N., and Bakry, N. M. (2006)

Chem Codes: Chemical of Concern: DZ Rejection Code: METHODS.

The interactions of the hydrophobic pulmonary surfactant proteins, SP-C and SP-B, with lipid bilayers were assessed by fluorescence energy transfer. SP-C and SP-B were labeled with the fluorescent probe, succinimidyl nitrobenzoxadiazolyl amino hexanoate (NBD). Fluorescence energy transfer from NBD-SP-C and NBD-SP-B to four distinct indocarbocyanine probes (CnDiI) was utilized to determine the association of the surfactant proteins with various lipid acyl chains. In lipid mixtures including DPPC and DPPG, SP-C was associated with shorter chain and unsaturated lipids below the bulk lipid phase transition. Longer chain saturated CnDiI were excluded from SP-C aggregates. In contrast, SP-B demonstrated little acyl chain preference. The association of SP-C with shorter chain and unsaturated lipids below the bulk phase transition is interpreted to arise from a mismatch in the length of the hydrophobic region of the SP-C a-helix relative to the length of the hydrophobic region of dipalmitoyl lipids in the gel phase. Pulmonary surfactant/ Acyl chain length/ Energy transfer/ Indocarbocyanine dye

Horowitz, Ann D., Elledge, Barry, Whitsett, Jeffrey A., and Baatz, John E. (1992). Effects of lung surfactant proteolipid SP-C on the organization of model membrane lipids: A fluorescence study. Biochimica et Biophysica Acta (BBA) - Biomembranes 1107: 44-54.
Chem Codes: Chemical of Concern: DZ Rejection Code: METHODS.

Lipid-protein interactions of pulmonary surfactant-associated protein SP-C in model DPPC/DPPG and DPPC/DPPG/eggPC vesicles were studied using steady-state and time-resolved fluorescence measurements of two fluorescent phospholipid probes, NBD-PC and NBD-PG. These fluorescent probes were utilized to determine SP-C-induced lipid perturbations near the bilayer surface, and to investigate possible lipid headgroup-specific interactions of SP-C. The presence of SP-C in DPPC/DPPG membrane vesicles resulted in (1) a dramatic increase in steady-state anisotropy of NBD-PC and NBD-PG at gel phase temperatures, (2) a broadening of the gel-fluid phase transition, (3) a decrease in self-quenching of NBD-PC and NBD-PG probes, and (4) a slight increase in steady-state anisotropy of NBD-PG at fluid phase temperatures. Time-resolved measurements, as well as steady-state intensity measurements indicate that incorporation of SP-C into DPPC/DPPG or DPPC/DPPG/eggPC vesicles results in a increase in the fraction of the long-lifetime species of NBD-PC. The results presented here indicate that SP-C orders the membrane bilayer surface, disrupts acyl chain packing and may increase the lateral pressure within the bilayer. Surfactant/ Fluorescence/ Lipid-protein interaction/ Model membrane

HORTON BJ, BEST DJ, BUTLER LG, and GREGORY GG (1997). Organophosphorus residues in wool grease resulting from specified on-farm lice and flystrike control treatments. AUSTRALIAN VETERINARY JOURNAL; 75 500-503.
Chem Codes: Chemical of Concern: DZ Rejection Code: NO TOX DATA.

BIOSIS COPYRIGHT: BIOL ABS. Objective: To investigate wool organophosphorus concentrations resulting from a range of farm pesticide application methods. Design: Random sampling of wool for pesticide residues and on-farm interviews to determine associated treatments. Procedure: Tasmanian fleece wool lots were sampled at random and tested for organophosphorus residues. The grower was identified and the pesticide treatments applied to the sheep were ascertained by on-farm interview. Results: The residue concentrations showed a large variation that was not accounted for by differences in treatments by growers. Organophosphorus concentrations were proportional to the number of treatments applied, and inversely related to the time between pesticide application and the subsequent shearing, and were significantly influenced by the method of application. After allowing for the time of application, plunge dipping resulted in pesticide residue concentrations 2 to 2.5 times greater than shower dipping, using Animal Husbandry/ Herbicides/ Pest Control/ Pesticides/ Arachnida/ Entomology/Economics/ Insects

Hough, L. and Mufti, K. S. (1972). Sucrochemistry : Part VI. Further reactions of 6,6′--O-tosylsucrose and a comparison of the reactivity at the 6 and 6′ positions. Carbohydrate Research 25: 497-503.
Chem Codes: Chemical of Concern: DZ Rejection Code: METHODS.

Reaction of 6,6′-di-O-tosylsucrose hexa-acetate (1) with sodium chloride in hexamethylphosphoric triamide gave a mixture containing preponderantly the hexa-acetates of 6,6′-dichloro-6,6′-dideoxysucrose (2) and 6-chloro-6-deoxy-6′-O-tosyl-sucrose (3). Reaction of 3 with sodium benzoate in (Me2N)3PO gave the 6-chloro-6-deoxy-6′-O-benzoyl derivative 4. Subsequent O-de-esterification afforded syrupy 6-chloro-6-deoxysucrose (5), which gave a crystalline heptamethanesulphonate. The chloro groups in the heptabenzoate 7 and the hexa-acetate 2 were replaced by azide in (Me2N)3PO to give the corresponding derivatives of 6-azido-6-deoxysucrose (12) and 6,6′-diazido-6,6′-dideoxysucrose (8), respectively. O-De-esterification of the hexa-acetates 2 and 8 yielded the parent 6,6′-dichloride 6 and 6,6′-diazide 9, respectively. 6,6′-Di-O-tosylsucrose hexabenzoate (10) reacted with sodium bromide in (Me2N)3PO to give the 6,6′-dibromide 11, in high yield, which afforded 6-deoxy-[beta]--xylo-hex-5-enopyranosyl 6′-deoxy-[beta]--threo-hex-5′-enofuranoside hexabenzoate on treatment with silver fluoride in pyridine.

Hsiao Cheng-Ting, Yang Chen-Chang, Deng Jou-Fang, Bullard, M. J., and Liaw Shiumn-Jen (1996). Acute pancreatitis following organophosphate intoxication. Journal of Toxicology: Clinical Toxicology [J. TOXICOL.: CLIN. TOXICOL.] 34: 343-347.
Chem Codes: Chemical of Concern: DMT Rejection Code: HUMAN HEALTH.

Acute pancreatitis as a complication of organophosphate intoxication has been infrequently addressed. Previous reports have suggested that acute pancreatitis may follow the oral ingestion of several organophosphates, including parathion, malathion, difonate, coumaphos, and diazinon, or after cutaneous exposure to dimethoate. No cases of acute pancreatitis following mevinphos (CAS 7786-34-71) poisoning have been reported to date. The possible pathogeneses of the pancreatic insult in organophosphate intoxication are excessive cholinergic stimulation of the pancreas and ductular hypertension. We describe a patient presenting with painless acute pancreatitis following an intentional ingestion of large amounts of mevinphos. Serum amylase and lipase values were increased and determination of amylase isoenzymes confirmed a pancreatic origin. A computerized tomograph of the abdomen showed diffuse swelling of the pancreas. The patient was discharged after a seven week clinical course, complicated by a delayed neuropathy. As acute pancreatitis in organophosphate intoxication may be more common than reported, serum pancreatic enzymes and appropriate imaging studies should be more liberally utilized. Early recognition and appropriate therapy for acute pancreatitis may lead to an improved prognosis. Classification: X 24131 Acute exposure; H SE4.20 POISONS AND POISONING mevinphos/ pesticides (organophosphorus)/ pancreatitis/ organophosphorus compounds/ pesticides

Hsiao Cheng-Ting, Yang Chen-Chang, Deng Jou-Fang , Bullard, M. J., and Liaw Shiumn-Jen (1996). Acute pancreatitis following organophosphate intoxication. Journal of Toxicology: Clinical Toxicology [J. TOXICOL.: CLIN. TOXICOL.]. Vol. 34, no. 3, pp. 343-347. May 1996.
Chem Codes: Chemical of Concern: DZ Rejection Code: HUMAN HEALTH.

ISSN: 0731-3810

Descriptors: pancreatitis
Descriptors: pesticides
Descriptors: organophosphorus compounds
Abstract: Acute pancreatitis as a complication of organophosphate intoxication has been infrequently addressed. Previous reports have suggested that acute pancreatitis may follow the oral ingestion of several organophosphates, including parathion, malathion, difonate, coumaphos, and diazinon, or after cutaneous exposure to dimethoate. No cases of acute pancreatitis following mevinphos (CAS 7786-34-71) poisoning have been reported to date. The possible pathogeneses of the pancreatic insult in organophosphate intoxication are excessive cholinergic stimulation of the pancreas and ductular hypertension. We describe a patient presenting with painless acute pancreatitis following an intentional ingestion of large amounts of mevinphos. Serum amylase and lipase values were increased and determination of amylase isoenzymes confirmed a pancreatic origin. A computerized tomograph of the abdomen showed diffuse swelling of the pancreas. The patient was discharged after a seven week clinical course, complicated by a delayed neuropathy. As acute pancreatitis in organophosphate intoxication may be more common than reported, serum pancreatic enzymes and appropriate imaging studies should be more liberally utilized. Early recognition and appropriate therapy for acute pancreatitis may lead to an improved prognosis.
Language: English
English
Publication Type: Journal Article
Classification: X 24131 Acute exposure
Classification: H SE4.20 POISONS AND POISONING
Subfile: Health & Safety Science Abstracts; Toxicology Abstracts

Huang, T. H. Jackson, Yang, Dun-Sheng, Plaskos, Nicholas P., Go, Sandy, Yip, Christopher M., Fraser, Paul E., and Chakrabartty, Avijit (2000). Structural studies of soluble oligomers of the alzheimer [beta]-amyloid peptide. Journal of Molecular Biology 297: 73-87.

Chem Codes: Chemical of Concern: DZ Rejection Code: METHODS.

Recent studies have suggested that non-fibrillar soluble forms of A[beta] peptides possess neurotoxic properties and may therefore play a role in the molecular pathogenesis of Alzheimer’s disease. We have identified solution conditions under which two types of soluble oligomers of A[beta]40 could be trapped and stabilized for an extended period of time. The first type of oligomers comprises a mixture of dimers/tetramers which are stable at neutral pH and low micromolar concentration, for a period of at least four weeks. The second type of oligomer comprises a narrow distribution of particles that are spherical when examined by electron microscopy and atomic force microscopy. The number average molecular mass of this distribution of particles is 0.94 MDa, and they are are stable at pH 3 for at least four weeks. Circular dichroism studies indicate that the dimers/tetramers possess irregular secondary structure that is not [alpha]-helix or [beta]-structure, while the 0.94 MDa particles contain [beta]-structure. Fluorescence resonance energy transfer experiments indicate that A[beta]40 moieties in amyloid fibrils or protofibrils are more similar in structure to those in the 0.94 MDa particles than those in the dimers/tetramers. These findings indicate that soluble oligomeric forms of A[beta] peptides can be trapped for extended periods of time, enabling their study by high resolution techniques that would not otherwise be possible. amyloid/ fibril/ protein structure/ protofibril/ Alzheimer&rsquo/ s disease

Huang, Zhengping, Pearce, Kenneth H., and Thompson, Nancy L. (1992). Effect of bovine prothrombin fragment 1 on the translational diffusion of phospholipids in Langmuir-Blodgett monolayers. Biochimica et Biophysica Acta (BBA) - Biomembranes 1112: 259-265.
Chem Codes: Chemical of Concern: DZ Rejection Code: METHODS.

Previous work has shown that bovine prothrombin fragment 1 binds to supported planar membranes composed of phosphatidylcholine and phosphatidylserine in a Ca2+-specific manner (Tendian et al. (1991) Biochemistry 30, 10991; Pearce et al. (1992) Biochemistry 31, 5983-5995). In the present work, fluorescence pattern photobleaching recovery has been used to examine the effect of membrane-bound fragment 1 on the translational diffusion coefficients of two fluorescent phospholipids in fluid-like phosphatidylserine/phosphatidylcholine Langmuir-Blodgett monolayers. The results show that saturating concentrations of fragment 1, in the presence of Ca2+, reduce the diffusion coefficient of nitrobenzoxadiazolyl-conjugated phosphatidylserine (NBD-PS) and nitrobenzoxadiazolyl-conjugated phosphatidylcholine (NBD-PC) by factors of approximately four and two, respectively. Ca2+ or fragment 1 alone do not have a statistically significant effect on NBD-PS or NBD-PC diffusion. In addition, a nonspecific protein (ovalbumin) does not change the diffusion coefficients of the fluorescent phospholipids either in the absence or presence of Ca2+. The fractions of the fluorescent phospholipids that are laterally mobile are approximately 0.9 for all samples. These results are interpreted with several models for possible mechanisms by which extrinsically bound proteins might retard phospholipid diffusion in membranes. Thrombosis/ Hemostasis/ Blood coagulation/ Planar model membrane/ Fluorescesce photobleaching recovery/ Fluorescence microscopy/ Fluorescent phospholipid

Hudson, R. H., Haegele, M. A., and Tucker, R. K. (1979). Acute Oral and Percutaneous Toxicity of Pesticides to Mallards: Correlations with Mammalian Toxicity Data. Toxicol.Appl.Pharmacol. 47: 451-460.

EcoReference No.: 35259

Chemical of Concern: ADC,DEM,DCTP,EN,EP,FNT,FNTH,MP,MVP,PAQT,PRN,PRT,PPHD,DZ; Habitat: T; Effect Codes: MOR; Rejection Code: NO CONTROL(ALL CHEMS).

HUESKES, R. and LEVSEN, K. (1997). Pesticides in rain. CHEMOSPHERE; 35 3013-3024.

Chem Codes: Chemical of Concern: DZ Rejection Code: SURVEY.

BIOSIS COPYRIGHT: BIOL ABS. 40 rainwater samples were collected in Hannover and near Peine (Lower Saxony, Germany) in 1992 using a wet-only collector. The samples were extracted by solid phase extraction and analyzed by GC for 59 pesticides. 11 pesticides were found in more than 10 samples. The highest concentrations were observed for terbuthylazine (0.003-0.52 mug/L), metolachlor (0.003-0.51 mug/L, mean: 0.10 mug/L), metalaxyl (0.006-0.48 mug/L, mean: 0.10 mug/L) and chlorothalonil (0.003-1.1 mug/L, mean: 0.16 mug/L). The concentrations show a seasonal dependence reflecting the application periods./PHYSIOLOGY Climate/ Ecology/ Meteorological Factors/ Biochemistry/ Biophysics/ Macromolecular Systems/ Molecular Biology/ Air Pollution/ Soil Pollutants/ Water Pollution/ Herbicides/ Pest Control/ Pesticides

Hughes, Kenneth Andrew, Lahm, George Philip, Selby, Thomas Paul, and Stevenson, Thomas Martin (20040812). Preparation of cyano anthranilamide insecticides. 63 pp.
Chem Codes: Chemical of Concern: SPM,MAL,AZD,RTN Rejection Code: CHEM METHODS.

The title compds. [I; R1 = Me, Cl, Br, F; R2 = F, Cl, Br, haloalkyl or haloalkoxy; R3 = F, Cl, Br; R4 = H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, each optionally substituted with one substituent selected from the group consisting of halo, CN, SMe S(O)Me, S(O)2Me and OMe; R5 = H, Me; R6 = H, F, Cl; R7 = H, F, Cl], useful for controlling an invertebrate pest, were prepd. E.g., a multi-step synthesis of compd. I [R1 = Me; R2 = CF3; R3 = Cl; R4, R5 = H], was given. The compds. I were tested in various biol. tests (data given). This invention also pertains to a compn. for controlling an invertebrate pest comprising a biol. effective amt. of a compd. I, an N-oxide thereof or a suitable salt of the compd. I and at least one addnl. component selected from the group consisting of a surfactant, a solid diluent and a liq. diluent. [on SciFinder (R)] cyano/ anthranilamide/ prepn/ insecticide/ invertebrate/ pest Copyright: Copyright 2004 ACS on SciFinder (R))

Database: CAPLUS
Accession Number: AN 2004:648522
Chemical Abstracts Number: CAN 141:190786
Section Code: 28-8
Section Title: Heterocyclic Compounds (More Than One Hetero Atom)
CA Section Cross-References: 5
Coden: PIXXD2
Index Terms: Bacillus thuringiensis (co-administration with a member of Bacillus thuringiensis; prepn. of cyano anthranilamide insecticides); Macrolides Role: AGR (Agricultural use), BIOL (Biological study), USES (Uses) (co-administration with insecticidal macrocyclic lactone; prepn. of cyano anthranilamide insecticides); Hormones Role: BSU (Biological study, unclassified), BIOL (Biological study) (co-administration with juvenile hormone mimic; prepn. of cyano anthranilamide insecticides); GABA antagonists (co-administration with g-aminobutyric acid (GABA) antagonist; prepn. of cyano anthranilamide insecticides); Bacillus thuringiensis aizawai; Bacillus thuringiensis kurstaki; Baculoviridae (co-administration; prepn. of cyano anthranilamide insecticides for use in combination with other biol. active compds.); Microorganism (entomopathogenic, co-administration with entomopathogenic virus; prepn. of cyano anthranilamide insecticides for use in combination with other biol. active compds.); Eubacteria; Fungi (entomopathogenic, co-administration; prepn. of cyano anthranilamide insecticides for use in combination with other biol. active compds.); Tabanidae (horse fly, deer fly; prepn. of cyano anthranilamide insecticides for controlling the invertebrate pest); Acari; Araneae; Culicidae; Formicidae; Gnat; Simuliidae; Stomoxys calcitrans; Vespa; Vespula; Wasp (prepn. of cyano anthranilamide insecticides for controlling the invertebrate pest); Insecticides (prepn. of cyano anthranilamide insecticides for use in combination with other biol. active compds.); Pyrethrins Role: AGR (Agricultural use), BIOL (Biological study), USES (Uses) (pyrethroids, co-administration; prepn. of cyano anthranilamide insecticides); Toxins Role: AGR (Agricultural use), BIOL (Biological study), USES (Uses) (d-endotoxins, co-administration with a Bacillus thuringiensis d-endotoxin; prepn. of cyano anthranilamide insecticides)
CAS Registry Numbers: 57-13-6D (Urea) Role: AGR (Agricultural use), BIOL (Biological study), USES (Uses) (co-administration with insecticidal ureas; prepn. of cyano anthranilamide insecticides); 52-68-6 (Trichlorfon); 56-38-2 (Parathion); 60-51-5 (Dimethoate); 72-43-5 (Methoxychlor); 83-79-4 (Rotenone); 86-50-0 (Azinphosmethyl); 108-62-3 (Metaldehyde); 115-29-7 (Endosulfan); 115-32-2 (Dicofol); 116-06-3 (Aldicarb); 121-75-5 (Malathion); 298-00-0 (Parathionmethyl); 298-02-2 (Phorate); 333-41-5 (Diazinon); 510-15-6 (Chlorobenzilate); 732-11-6 (Phosmet); 950-37-8 (Methidathion); 1563-66-2 (Carbofuran); 2227-17-0 (Dienochlor); 2310-17-0 (Phosalone); 2312-35-8 (Propargite); 2439-01-2 (Chinomethionat); 2921-88-2 (Chlorpyrifos); 5598-13-0 (Chlorpyrifosmethyl); 6923-22-4 (Monocrotophos); 10265-92-6 (Methamidophos); 11141-17-6 (Azadirachtin); 13071-79-9 (Terbufos); 13121-70-5 (Cyhexatin); 13171-21-6 (Phosphamidon); 13356-08-6 (Fenbutatin oxide); 16752-77-5 (Methomyl); 22224-92-6 (Fenamiphos); 22248-79-9 (Tetrachlorvinphos); 23103-98-2 (Pirimicarb); 23135-22-0 (Oxamyl); 25311-71-1 (Isofenphos); 30560-19-1 (Acephate); 33089-61-1 (Amitraz); 35367-38-5 (Diflubenzuron); 35400-43-2 (Sulprofos); 39515-41-8 (Fenpropathrin); 40596-69-8 (Methoprene); 41198-08-7 (Profenofos); 51630-58-1 (Fenvalerate); 52207-48-4 (Thiosultapsodium); 52315-07-8 (Cypermethrin); 52645-53-1 (Permethrin); 52918-63-5 (Deltamethrin); 59669-26-0 (Thiodicarb); 62850-32-2 (Fenothiocarb); 63837-33-2 (Diofenolan); 64628-44-0 (Triflumuron); 66215-27-8 (Cyromazine); 66230-04-4 (Esfenvalerate); 66841-25-6 (Tralomethrin); 68085-85-8 (Cyhalothrin); 68359-37-5 (Beta-Cyfluthrin); 69327-76-0 (Buprofezin); 70124-77-5 (Flucythrinate); 71422-67-8 (Chlorfluazuron); 71751-41-2 (Abamectin); 72490-01-8 (Fenoxycarb); 73989-17-0 (Avermectin); 76703-62-3; 78587-05-0 (Hexythiazox); 79538-32-2 (Tefluthrin); 80060-09-9 (Diafenthiuron); 82657-04-3 (Bifenthrin); 83121-18-0 (Teflubenzuron); 84466-05-7 (Amidoflumet); 86479-06-3 (Hexaflumuron); 91465-08-6; 95737-68-1 (Pyriproxyfen); 96489-71-3 (Pyridaben); 101463-69-8 (Flufenoxuron); 102851-06-9 (Taufluvalinate); 103055-07-8 (Lufenuron); 111988-49-9 (Thiacloprid); 112226-61-6 (Halofenozide); 112410-23-8 (Tebufenozide); 116714-46-6 (Novaluron); 119168-77-3 (Tebufenpyrad); 119791-41-2 (Emamectin); 120068-37-3 (Fipronil); 120928-09-8 (Fenazaquin); 121451-02-3 (Noviflumuron); 122453-73-0 (Chlorfenapyr); 123312-89-0 (Pymetrozine); 129558-76-5 (Tolfenpyrad); 134098-61-6 (Fenpyroximate); 135410-20-7 (Acetamiprid); 138261-41-3 (Imidacloprid); 143807-66-3 (Chromafenozide); 149877-41-8 (Bifenazate); 153233-91-1 (Etoxazole); 153719-23-4 (Thiamethoxam); 158062-67-0 (Flonicamid); 161050-58-4 (Methoxyfenozide); 165252-70-0 (Dinotefuran); 170015-32-4 (Flufenerim); 173584-44-6 (Indoxacarb); 179101-81-6 (Pyridalyl); 181587-01-9 (Ethiprole); 201593-84-2 (Bistrifluron); 209861-58-5 (Acetoprole); 210880-92-5 (Clothianidin); 223419-20-3 (Profluthrin); 240494-70-6 (Metofluthrin); 283594-90-1 (Spiromesifen) Role: AGR (Agricultural use), BIOL (Biological study), USES (Uses) (co-administration; prepn. of cyano anthranilamide insecticides for use in combination with other biol. active compds.); 500011-03-0P; 736994-59-5P; 736994-60-8P; 736994-61-9P; 736994-62-0P; 736994-63-1P; 736994-64-2P; 736994-65-3P; 736994-66-4P; 736994-67-5P; 736994-68-6P; 736994-69-7P; 736994-70-0P; 736994-71-1P; 736994-72-2P; 736994-73-3P; 736994-74-4P; 736994-75-5P; 736994-76-6P; 736994-77-7P; 736994-78-8P; 736994-79-9P; 736994-80-2P; 736994-81-3P; 736994-82-4P; 736994-83-5P; 736994-84-6P; 736994-85-7P; 736994-86-8P; 736994-87-9P; 736994-88-0P; 736994-89-1P; 736994-90-4P; 736994-91-5P; 736994-92-6P; 736994-93-7P; 736994-94-8P; 736994-95-9P; 736994-96-0P; 736994-97-1P; 736994-98-2P; 736994-99-3P; 736995-00-9P; 736995-01-0P; 736995-02-1P; 736995-03-2P; 736995-04-3P; 736995-05-4P; 736995-06-5P; 736995-07-6P; 736995-08-7P; 736995-09-8P; 736995-10-1P; 736995-11-2P; 736995-12-3P; 736995-13-4P; 736995-14-5P; 736995-15-6P; 736995-16-7P; 736995-17-8P; 736995-18-9P; 736995-19-0P; 736995-20-3P; 736995-21-4P; 736995-22-5P; 736995-23-6P; 736995-24-7P; 736995-25-8P; 736995-26-9P; 736995-27-0P; 736995-28-1P; 736995-29-2P; 736995-30-5P; 736995-31-6P; 736995-32-7P; 736995-33-8P; 736995-34-9P; 736995-35-0P; 736995-36-1P; 736995-37-2P; 736995-38-3P; 736995-39-4P; 736995-40-7P; 736995-41-8P; 736995-42-9P; 736995-43-0P; 736995-44-1P; 736995-45-2P; 736995-46-3P; 736995-47-4P; 736995-48-5P; 736995-49-6P; 736995-50-9P; 736995-51-0P; 736995-52-1P; 736995-53-2P; 736995-54-3P; 736995-55-4P; 736995-56-5P; 736995-57-6P; 736995-58-7P; 736995-59-8P Role: AGR (Agricultural use), BSU (Biological study, unclassified), SPN (Synthetic preparation), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. of cyano anthranilamide insecticides); 2402-77-9 (2,3-Dichloropyridine); 6388-47-2 (2-Amino-3-chlorobenzoic acid); 20154-03-4 (3-Trifluoromethylpyrazole) Role: RCT (Reactant), RACT (Reactant or reagent) (prepn. of cyano anthranilamide insecticides); 4389-45-1P; 14339-33-4P; 14521-80-3P; 101012-31-1P; 438450-38-5P; 438450-39-6P; 458543-77-6P; 458543-78-7P; 458543-79-8P; 500008-69-5P; 500011-84-7P; 500011-85-8P; 500011-86-9P; 500028-90-0P; 736995-60-1P; 736995-61-2P; 736995-62-3P; 736995-63-4P; 736995-64-5P; 736995-65-6P; 736995-66-7P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. of cyano anthranilamide insecticides)
PCT Designated States: Designated States W: AE.
Patent Application Country: Application: WO
Priority Application Country: US
Priority Application Number: 2003-443256
Priority Application Date: 20030128

Hughes, P. B. (1982). Organophosphorus Resistance for the Sheep Blowfly, Lucilia cuprina (Wiedemann) (Diptera: Calliphoridae): A Genetic Study Incorporating Synergists. Bull.Entomol.Res. 72: 573-582.

EcoReference No.: 71767

Chemical of Concern: PRN,DZ; Habitat: T; Effect Codes: MOR; Rejection Code: TARGET(DZ).

Hughes, P. B. and Devonshire, A. L. (1982). The Biochemical Basis of Resistance to Organophosphorus Insecticides in the Sheep Blowfly, Lucilia cuprina. Pestic.Biochem.Physiol. 18: 289-297.