N., and Bakry, N. M. (2006)

Loura, Luis M. S., Fedorov, Aleksandre, and Prieto, Manuel (2000). Partition of membrane probes in a gel/fluid two-component lipid system: a fluorescence resonance energy transfer study. Biochimica et Biophysica Acta (BBA) - Biomembranes 1467: 101-112.
Chem Codes: Chemical of Concern: DZ Rejection Code: METHODS.

A non-ideal lipid binary mixture (dilauroylphosphatidylcholine/ distearoylphosphatidylcholine), which exhibits gel/fluid phase coexistence for wide temperature and composition ranges, was studied using photophysical techniques, namely fluorescence anisotropy, lifetime and resonance energy transfer (FRET) measurements. The FRET donor, N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)-dilauroylphosphatidylethanolamine, and a short-tailed FRET acceptor, 1,1′-didodecil-3,3,3′,3′-tetramethylindocarbocyanine (DiIC12(3)), were shown to prefer the fluid phase by both intrinsic anisotropy, lifetime and FRET measurements, in agreement with published reports. The other studied FRET acceptor, long-tailed probe 1,1′-dioctadecil-3,3,3′,3′-tetramethylindocarbocyanine (DiIC18(3)), is usually reported in the literature as partitioning mainly to the gel. While intrinsic lifetime studies indeed indicated preferential partition of DiIC18(3) into a rigidified environment, FRET analysis pointed to an increased donor-acceptor proximity as a consequence of phase separation. These apparently conflicting results were rationalized on the basis of segregation of DiIC18(3) to the gel/fluid interphase. In order to fluid-located donors sense these interphase-located acceptors, fluid domains should be small (not exceed ~10-15 nm). It is concluded that membrane probes which apparently prefer the gel phase may indeed show a non-random distribution in this medium, and tend to locate in an environment which simultaneously leads to less strict packing constraints and to favorable hydrophobic matching interactions. Energy transfer/ Gel/fluid heterogeneity/ Fluorescence/ Membrane domain/ Membrane probe/ Partition

Lourens, J. H. M. and Lyaruu, D. M. (1979). Susceptibility of Some East African Strains of Rhipicephalus appendiculatus to Cholinesterase Inhibiting Acaricides. PANS (Pest Artic.News Summ.) 25: 135-142.

EcoReference No.: 72641

Chemical of Concern: CBL,CPY,DZ; Habitat: T; Effect Codes: MOR; Rejection Code: TARGET(DZ).

LOVATT, J. (1991). GROWING PUMPKINS GRAMMAS AND WATERMELONS IN QUEENSLAND. LOVATT, J. GROWING PUMPKINS, GRAMMAS AND WATERMELONS IN QUEENSLAND. IV+44P. QUEENSLAND DEPARTMENT OF PRIMARY INDUSTRIES: BRISBANE, QUEENSLAND, AUSTRALIA. ILLUS. PAPER. ISBN 0-7242-3995-2.; 0 IV+44P.

Chem Codes : Chemical of Concern: DZ Rejection Code: NO TOX DATA.

BIOSIS COPYRIGHT: BIOL ABS. RRM BOOK CITRULLUS-LANATUS CUCURBITA-MAXIMA CUCURBITA-MOSCHATA TILLAGE FERTILIZER WEED CONTROL IRRIGATION POLLINATION INSECT PEST CONTROL DISEASE CONTROL PESTICIDES HARVESTING MARKETING AUSTRALIA Biochemistry/ Food, Formulated/ Food, Fortified/ Food Technology/ Biophysics/ Plants/Metabolism/ Plants/Physiology/ Water/Metabolism/ Grasses/Growth & Development/ Soil/ Fertilizers/ Soil/ Vegetables/ Environmental Pollution/ Plant Diseases/ Weather/ Plant Diseases/ Preventive Medicine/ Herbicides/ Pest Control/ Pesticides/ Arachnida/ Entomology/Economics/ Plants/ Arachnida/ Entomology/Economics/ Insecticides/ Pest Control/ Pesticides/ Plants

Lovatt, J. (1991). Growing Pumpkins Grammas and Watermelons in Queensland. In: J.Lovatt, Growing Pumpkins, Grammas and Watermelons in Queensland, Queensland Dep.of Primary Ind., Brisbane, Queensland, Australia 44 p.
Chem Codes: Chemical of Concern: TDF,Zineb,ALSV,DZ,ES,MLN,CuOH,CaPS,SFR,PRN Rejection Code: REFS CHECKED/REVIEW.

LOVELL RA, MCCHESNEY DG, and PRICE WD (1996). Organohalogen and organophosphorus pesticides in mixed feed rations: Findings from FDA's domestic surveillance during fiscal years 1989-1994. JOURNAL OF AOAC INTERNATIONAL; 79 544-548.

Chem Codes: Chemical of Concern: MCPP1 Rejection Code: DRUG.

BIOSIS COPYRIGHT: BIOL ABS. During Fiscal Years 1989-1994, the U.S. Food and Drug Administration (FDA) collected and analyzed 545 domestic surveillance samples of mixed feed rations (172 for cattle, 125 for poultry, 83 for swine, 61 for pets, 56 for fish, and 48 miscellaneous). All samples were analyzed by gas-liquid chromatography for organohalogen and organophosphorus pesticides. Of the 545 samples, 88 (16.1%) did not contain detectable pesticide residues. In the 457 samples with detectable pesticide levels, 804 residues (654 quantitable and 150 trace) were found. None of these 804 residues exceeded regulatory guidance. Malathion, chlorpyrifosmethyl, diazinon, chlorpyrifos, and pirimiphos-methyl were the most commonly detected pesticides. These 5 organophosphorus pesticides accounted for 93.4% of all pesticide residues detected (malathon, 52.9%; chlorpyrifos-methyl, 25.2%; diazinon, 7.7%; chlorpyrifos, 4.9%; and pirimiphos-methyl, 2.7%). Their median values in samples containing quantitable leve Biochemistry/ Food Technology/ Food Technology/ Fruit/ Nuts/ Vegetables/ Fats/ Food Technology/ Oils/ Food Analysis/ Food Technology/ Food Additives/Poisoning/ Food Additives/Toxicity/ Food Contamination/ Food Poisoning/ Food Preservatives/Poisoning/ Food Preservatives/Toxicity/ Carcinogens/ Animal Feed/ Animal Nutrition/ Feeding Behavior/ Herbicides/ Pest Control/ Pesticides/ Arachnida/ Entomology/Economics/ Insecticides/ Pest Control/ Pesticides

LOVELL RA, MCCHESNEY DG, and PRICE WD (1996). Organohalogen and organophosphorus pesticides in mixed feed rations: Findings from FDA's domestic surveillance during fiscal years 1989-1994. JOURNAL OF AOAC INTERNATIONAL; 79 544-548.
Chem Codes: Chemical of Concern: DZ Rejection Code: HUMAN HEALTH.

BIOSIS COPYRIGHT: BIOL ABS. During Fiscal Years 1989-1994, the U.S. Food and Drug Administration (FDA) collected and analyzed 545 domestic surveillance samples of mixed feed rations (172 for cattle, 125 for poultry, 83 for swine, 61 for pets, 56 for fish, and 48 miscellaneous). All samples were analyzed by gas-liquid chromatography for organohalogen and organophosphorus pesticides. Of the 545 samples, 88 (16.1%) did not contain detectable pesticide residues. In the 457 samples with detectable pesticide levels, 804 residues (654 quantitable and 150 trace) were found. None of these 804 residues exceeded regulatory guidance. Malathion, chlorpyrifosmethyl, diazinon, chlorpyrifos, and pirimiphos-methyl were the most commonly detected pesticides. These 5 organophosphorus pesticides accounted for 93.4% of all pesticide residues detected (malathon, 52.9%; chlorpyrifos-methyl, 25.2%; diazinon, 7.7%; chlorpyrifos, 4.9%; and pirimiphos-methyl, 2.7%). Their median values in samples containing quantitable leve Biochemistry/ Food Technology/ Food Technology/ Fruit/ Nuts/ Vegetables/ Fats/ Food Technology/ Oils/ Food Analysis/ Food Technology/ Food Additives/Poisoning/ Food Additives/Toxicity/ Food Contamination/ Food Poisoning/ Food Preservatives/Poisoning/ Food Preservatives/Toxicity/ Carcinogens/ Animal Feed/ Animal Nutrition/ Feeding Behavior/ Herbicides/ Pest Control/ Pesticides/ Arachnida/ Entomology/Economics/ Insecticides/ Pest Control/ Pesticides

Lowden, G. F., Saunders, C. L., and Edwards, R. W. (1969). Organo-Chlorine Insecticides in Water - Part II. Water Treat.Exam. 18: 275-287.
Chem Codes: EcoReference No.: 65475
Chemical of Concern: DZ Rejection Code: EFFLUENT.

Lown, J. William and Mclaughlin, Larry W. (1979). Nitrosourea-induced DNA single-strand breaks. Biochemical Pharmacology 28: 1631-1638.

Chem Codes: Chemical of Concern: DZ Rejection Code: IN VITRO.

Reaction of DNA with nitrosoureas in vitro results in extensive formation of alkali labile sites. Two types of single-strand scission (SSS) processes may be distinguished by their different rates: (1) type I SSS which occurs relatively fast at high pH, and (2) type II SSS which is a much slower process. Neither of these processes is affected by free radical traps. Dimethyl sulfate, which is known to alkylate DNA bases but not phosphate residues, shows no type I SSS but does show extensive type II SSS. That the latter process involves alkylation of bases followed by the formation of apurinic sites was confirmed by using endonuclease VI, an enzyme specific for apurinic positions. Reactions of chloroethylnitrosoureas with DNA produces both type I and type II SSS. Aliphatic amines produced in the decomposition of alkyl nitrosoureas do not contribute significantly to the scission of apurinic sites via Schiff base formation. However, this process may be significant for aryl nitrosoureas. Ethyl nitrosourea (ENU), 1, 3-bis(2-chloroethyl)nitrosourea (BCNU), and 3-cyclohexyl-1-(2-hydroxyethyl)-1-nitrosourea (CHNU) readily degrade poly A by phosphate alkylation, with rates that parallel their relative rates of decomposition. The relative rates of hydrolysis of triethylphosphate and [beta]-hydroxyethyl diethyl phosphate parallel the type I SSS observed for ENU and CHNU with DNA. The type I SSS of DNA by these compounds appears to involve a similar phosphotriester formation and hydrolysis. The type I SSS is in accord with the observed extreme liability of [beta]-hydroxyethyl diethyl phosphate which is attributed to participation of the OH group, and by the fact that methylation of the OH completely inhibits the type I SSS process.

Lu Chensheng, Irish, R. M., and Fenske, R. A. (2003). Biological monitoring of diazinon exposure using saliva in an animal model. Journal of Toxicology and Environmental Health, Part A: Current Issues [J. Toxicol. Environ. Health, A: Curr. Iss.]. Vol. 66, no. 24, pp. 2315-2325. 26 Dec 2003.
Chem Codes: Chemical of Concern: DZ Rejection Code: SURVEY.

ISSN: 1528-7394

Descriptors: Saliva
Descriptors: Diazinon
Descriptors: Plasma
Descriptors: Pesticides
Abstract: Alternative biological monitoring methods are currently being pursued to better quantify pesticide exposures. In this study, the feasibility of using saliva as a tool for measuring diazinon exposure was determined in an animal model. Male Spraque-Dawley rats were dosed with 1 or 10 mg/kg diazinon by bolus intravenous injection. Time-matched saliva and arterial blood samples were collected from 10 to 250 min post administration. Diazinon was distributed and eliminated rapidly in rats following intravenous (iv) bolus injection, according to a two-compartmental pharmacokinetic analysis. Salivary concentration of diazinon showed a strong correlation with plasma concentration of diazinon. The saliva/plasma (S/P) concentration ratio of diazinon was not affected by administered dose, sampling time, or salivary flow rate, suggesting that salivary excretion of diazinon in rats is fairly constant. Diazinon concentrations in saliva were consistently lower than those in arterial plasma. The mean S/P concentration ratios of diazinon were 0.16 and 0.13 for 1 and 10 mg/kg iv bolus doses, respectively. It is most likely that the incomplete transfer of diazinon from plasma to saliva is due to protein binding of diazinon in plasma. If the protein-unbound fraction of diazinon in plasma is used to calculate the S/P ratio, the S/P concentration ratio of diazinon is close to unity. The results from this study support the conclusion that diazinon salivary concentrations not only can be used to predict the plasma levels of diazinon in rats, but also reflect the unbound fraction of diazinon in plasma.
DOI: 10.1080/15287390390244328
Language: English
English
Publication Type: Journal Article
Classification: X 24133 Metabolism
Subfile: Toxicology Abstracts

Ludemann, D. and Neumann, H. (1961). Action of Modern Insecticides on the Organisms in Freshwater (Versuche uber die Acute Toxische Wirkung Neuzeitlicher Kontaktinsektizide auf Susswassertiere). Z.Angew.Zool. 48: 87-96 (GER) (ENG ABS).

EcoReference No.: 10346

Chemical of Concern: DZ,HCCH,MLN,DLD,CHD; Habitat: A; Effect Codes: ACC,MOR; Rejection Code: NO FOREIGN.

Ludemann, D. and Neumann, H. (1960). Acute Toxicity of Modern Contact Insecticides to Carp. Z.Angew.Zool.47:11-33 (GER).

EcoReference No.: 10347

Chemical of Concern: DZ,HCCH,MLN,EN,HPT,DDT,CHD,DLD,TXP,AND; Habitat: A; Effect Codes: MOR; Rejection Code: NO FOREIGN.

Ludemann, D. and Neumann, H. (1960). Studies on the Acute Toxicity of Modern Contact Insecticides in Fresh Water. II. Z.Angew.Zool. 47: 303-321 (GER) (ENG ABS).

EcoReference No.: 17488

Chemical of Concern: DZ,HCCH,MLN,TXP; Habitat: A; Effect Codes: MOR; Rejection Code: NO FOREIGN.

Ludemann, D. and Neumann, H. (1960). Studies on the Acute Toxicity of Modern Contact Insecticides in Fresh Water. III. Chironomid Larvae. Z.Angew.Zool. 47: 493-505 (GER).

EcoReference No.: 17489

Chemical of Concern: HPT,EN,HCCH,PRN,DDT,ES,TXP,CHD,AND,DZ,MLN; Habitat: A; Effect Codes: MOR; Rejection Code: NO FOREIGN.

Ludemann, D. and Neumann, H. (1962). Uber die Wirkung der Neuzeitlichen Kontaktinsektizide auf die Tiere des Subwassers. Anz.Schaedlingskd.Pflanzenschutz 35: 5-9 (GER).

EcoReference No.: 14258

Chemical of Concern: DZ,HCCH,MLN; Habitat: A; Effect Codes: MOR; Rejection Code: NO FOREIGN.

M. Afonso, Carlos, Teresa Barros, M., S. Godinho, Licio, and D. Maycock, Christopher (1994). The mechanism of the Mitsunobu azide modification and the effect of additives on the rate of hydroxyl group activation. Tetrahedron 50: 9671-9678.

Chem Codes: Chemical of Concern: DZ Rejection Code: METHODS.

The Mitsunobu azide modification has been studied by NMR using a hindered alcohol and the principle intermediates involved have been tentatively identi

Maas, J. L. (1982). Toxicity of Pesticides. Rep.No.82, Lab.for Ecotoxicol., Inst.for Inland Water Manag.and Waste Water Treatment 15: 4 p.(DUT).

EcoReference No.: 5370

Chemical of Concern: CBL,DMT,DZ,MLN; Habitat: A; Effect Codes: MOR; Rejection Code: NO FOREIGN.

Mac-Rae, I. C. and Celo, Jovenia S. (1974). The effects of organo-phosphorus pesticides on the respiration of Azotobacter vinelandii. Soil Biology and Biochemistry 6: 109-111.

Chem Codes: Chemical of Concern: DZ Rejection Code: BACTERIA.

The effects often organo-phosphorus pesticides at 2 and 100 parts/106 upon O2-uptake of Azotobacter vinelandii with glucose as substrate was studied by means of polarography. When washed suspensions of the bacterium were exposed to the pesticides for 2 h before measurement of oxygen uptake. respiration rate was greatly reduced in the case of Naled, Terracur-P, Coumaphos. DDVP, Malathion. Nemacur-P, Chlorpyrifos, DOWCO 217 and DOWCO 214 at 100 parts/106 concn. At 2 parts/106, respiration was inhibited with Naled, Coumaphos, DDVP, Chlorpyrifos and to a lesser extent with DOWCO 217 and Nemacur-P. No inhibition was found with Terracur-P, or DOWCO 214 at 2 parts/106 concn. Malathion stimulated respiration at 2 parts/106 concn whereas Diazinon stimulated respiration at both concentrations. Endogenous respiration was stimulated by Naled at 2 parts/106 and by Nemacur-P and DDVP at both the concentrations. The effect on respiration was less when the bacterium was grown in the presence of 100 parts/106 DDVP or Naled, but in the case of Terracur-P there was still a marked inhibition.

MACALADY DL and WOLFE NL ( 1985). EFFECTS OF SEDIMENT SORPTION AND ABIOTIC HYDROLYSES 1. ORGANOPHOSPHOROTHIOATE ESTERS. J AGRIC FOOD CHEM; 33 167-173.
Chem Codes: Chemical of Concern: DZ Rejection Code: FATE.

BIOSIS COPYRIGHT: BIOL ABS. RRM RONNEL DIAZINON CHLORPYRIFOS INSECTICIDE MH - ECOLOGY Oceanography/ Fresh Water/ Biochemistry/ Poisoning/ Animals, Laboratory/ Soil/ Herbicides/ Pest Control/ Pesticides/ Arachnida/ Entomology/Economics/ Insecticides/ Pest Control/ Pesticides

MacCuaig, R. D. (1963). The Toxicity of Some Insecticidal Sprays to Adult Locusts. Bull.Entomol.Res. 53: 597-608.

EcoReference No.: 71175

Chemical of Concern: DZ,DLD; Habitat: T; Rejection Code: TARGET(DZ).

MacCuaig, R. D. (1960). The Toxicity of Some Insecticides to Fifth-Instar Nymphs of the Desert Locust. Ann.Appl.Biol. 48: 323-335.

EcoReference No.: 72004

Chemical of Concern: DZ,DLD,PRN,HPT,HCCH; Habitat: T; Effect Codes: MOR,GRO; Rejection Code: TARGET(DZ).

Macek, K. J. (1975). Acute Toxicity of Pesticide Mixtures to Bluegills. Bull.Environ.Contam.Toxicol. 14: 648-651.

Chem Codes: EcoReference No.: 14625
Chemical of Concern: DZ Rejection Code: MIXTURE.

Machin, A. F., Quick, M. P., Rogers, H., and Anderson, P. H. (1971). The Conversion of Diazinon to Hydroxydiazinon in the Guinea-Pig and Sheep. Bull.Environ.Contam.Toxicol. 6: 26-27.

EcoReference No.: 37787

Chemical of Concern: DZ; Habitat: T; Effect Codes: BCM; Rejection Code: NO ENDPOINT(DZ).

MacIntosh, D. L., Spengler, J. D., Oezkaynak, H. , Tsai Ling-hui, and Ryan, P. B. (1996). Dietary exposures to selected metals and pesticides. Environmental Health Perspectives [ENVIRON. HEALTH PERSPECT.]. Vol. 104, no. 2, pp. 202-209. 1996.

Chem Codes: Chemical of Concern: DZ Rejection Code: HUMAN HEALTH.

ISSN: 0091-6765

Descriptors: diets
Descriptors: metals
Descriptors: pesticides
Descriptors: food contamination
Descriptors: heavy metals
Descriptors: USA
Abstract: Average daily dietary exposures to 11 contaminants were estimated for approximately 120,000 U.S. adults by combining data on annual diet, as measured by a food frequency questionnaire, with contaminant residue data for table-ready foods that were collected as part of the annual U.S. Food and Drug Administration Total Diet Study. The contaminants included in the analysis were four heavy metals (arsenic, cadmium, lead, mercury), three organophosphate pesticides (chlorpyrifos, diazinon, malathion), and four organochlorine pesticides (dieldrin, p,p'-DDE, lindane, heptachlor epoxide). Dietary exposures to these contaminants were highly variable among individuals, spanning two to three orders of magnitude. Intraindividual exposures to the metals, organophosphates, and organochlorines were estimated to be strongly correlated; Pearson's correlation coefficients ranged from 0.28 for lindane:dieldrin to 0.84 for lead:mercury. For some of the compounds (e.g., arsenic and dieldrin), a substantial fraction of the population was estimated to have dietary intakes in excess of health-based standards established by the EPA. Before use for risk assessment or epidemiologic purposes, however, the validity of the exposure estimates must be evaluated by comparison with biological indicators of chronic exposure. Because of their low detection rate in table-ready foods, the estimated distributions of exposures for dieldrin, p,p'-DDE, heptachlor epoxide, lindane, diazinon, and chlorpyrifos were found to be sensitive to assumed values for nondetect samples. Reliable estimates of the population distribution of dietary exposures to most other contaminants cannot be made currently, due to their low rate of detection in table-ready foods. Monitoring programs that use more sensitive study designs and population-based assessments for other subpopulations should be a priority for future research.
Other numbers: NIH 96-218
Language: English
English
Publication Type: Journal Article
Classification: X 24120 Food, additives & contaminants
Classification: P 6000 TOXICOLOGY AND HEALTH
Classification: H SE4.24 FOOD CONTAMINATION
Classification: R2 23060 Medical and environmental health
Classification: X 24166 Environmental impact
Classification: X 24136 Environmental impact
Subfile: Risk Abstracts; Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts

MACIVER DR, KEANE PA, JONES DG, and JONES AG (1997). Pyrethrins and piperonyl butoxide as public health insecticides. PYRETHRUM POST; 20 3-46.

Chem Codes: Chemical of Concern: DZ Rejection Code: REVIEW.

BIOSIS COPYRIGHT: BIOL ABS. RRM LITERATURE REVIEW MOSQUITO HOUSEFLY FLEA COCKROACH TICK LOUSE MITE INSECT PEST VECTOR VECTOR CONTROL PIPERONYL BUTOXIDE APPLICATION FIELD USE ENVIRONMENTAL EFFECTS EFFICACY FORMULATION COMPARISON INSECTICIDE TOXICITY TESTING SAFETY PUBLIC HEALTH PEST MANAGEMENT VECTOR BIOLOGY WORLD HEALTH CARE VECTOR-BORNE DISEASE DISEASE-MISCELLANEOUS CONTROL Poisoning/ Animals, Laboratory/ Disease Vectors/ Disinfection/ Pest Control/ Pesticides/ Disease Vectors/ Herbicides/ Pest Control/ Pesticides/ Animals/ Arachnida/ Entomology/Economics/ Pest Control/ Arachnida/ Entomology/Economics/ Insecticides/ Pest Control/ Pesticides/ Insects/ Diptera/ Orthoptera/ Fleas/ Arthropods

MacKenzie, K. E. and Winston, M. L. (1989). The Effects of Sublethal Exposure to Diazinon, Carbaryl and Resmethrin on Longevity and Foraging in Apis mellifera L. Apidologie 20: 29-40.

EcoReference No.: 70542

Chemical of Concern: RSM,DZ,CBL; Habitat: T; Effect Codes: MOR,BEH; Rejection Code: LITE EVAL CODED(RSM),OK(ALL CHEMS),OK TARGET(DZ).

Mackness, B., Durrington, P. N., and Mackness, M. I. (2000). Low Paraoxonase in Persian Gulf War Veterans Self-Reporting Gulf War Syndrome. Biochemical and Biophysical Research Communications [Biochem. Biophys. Res. Commun.]. Vol. 276, no. 2, pp. 729-733. 24 Sep 2000.

Chem Codes: Chemical of Concern: DZ Rejection Code: HUMAN HEALTH.

ISSN: 0006-291X

Descriptors: Paraoxon
Descriptors: Chemical warfare agents
Descriptors: Pesticides (organophosphorus)
Descriptors: Military personnel
Abstract: Exposure to organophosphate (OP's) insecticides and nerve gases during the Persian Gulf War has been implicated in the development of Gulf War Syndrome. Paraoxonase (PON1) present in human serum detoxifies OP's. We determined the levels of PON1 in the serum of Gulf War Veterans and compared these to those found in a control population. One hundred fifty-two Gulf War Veterans from the UK who self-reported the presence of Gulf War Syndrome via a questionnaire and 152 age and gender matched controls were studied. PON1 activity, concentration, and genotype were determined. In the Gulf War Veterans, paraoxon hydrolysis was less than 50% of that found in the controls (100.3 (14.8-233.8) vs 214.6 (50.3-516.2) nmol/min /ml, P < 0.001). This low activity was independent of the effect of PON1 genotype. The serum PON1 concentration was also lower in the Gulf War Veterans (75.7 (18.1-351.3) vs 88.2 (34.5-527.4) mu g /ml, P < 0.00025), which was again independent of PON1 genotype. There was no difference in the rate of diazoxon hydrolysis between the groups (10.2 plus or minus 4.1 mu mol/min/ml vs 9.86 plus or minus 4.4, P = NS). A decreased capacity to detoxify OP insecticides resulting from low serum PON1 activity may have contributed to the development of Gulf War Syndrome.
Publisher: Academic Press
DOI: 10.1006/bbrc.2000.3526
Language: English
English
Publication Type: Journal Article
Classification: X 24135 Biochemistry
Subfile: Toxicology Abstracts

MacPhee, C. and Ruelle, R. (1969). Lethal Effects of 1888 Chemicals upon Four Species of Fish From Western North America. Bull.No.3, Forest, Wildl.and Range Exp.Stn., Univ.of Idaho, Moscow, ID 112 p.

EcoReference No.: 15148

Chemical of Concern: PNB,24DXY,Captan,CBL,DOD,HCCH,MLN,NYP,CST,WFN,FUR,Cu,CuS,NaN3,CuCl,PCP,ACL,ATM,Se,DBAC,Zn,DZ,Pb,DCB; Habitat: A; Effect Codes: MOR,BEH; Rejection Code: NO CONTROL(ALL CHEMS).

Madhukar, B. V. and Matsumura, F. (1979). Comparison of Induction Patterns of Rat Hepatic Microsomal Mixed-Function Oxidases by Pesticides and Related Chemicals. Pestic.Biochem.Physiol. 11: 301-308.