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CURRICULUM VITAE
Name: Nathalie Scholler (née Buonavista), M.D., Ph.D.
Present Position: Tenure-track Assistant Professor, Department of Obstetrics and Gynecology.

Office: University of Pennsylvania School of Medicine.

Center for Research on Reproduction and Women's Health

Biomedical Research Building II/III, Room 1309

421 Curie Blvd., Philadelphia, PA, 19104-6160

Phone: (215) 898 0164 – Fax: (215) 573 5129 – email: naths@mail.med.upenn.edu

http://www.med.upenn.edu/crrwh/faculty/Scholler/Scholler.html

http://www.med.upenn.edu/schollerlab/
Place of Birth: Marseille, France

Education:

  1. PhD, Immunology University of Science of Aix-Marseille II, France

1990 Diplôme d’études approfondies (equiv. MS) University of Science of Aix-Marseille II, France.

In Immunology

1988 MD, General Medicine School of Medicine, Marseille, France.
Training:


    1. Post-Doctoral Fellowship Autoimmunity Department, Bristol Myers Squibb Pharmaceutical Institute, Seattle, WA

        1. PhD Thesis Centre d’Immunologie de Marseille-Luminy,

University of Aix-Marseille II, France.
1986-1988 Internship, General Medicine University of Aix-Marseille Affiliated Hospitals, Marseille, France.

Additional Training:

1993 Human genome analysis: from YAC to gene The 11th Welcome Summer School. United

Medical and Dental Schools of Guy’s and St Thomas’s Hospitals, London, UK

2004 Engineering of Recombinant Antibodies Cambridge Healthtech Institute, Needham, MA


Faculty Appointments and Professional Positions:

Nov. 2007-present Tenure-track Assistant Professor Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA

2003-2007 Senior Staff Scientist & Laboratory Director Translational and Outcomes Research laboratory, Molecular Diagnostics Program, Fred Hutchinson Cancer Research Center, Seattle, WA.

2001-2003 Senior Research Scientist Department of Biochemistry, Seattle Genetics, Inc. Bothell, WA.


    1. Staff Research Scientist Department of Tumor Immunology, Pacific Northwest Research Institute, Seattle, WA.

1990-1995 Sports Medicine Physician French National Federation of Judo, Marseille, Fr.

1989-1990 Physician Scientist French National Institute of Health and Medical

Research (INSERM), France and Brazil.

1988-1989 Resident, Internal Medicine St Joseph Hospital, Marseille, France.



Academic and Institutional committees

2010-present Penn Institute for Immunology (Penn IFI), UPenn Member

2010-present Bioengineering Graduate Studies, Bioengineering Graduate Group, UPenn Member

2009-present Biomedical Graduate Studies, Immunology Graduate Group, UPenn Member

2008-present FOCUS Advisory Committee, UPenn Member

2008-present Immunobiology program, Tumor Immunology Interest Group Full Research Member

Abramson Cancer Center, UPenn

2007-present Penn Ovarian Cancer Research Center (Penn OCRC), UPenn Member

Memberships:

2010-present American Association for Cancer Research (AACR)

2010-2011 New York Academy of Sciences (NYAS)

2008-present Consortium for Functional Glycomics (CFG)

2008-present Institute for Translational Medicine and Therapeutics (ITMAT)

2001-present American Association of Immunologists (AAI)

2001-present American Association for the Advancement of Science (AAAS)

2001-present American Society of Gene and Cell Therapy (ASGCT)

Scholarships, Fellowships and Awards:

2012 Early Carrier Faculty Travel Award American Association of Immunologists (AAI 2012)

Boston, MA.

2011 Junior Faculty Travel Award American Association of Immunologists (AAI 2011)

San Francisco, CA.

2003-2004 Career Development Award Marsha Rivkin Center for Ovarian Cancer Research

(MRCOCR), Seattle, WA.

2001-2003 Marsha Rivkin Center Scholar Award MRCOCR, Seattle, WA

1995 Private fellowship La Fondation pour la Recherche Médicale, France.



    1. National scholarship French Ministry of Research & Technology, France.

1990 Private fellowship La Fondation pour la Recherche Médicale, France.

    1. Regional scholarship Province des Bouches-du-Rhône, France.

Organizing roles

2011 Host Break-out discussion at the 13th Annual Phage and Yeast Display of Antibodies & Proteins conference, Protein Engineering Summit (PEGS) - May 9-10 - Boston, MA.

2010 Moderator Center for Research on Reproduction and Women’s Health Annual Research Retreat and the Cuozzo lecture- May 19- University of Pennsylvania, PA.

2010 Block Chair 97th AAI Annual meeting, Tumor Immune Response session - May 7-10 - Baltimore, MD

2009 Block Chair 96th AAI Annual meeting, Tumor Immune Escape - May 8-12 - Seattle, WA 

2008 Block Chair 2nd International Conference on Ovarian Cancer: State of the Art and Future Directions - June 26 - July 1- Rhodes, Greece



Scientific Review, Consulting and Advisory roles:

2012 Ad hoc reviewer for the Cancer Drug Discovery committee of the American Cancer Society

2011 Scientific reviewer for DOD Study section: Ovarian Cancer Research Program, Detection-Diagnosis and Clinical and Experimental Therapeutic, DD-CET

2011 Scientific expert for Wolf, Greenfield & Sacks, P.C., Boston, MA.

2011 Scientific reviewer for Kentucky Science & Engineering Foundation.

2010 Consultant for Reckner Healthcare.

2010 Advisory Board Member at the Editorial Board of Recent Patents on Biomarkers.

Since 2010 Advisory Board member for Cancer Targets and Therapeutics Annual Conferences.

2010 Scientific reviewer for the Health Research Council (HRC), New Zealand.

2010 Scientific reviewer for DOD Study section: Ovarian Cancer Clinical and Experimental Therapeutics.

2009-2011 Advisory Board tenured Member in the Editorial board of Journal of Proteome Research.

2009 Scientific reviewer for NIH Challenge grants in Health and Science Research (RC1).

2009 Scientific reviewer for The Health Research Board, Ireland.

2008 Scientific reviewer for Maryland Industrial Partnerships (MIPS).

2008 Scientific expert, Ernst & Young, Life and Health Science Advisory, Paris, France 

2008 Scientific reviewer for DOD Study section: Ovarian Cancer Research Program.

2008 Consultant for Ernst & Young Life and Health Science Advisory, Paris, France.

Editorial Positions

2012 Editorial Board Member Biomarkers

2012 Peer-Reviewer Cancer Biomarkers

2011-2014 Associate Editor BMC cancer

2011-present Peer-Reviewer Disease markers.

2011-present Peer-Reviewer OMICS: A Journal of Integrative Biology

2011-present Peer-Reviewer Nature Communications.

2011-present Peer-Reviewer Biomarkers in Medicine

2011-present Peer-Reviewer Molecular Pharmaceutics.

2011-present Peer-Reviewer Journal of Controlled Release.

2010-present Peer-Reviewer Cancer Immunology Immunotherapy.

2010-present Associate Editorial Board member Journal of Translational Research

2010-present Peer-Reviewer Journal of Proteomics

2009-present Peer-Reviewer Gynecologic Oncology

2009-present Peer-Reviewer PlosONE

2009-present Peer-Reviewer Clinical Science

2009-present Peer-Reviewer Cancer Epidemiology

2009-present Author-in-Chief Encyclopedia of Cancer, 2nd edition

2006-present Peer-Reviewer Cancer Letters

2008-present Peer-Reviewer Cancer Biology & Therapy

2008-present Peer-Reviewer Gynecologic and Obstetric Investigation

2008-present Peer-Reviewer Molecular and Cellular Proteomics


Presentations

2012 Poster presentation “Mannose receptor engagement by tumor-released mesothelin polarizes macrophages towards TAMs.” Abramson Cancer Center ACS Pilot Project Recognition Breakfast, April 16, 2012. University of Pennsylvania, PA

2012 Invited speaker “The coming of age of ovarian cancer biomarkers?” Biomarker Summit 2012, March 14-16, San Diego, CA

2011 Invited speaker “Novel mechanisms of polarization of tumor-infiltrating macrophages”. Complex Carbohydrate Research Center, University of Athens. December 5, Athens, GA.

2011 Invited speaker “Role of tumor-released glycoproteins during macrophage polarization”. Consortium for Functional Glycomics (CFG) breakout Session. November 9, Seattle, WA.

2011 Poster presentation “Development of T-bodies expressing CIR directed against Endosialin/TEM1 for immune-gene therapy against breast cancer”. Nathalie Scholler, Stephen P. Santoro, Shree Joshi, Aizhi Zhao, and George Coukos, Era of Hope 2011, August 2-5, Orlando, FL.

2011 Invited speaker “Paired yeast-display/secretory vectors for rapid isolation of site-specific biotinylated affinity reagents”, 13th Annual Phage and Yeast Display of Antibodies & Proteins conference, Protein Engineering Summit (PEGS) - May 9-10 - Boston, MA.

2011 Oral presentation “Tumor released mesothelin contributes to the polarization of tumor-infiltrating macrophages”, 14th Annual Meeting of the Translational Research Cancer Centers Consortium conference, Seven Springs Mountain Resort - Feb 24-26 - Seven Springs, PA

2011 Invited speaker “GPI anchors: much more than an alternative strategy for cell surface presentation” GTCbio’s 3rd Oncology Biomarker Conference, Jan 27-28, San Diego, CA.

2011 Poster presentation “Tumor-infiltrating B-cells express toll-like receptors and exert proangiogenic activity in ovarian cancer”. S. Nunez-Cruz, W. Quinn, D. Connolly, P. Gimotty, and N. Scholler. EMBO 2011 meeting. Immunology & Metabolism- Centre d’Immunologie de Marseille-Luminy, January 13-14, Marseille, France.

2010 Invited speaker “Role of B cells in cancer development”. 23rd Annual Immunology Retreat. November 5-7. Lancaster, PA
2010 Invited speaker “Novel mechanism for M2 polarization of tumor-infiltrating macrophages via GPI-anchored proteins”. Marsha Rivkin Center Ovarian Cancer Research Symposium, session: On the Horizon: Developing Therapeutics. Oct 28-29, Seattle, WA.

2010 Invited speaker “Tumor-infiltrating lymphocytes B (TIL-B) angiogenic properties contribute to tumor growth in presence of complement”. Department of Immunopathology, NIAID/NIH. June 3, Rockville, MD.

2010 Invited speaker “Study of the role of tumor-infiltrating B-cells in a transgenic mouse model of ovarian cancer”. Tumor Immunology Interest Group. May 20, University of Pennsylvania, PA.

2010 Poster presentation "Mannose receptor binding triggers M2-macrophage polarization" Denarda Dangaj, Selene Nunez-Cruz, Aizhi Zhao and Nathalie Scholler. Canary Foundation Early Detection Symposium, May 25-27, Stanford, CA

2009 Invited speaker “Alkali-resistant, site-specific biotinylated, high affinity reagent for IgG capture”. Bio-Rad laboratories, Dec. 9, Hercules, CA.

2009 Invited speaker “Tumor-infiltrating B lymphocytes in ovarian cancer”. FCCC-UPENN Quarterly Ovarian Cancer Research meeting. Fox Chase Cancer Research Center, Dec. 3, Philadelphia PA.

2009 Invited speaker “Study of the role of CA125 and adipocytes in the alternative complement pathway during ovarian cancer physiopathology” and “Blocking of CA125/Mesothelin-dependent peritoneal metastasis with antibodies and biobodies”. Fred Hutchinson Cancer Research Center, Scientific Program Committee Meeting. Nov 16, Seattle WA.

2009 Poster presentation "Blocking tumor/macrophages cross-talk with anti-mannose receptor recombinant antibodies to trigger tumor rejection" Denarda Dangaj, Aizhi Zhao, Raphael Sandaltzopoulos, George Coukos and Nathalie Scholler. 2009 NCI Translational Science Meeting (TSM 2), session: Therapeutic Antibodies and Combination Therapies, November 5-7, Vienna, VA.

2009 Poster presentation “Characterization of Tumor Infiltrating-B cells (TIL-B) in a transgenic mouse model of serous ovarian cancer.” Nunez-Cruz, S., Guerra, M., Queen, W., Scott P., Connolly, D., Cancro, M.P., Gimotty, P., and Scholler, N. Frontiers in Basic Immunology, NIH, October 1-2, Bethesda, MD.

2009 Invited speaker “Rapid identification of high affinity reagents using a yeast-expressed recombinant antibody

platform”, Dana Farber/Harvard Medical School, June 19, Boston, MA.

2009 Invited speaker “Systèmes d’expression d’anticorps recombinants dans la levure: Application en

Immunociblage”. INSERM -U 928- TAGC & UMR 928 Université de la Méditerranée, June 10, Marseille-Luminy, France.

2009 Invited speaker “Scouting glycoproteins in ovarian cancer”. CRRWH annual retreat, University of Pennsylvania, May 27, Philadelphia, PA.

2009 Invited speaker “Yeast-expressed recombinant antibody platform for rapid identification of high affinity reagents”. Institute of System Biology, May 11, Seattle, WA

2009 Invited speaker “Role of tumor-released GPI-anchor proteins in macrophage polarization”. Centocor, University of Pennsylvania, March 16, Philadelphia, PA

2009 Invited speaker “Biobody technology.” Drexel Institute for Biotechnology and Virology Research at Pennsylvania Biotechnology Center of Bucks County, March 11, Doylestown, PA.

2009 Invited speaker “Yeast-expressed recombinant antibody (scFv) for discovery of cancer biomarkers”, GlaxoSmithKline, March 10, King of Prussia, PA

2009 Invited speaker “Prevention of ovarian cancer peritoneal metastasis by designing blocking strategies of CA125/mesothelin interaction using natural or recombinant antibodies.” 6th Cancer Drugs R&D Conference. February 19-20, Philadelphia, PA.

2009 Invited speaker “The coming of age of ovarian cancer biomarkers.” 2nd Oncology Biomarkers Conference. Jan. 19-20, Miami, FL.


  1. Invited speaker “Using yeast for display and secretion of recombinant antibodies”, LifeSensors, Inc. October 28, Malvern, PA.

2008 Invited speaker “Selection of high affinity anti-TEM1 scFv by magnetic and flow sortings of a novel yeast-display scFv library”, Bracco Research USA Inc, September 25, Princeton, NJ.

2008 Invited speaker “Yeast-display scFv and biobodies”, Morphotek, Inc., July 14, Exton, PA.

2008 Invited speaker “Generation of libraries of recombinant llama heavy-chain for diagnostic and discovery of cancer markers”. Second International Conference on Ovarian Cancer: State of the Art and Future Directions, June 26 - July 1, Rhodes, Greece

2008 Poster presentation “Generation of recombinant libraries of heavy-chain V regions derived from Llama Glama”. Scholler N., Gross J.A. and Urban N. Canary Foundation Early Detection Symposium, May 21-22, Stanford, CA.

2007 Oral presentation “Development and in vitro Validation of anti-Mesothelin Biobodies that prevent CA125/Mesothelin-dependent Cell Attachment.”. Bergan L, Gross JA, Nevin B, Urban N and Scholler N. 15th SPORE Investigators’ Workshop Concurrent Poster Discussion SessionNew Technologies and Methodologies in Translational Research II, July 7-10, Baltimore, MA.

2007 Poster presentation “Development and in vitro validation of anti-mesothelin biobodies that prevent CA125/Mesothelin-dependent cell attachment.” Scholler N, Bergan L, Gross JA, Garvik B, Nevin B, and Urban N. Federation of Clinical Immunology Societies (FOCIS) annual meeting, June 7-11, San Diego, CA.

2007 Poster presentation “Generation of a new type of yeast-secreted biotinylated recombinant antibodies directed against mesothelin and able to prevent CA125/mesothelin-dependent cell attachment.”. Scholler N, Garvik B, Bergan L, Nevin B, Gross JA, and Urban N. ASGT 10th Annual Meeting, May 30 - June 3, Seattle, WA.

2007 Invited speaker “Design of new classes of recombinant antibodies and validation for use in cancer diagnostics and therapy.” University of Pennsylvania May 16, Philadelphia, PA.

2007 Poster presentation “Validation of in vivo-biotinylated yeast-secreted recombinant antibodies for use in diagnostic tests.” Scholler N, Lowe K, Bergan L, Kampani A, Gross JA, Garvik B and Urban N. - BioMarker World Congress 2007, May 15–17, Philadelphia, PA.

2006 Invited speaker Utilisation d'un test d'adhésion cellulaire basé sur l'interaction CA125/mésotheline pour tester in vitro de nouvelles voies d'approches thérapeutiques pour la prévention de micro-métastases péritonéales du cancer de l'ovaire.” Institut de Cancérologie et d'Immunologie de Marseille IFR 137 (Institute of Cancer and Immunology) INSERM UMR 599, November 15, Marseille, France.

2006 Invited speaker “Method for generation of in vivo biotinylated recombinant antibodies by yeast mating.” Laboratoire Technologies Avancées pour le Génome et la Clinique TAGC (Laboratory of Advanced Technology for Genome and Clinic) ERM 0206, November 14, Marseille –Luminy, France.

2006 Invited speaker “Generation of antigen-specific recombinant antibodies in the absence of purified and/or immunogenic antigens.” Seattle Biomedical Research Institute, November 6, Seattle, WA.

2006 Invited speaker “Generation of New Tools for Early Detection of Ovarian Cancer.” Complex Carbohydrate Research Center, University of Athens. September 29, Athens, Georgia.

2006 Oral presentation “Bead-Based ELISA Assays for Validation of Ovarian Cancer Early Detection Markers.” - Scholler N, Crawford M, Sato A, Drescher CW, O’Briant KC, Kiviat N, Anderson GL and Urban ND. Sixth Biennial Symposium sponsored by the MRCOCR, September 7-8, Seattle, WA.

2006 Oral presentation “Development of a CA125-Mesothelin Cell Adhesion Assay as a Screening Tool for Biologics Discovery.” Scholler N, Garvik B, Hayden-Ledbetter M, Kline T and Urban ND. Fourteenth SPORE Investigators’ Workshop Concurrent Plenary session, July 16-19, Baltimore MA.

2006 Poster presentation. “Biobodies: generation and validation.” Scholler, N. and Garvik, B. American Association of Immunologists, May 12–16, Boston, MA.

2005 Oral Presentation “Sandwich test ELISA with scFv antibodies: an alternative to an all-time favorite”- Scholler N, Garvik B and Urban N. Symposium of the Era of Hope Department of Defense Breast Cancer Research, Philadelphia, PA.

2004 Poster presentation “Generating New Tools for CD83 Functional Studies: Identification of an Anti-CD83 Recombinant Antibody that Binds to an HB15-Alternate Epitope” Hamel Y, Greenberg P and Scholler N. Twelfth International Congress of Immunology, Montreal, Canada.

2004 Oral presentation “Isolation of ovarian carcinoma-specific native proteins for development of new biomarkers.” Scholler N, Lampe P and Urban N. Eleventh SPORE Investigators Workshop, Baltimore, MD.

2002 Oral presentation “CD83 regulates the development of cellular immunity”. Scholler N, Hayden-Ledbetter M, Dahlin A, Hellström I, Hellström KE and Ledbetter JA. FASEB Immunology, New Orleans, LA.

2001 Oral presentation “CD83 is a adhesion receptor that binds monocytes and activated CD8+T cells” Scholler N, Disis ML, Dahlin A, Pullman J, Hellström KE and Hellström I. Eleventh International Congress of Immunology, Stockholm, Sweden.

2001 Oral presentation “HER2 DNA immunization with costimulatory molecules elicits functional anti-HER2 antibodies and CD4+ T cell tumor infiltration.” Scholler N, Ledbetter M., Hellström KE, Hellström I, Ledbetter JA - Eleventh International Congress of Immunology, Stockholm, Sweden.

2001 Oral presentation “HER2 DNA immunization with costimulatory molecules elicits functional anti-HER2 Antibodies.”. Scholler N, Disis ML, Dahlin A, Pullman J, Hellström KE and Hellström I - Fourth Annual Meeting of the ASGT, Seattle, WA. Abstract published in Molecular Therapy. 3(5): S69-70.

2001 Poster presentation “HER2 DNA immunization with costimulatory molecules”. Scholler N, Disis ML, Dahlin A, Pullman J, Hellström KE and Hellström I. Ninth SPORE Investigators Workshop, Washington, DC.

2000 Oral presentation “Antibodies to the HER2 protein can be elicited with DNA immunization.” Scholler N, Disis ML, Pullman J, Hellström KE and Hellström I - Third Biennial Ovarian Cancer Research Symposium, Seattle, WA.

1998 Oral presentation “DNA immunization with a combination of Rat Neu antigen, CD86 and 4-1BB ligand results in the generation of HER-2/neu (HER2) antibodies in Neu transgenic (neuT) mice.” Scholler N, Shiota FM, Pullman J, Hellström KE, Hellström I and Disis ML. Seventh International Conference on Gene Therapy of Cancer, Coronado, CA.



  1. Poster presentation “Mapping of CTLA4-CD28 genomic region by yeast artificial chromosomes (YAC).” Buonavista N, Balzano C, Pontarotti P, Le Paslier D and Goldstein P.- May 11-15, Workshop Genome mapping and sequencing, Cold Spring Harbor, NY.

1992 Invited speaker “Interest and advantage of YAC technology for genome mapping”- September 15, Workshop Pulse Field Electrophoresis, Pharmacia, France.

Abstracts

2012 “A novel anti-B7-H4 recombinant antibody overcomes TAMs-mediated T-cell inhibition.” Dangaj, D., Zhao, A., Lanitis, E., Joshi, S., Sandaltzopoulos, R., Powell Jr., D.J., and Scholler, N. Poster presentation, AAI 2012, May 4-8, Boston, MA.

2012 “Characterization of human B cells and macrophages infiltrating ovarian cancers.” Selene Nunez-Cruz, Marc Walter, Gwenn Danet-Desnoyers, Nathalie Scholler. Poster presentation, AAI 2012, May 4-8, Boston, MA.

2012 Phenotype and function of tumor-infiltrating macrophages and B cells in a novel humanized mouse model (NSG-HIS) for ovarian cancer”. Selene Nunez-Cruz, Marc Walter, Gwenn Danet-Desnoyers, Nathalie Scholler. Poster presentation, AACR Annual Meeting 2012, March 30-Apr 4, Chicago, IL.

2012 “MTBhsp70 Fusion Protein Targeting Mesothelin Augment Tumor Specific T Cell Responses and Prolong Survival in Murine Models of Ovarian Cancer”. Jianping Yuan, Pierre Leblanc, Satoshi Kashiwagi, Jean Nezivar, Elda Righi, Michael Santosuosso, Svetlana Korochkina, Sandra Orsuli2, Nathalie Scholler, Glenn Dranoff, Jeffrey Gelfand and Mark C. Poznansky. Poster presentation, AACR Annual Meeting 2012, Apr 2, Chicago, IL.

2012 “A novel anti-B7-H4 human recombinant antibody overcomes ovarian cancer polarized TAM-mediated TCR specific T-cell inhibition”. D. Dangaj, A. Zhao, E. Lanitis, S. Joshi, R. Sandaltzopoulos, D. J. Powell Jr, N. Scholler. Oral and poster presentations, Translational Research Cancer Centers Consortium conference 2012, February 22-24, Seven Springs, PA. Junior Investigator Research Award, D. Dangaj.

2011 “Blocking B7-H4- mediated T-cell inhibition to alter the tumor microenvironment”, Denarda Dangaj, Shree Joshi, Aizhi Zhao, Raphael Sandaltzopoulos and Nathalie Scholler. Poster presentation, 26th Annual Meeting of the Society for Immunotherapy of Cancer (SITC), November 4-6, 2011, Bethesda, MD.

2011 “Characterization of a TEM1 tumor-targeting antibody”. George Coukos, Aizhi Zhao, Chunsheng Li, Daniel Ricklin, Tamara Seedial, and Nathalie Scholler, Era of Hope 2011, Orlando, FL.

2011 “Developing magnetic nanoparticles for targeted nucleic acid delivery and detection” Poster presentation. Prantner A.M., Chen J., Murray C.B., and Scholler N. ASGCT 2011, May7 17-21, Seattle, WA.

2011 “B cells infiltrating ovarian cancer exhibit a regulatory-like phenotype.” Selene Nunez-Cruz, William J. Quinn III, Denise C. Connolly and Nathalie Scholler. Oral presentation, The Journal of Immunology, 2011 supplement, AAI 2011, May 13-17, San Francisco, CA. Travel Award, Selene Nunez-Cruz.

2011 “Mannose receptor regulates macrophage polarization in the tumor microenvironment” Denarda Dangaj, Shree Joshi, Aizhi Zhao, Raphael Sandaltzopoulos and Nathalie Scholler. Poster presentation, The Journal of Immunology, 2011 supplement, AAI 2011, May 13-17, San Francisco, CA.

2011 “Role of TLR engagement on TIL-B and clinical implications for ovarian cancer.” Selene Nunez-Cruz, Matthew Guerra, Denise Connolly, Phyllis Gimotty and Nathalie Scholler. Poster presentation, AACR 2011, April 2-5, Orlando, FL.

2011 “Developing targeted superparamagnetic iron oxides for combination chemohyperthermia” Prantner A.M., Chen J., Murray C.B., and Scholler N. Poster presentation, Immunochemotherapy: Correcting Immune Escape in Cancer, March 10, Philadelphia, PA.

2011 “Modeling the human tumor-microenvironment in CD34 transplanted NSG mice” Marc Walter, Selene Nunez-Cruz, Ananda Mookerjee, Chongyun Fang, Andrea Facciabene, George Coukos, Gwenn Danet-Desnoyers and Nathalie Scholler. Poster presentation, Immunochemotherapy: Correcting Immune Escape in Cancer, March 10, Philadelphia, PA.

2011 “Reconstitution of the human ovarian tumor-microenvironment in CD34-transplanted NOD-Scid-IL2Rc null (NSG) mice.” Marc Walter, Ananda Mookerjee, Selene Nunez-Cruz, Chongyun Fang, Andrea Facciabene, Daniel J. Powell Jr., George Coukos, Nathalie Scholler, and Gwenn Danet-Desnoyers. Poster presentation, Translational Research Cancer Centers Consortium conference 2011, February 24-26, Seven Springs, PA

2011 “Modulation of the tumor microenvironment by targeting the co-inhibitory B7H4 molecule”. Denarda Dangaj, Shree Joshi, Aizhi Zhao, Daniel J. Powell Jr., Raphael Sandaltzopoulos and Nathalie Scholler. Poster presentation, TRC3 2011, February 24-26, Seven Springs, PA

2010 “Characterization of scFv78: an anti-TEM1 scFv” Aizhi Zhao, Chunsheng Li, Daniel Ricklin, Tamara Seedial, George Coukos, Nathalie Scholler. International Society for Biological Therapy of Cancer (iSBTc). Poster presentation, October 2 - 4, Washington, D.C. The Journal of Immunotherapy, in press.

2010 “Targeting of superparamagnetic iron oxide nanoparticles for cancer therapy based on localized hyperthermia” Andrew M. Prantner, Jun Chen, Christopher B. Murray and Nathalie Scholler. 6th annual Symposium Center for Translational Medicine, oral and poster presentations, June 4, Jefferson Medical College, Philadelphia, PA

2010 “The binding of mannose receptor by tumor-released GPI-anchor proteins controls tumor-associated macrophage phenotype”, Denarda Dangaj, Selene Nunez-Cruz, Aizhi Zhao, Raphael Sandaltzopoulos and Nathalie Scholler. Oral presentation, CRRWH annual retreat, University of Pennsylvania, PA. Presentation winner, D. Dangaj.

2010 “Gold nanorods conjugated to tumor-specific antibody for the targeting of ovarian cancer” Kolin C. Hribar, Gregory R. Wiedman, Andrew Prantner, Chaitanya Divgi, and Nathalie Scholler. Senior Design project of undergraduate students in Bioengineering, poster presentation, April 20, University of Pennsylvania, School of Engineering, PA.

2010 “Ovarian tumor infiltrating lymphocytes B (TIL-B) present pro-angiogenic properties.” Selene Nunez-Cruz, Matthew Guerra, Denise Connolly, George Coukos, Phyllis Gimotty and Nathalie Scholler - The Journal of Immunology, 2010, 184, 101.7; AAI 2010, Poster and oral presentations. May 7-10, Baltimore, MD. Trainee Achievement Award, Selene Nunez-Cruz.

2010 “Comparative screening of human antibody libraries derived from autoimmune vs. cancer patients for affinity reagents directed against tumor-associated antigens”. Aizhi Zhao, Yi Cheng, George Coukos, Don Siegel, and Nathalie Scholler. - The Journal of Immunology, 2010, 184, 101.20 AAI 2010, Poster presentation. May 7-10, Baltimore, MD.

2010 “Tumor-released GPI-anchored proteins bind to mannose receptor and polarize tumor-infiltrating macrophages.” Denarda Dangaj, Aizhi Zhao, Selene Nunez-Cruz, Raphael Sandaltzopoulos and Nathalie Scholler - AACR 2010 Poster presentation. April 20, Washington, DC.

2010 “Genetic and pharmaceutical approaches for the study of complement factors as alternative therapy for ovarian cancer”. Selene Nunez-Cruz, Hongchang Qu, Stavros Rafail, Denise Connolly, Phyllis Gimotty, John Lambris, George Coukos, and Nathalie Scholler. - AACR 2010 Poster presentation. April 19, Washington, DC.




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