NEOPLASTIC DISEASES
Aortic tumors, primary
Oncology 39:167–172, 1982
Atrial myxoma
Cutis 62:275–280, 1998; JAAD 32:881–883,
1995; JAAD 21:1080–1084, 1989
Fibroma with pressure and occlusion
Ghatan p.99, 2002,
Second Edition
Lymphoma – CTCL with ischemic foot
JAAD 47:914–918, 2002;
angiocentric lymphoma – Raynaud’s phenomenon
BJD
142:1013–1016, 2000
Myeloma
Ghatan p.97, 2002, Second Edition
Myeloproliferative diseases – chronic myelogenous leukemia
with leukostasis; acrocyanosis as a sign
Bolognia, p.1947,
2003; AD 123:921–924, 1987
Pheochromocytoma
Polycythemia vera
Rook p.2714, 1998, Sixth Edition
Thrombocythemia – livedo reticularis, acrocyanosis,
erythromelalgia, gangrene, pyoderma gangrenosum
Br J Haematol 36:553–564, 1977; AD 87:302–305, 1963
Tumor emboli – melanoma
AD 129:1205–1207, 1993; aortic
angiosarcoma with cutaneous metastases
JAAD 43:930–933,
2000
Waldenström’s macroglobulinemia – cryoglobulin-associated
acrocyanosis, Raynaud’s phenomenon
JAAD 45:S202–206,
2001
PARANEOPLASTIC DISEASES
Digital ischemia
Br Med J iii:208–212, 1967
Paraneoplastic acral vascular syndrome – acral cyanosis and
gangrene
JAAD 47:47–52, 2002; AD 138:1296–1298, 2002
Robboy’s acral cyanosis – associated with gastric
adenocarcinoma
Rev Esp Enferm Apar Dig 74:562–564, 1988
PRIMARY CUTANEOUS DISEASES
Erythromelalgia
AD 139:1337–1343, 2003; JAAD 43:841–847,
2000; AD 136:330–336, 2000
Nodular erythrocyanosis
Rook p.2204, 1998, Sixth Edition
Palmoplantar keratoderma
Acta DV 75:331, 1995
Symmetrical lividity of the soles (hyperhidrosis)
PSYCHOCUTANEOUS DISEASES
Anorexia nervosa
Postgrad Med J 67:33–35, 1991
SYNDROMES
Acrocyanosis – hands, feet, nose, ears, lips, nipples
JAAD
S207–208, 2001; Rook p.962, 1998, Sixth Edition
Acrocyanosis of infancy
JAAD S207–208, 2001
Angiokeratoma corporis diffusum – (Fabry’s disease)
(
α
-galactosidase A deficiency) – X-linked recessive; acral
areas cyanotic or blanched due to autonomic dysfunction
NEJM 276:1163–1167, 1967
Antiphospholipid antibody syndrome
– Raynaud’s phenomenon,
acral cyanosis
NEJM 346:752–763, 2002; Semin Arthritis
Rheum 31:127–132, 2001; JAAD 36:149–168, 1997; JAAD
36:970–982, 1997; BJD 120:419–429, 1989
Bazex syndrome – bulbous/violaceous fingertips; club-like
Carcinoid syndrome – cyanotic nose and face, rosacea
Acta DV
(Stockh) 41:264–276, 1961
Carpal tunnel syndrome
AD 120:517–519, 1984
Cockayne’s syndrome
Coffin–Lowry syndrome – loose easily stretched skin and
acrocyanosis
Compartment syndrome – crush injury of thorax
AD 138:1296–1298, 2002
DaCosta’s syndrome
Acta DV 18:265–283, 1937
Down’s syndrome – short stature, cutis marmorata,
acrocyanosis, low-set, small ears
JAAD 46:161–183, 2002;
Rook p.3015–3016, 1998, Sixth Edition
Dyskeratosis congenita
Fibroblastic rheumatism – symmetrical polyarthritis; nodules
over joints and on palms, elbows, knees, ears, neck;
Raynaud’s phenomenon; sclerodactyly; skin lesions resolve
spontaneously
Ped Derm 19:532–535, 2002; AD
131:710–712, 1995
Hereditary acrolabial telangiectasia – telangiectasias, blue lips,
nipples, hands, feet, elbows, knees
AD 115:474–478, 1979
Hereditary hemorrhagic telangiectasia (Osler–Weber–Rendu
disease) – pulmonary arteriovenous fistulae
Rook p.2091,
1998, Sixth Edition; Am J Med 82:989–997, 1987
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