Genome Structure



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Геномнинг тузилиши

Genome Structure

  • Kinetics and Components

Genome

  • The genome is all the DNA in a cell.
  • Specifically, it is all the DNA in an organelle.
  • Eukaryotes can have 2-3 genomes
    • Nuclear genome
    • Mitochondrial genome
    • Plastid genome
  • If not specified, “genome” usually refers to the nuclear genome.

Genomics

  • Genomics is the study of genomes, including large chromosomal segments containing many genes.
  • The initial phase of genomics aims to map and sequence an initial set of entire genomes.
  • Functional genomics aims to deduce information about the function of DNA sequences.
    • Should continue long after the initial genome sequences have been completed.

Genomics vs. Genetics

  • Peter Goodfellow (1997, Nature Genetics 16:209-210): "...I would define genetics as the study of inheritance and genomics as the study of genomes. The latter informs the former and includes the sequencing of genomes. The concept of functional genetics is a tautology (the whole point of genetics is to link genes with phenotypes). Functional genomics is the attachment of information about function to knowledge of DNA sequence' paradoxically, genetics is a major tool for functional genomics."

Human genome

  • 22 autosome pairs + 2 sex chromosomes
  • 3 billion base pairs in the haploid genome
  • Where and what are the 30,000 to 40,000 genes?
  • Is there anything else interesting/important?
  • From NCBI web site, photo from T. Ried,
  • Natl Human Genome Research Institute, NIH

Components of the human Genome

  • Human genome has 3.2 billion base pairs of DNA
  • About 3% codes for proteins
  • About 40-50% is repetitive, made by (retro)transposition
  • What is the function of the remaining 50%?

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