

with respect to a random distribution. The relative entropy is

useful because it indicates that data is significant and different.



Replica exchange Monte

Carlo (computing):

Replicas (computing):

Residue (biochemistry):

Resolution


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