Schneiderman Prelims Vol-I. qxd

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A CLINICIAN’S GUIDE TO DERMATOLOGIC DIFFERENTIAL DIAGNOSIS, VOLUME 1
Schneiderman page 600-722.qxd 5/16/2006 6:51 PM Page 704

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Vogt–Koyanagi–Harada syndrome – occurs primarily in Asians,
blacks, and darkly pigmented Causians; Stage 1 – aseptic
meningitis; Stage 2 – uveitis (iritis, iridocyclitis) and dysacusis
(tinnitus, hearing loss); Stage 3 – depigmentation of skin (60% of
patients), depigmentation of hair (poliosis – eyelashes, eyebrows,
scalp, and body hair – 90% of patients), alopecia areata; halo
nevi 
Ann DV 127:282–284, 2000; AD 88:146–149, 1980
von Willebrand’s disease with albinism 
Rook p.2737, 1998,
Sixth Edition
Waardenberg’s syndrome – type I – white forelock; dystopia
canthorum, broad nasal root, synophrys, iris heterochromia,
deafness, canities, piebaldism; hypoplasia of nasal alae, terminal
hair on tip of nose; PAX 3 gene mutation; type II – sensorineural
hearing loss, heterochromic irides, absence of dystopia
canthorum; MITF mutations; type III (Waardenbug–Klein
syndrome) – features of type I, limb abnormalities; PAX 3 gene
mutations; type IV (Waardenburg–Shah syndrome) – extensive
depigmentation; Hirschsprung’s disease; endothelin receptor B
gene mutations 
Textbook of Neonatal Dermatology, p.361, 2001;
Dermatol Clin 6:205–216, 1988
Werner’s syndrome (pangeria) – graying of temples in teenage
years 
Medicine 45:177–221, 1966
Woolf syndrome – autosomal recessive; piebaldism with
congenital nerve deafness 
JAAD 48:466–468, 2003; Arch
Otolaryngol 82:244–250, 1965
Xeroderma pigmentosum – acute sunburn, persistent erythema,
freckling – initially discrete, then fuse to irregular patches of
hyperpigmentation, dryness on sun-exposed areas; with time
telangiectasias and small angiomas, atrophic white macules
develop; vesiculobullous lesions, superficial ulcers lead to
scarring, ectropion; multiple malignancies; photophobia,
conjunctivitis, symblepharon, neurologic abnormalities 
Adv
Genet 43:71–102, 2001; Hum Mutat 14:9–22, 1999; Mol Med
Today 5:86–94, 1999; Derm Surg 23:447–455, 1997; Dermatol
Clin 13:169–209, 1995; Recent Results Cancer Res
128:275–297, 1993; AD 123:241–250, 1987; Ann Intern Med
80:221–248, 1974; XP variant AD 128:1233–1237, 1992
Ziprkowski–Margolis syndrome – X-linked recessive,
deaf-mutism, heterochromic irides, piebald-like hypomelanosis
JAAD 48:466–468, 2003
TOXINS
Arsenic – Mee’s lines of nails 
BJD 149:757–762, 2003
Perchlorethylene-induced Raynaud’s phenomenon
Thallium – transverse white nail bands 
Ghatan p.81, 2002,
Second Edition
Vinyl chloride exposure
TRAUMA
Burns
Cryotherapy 
Rook p.3249,3574, 1998, Sixth Edition
Delayed deep pressure urticaria
Friction blisters
Frostbite – waxy white appearance 
Rook p.958, 1998,
Sixth Edition
Heavy metal intoxication – Mees’ lines; transverse striated
leukonychia 
Textbook of Neonatal Dermatology, p.512, 2001
Physical trauma – hypopigmented hair 
Ghatan p.70, 2002,
Second Edition
Radiation therapy – hypopigmented hair 
Rook p.2964, 1998,
Sixth Edition
Scars
Sun damage – pseudoscars
Tropical immersion foot
Vibration white finger 
Int Arch Occup Environ Health
73:150–155, 2000; Rook p.931, 1998, Sixth Edition