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Parham Taslimi
1
and Afsun Sujayev
2

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(phenylsulfonamido)-propanate (E3) with acetylacetone (pentane-2,4-dion)-2-carboxylate synthesized. The reaction is 
carried out in an aqueous medium according to the scheme: 
E1
E2
+
O
O
morpholin
E3
K
S
C
N
N
S
O
O
S
N
N
S
S
N
O
O
O
O
HN
S
O
O
S
N
O
O
Cl
O
O
H
N
S
O
O
N
S
O
O
Cl
Scheme. Synthesis of new rhodanides (E1-E3). 
In addition, the inhibitory effects of these compounds on acetylcholinesterase (AChE), α-glycosidase (α-Gly), 
human carbonic anhydrase I (hCA I), and human carbonic anhydrase II (hCA II) enzymes have been investigated. It has 
been seen that all compounds have a better ability to inhibit compared to existing tried inhibitors. Among these, the best 
inhibitor against AChE enzyme is E3 (Ki 52.07 µM and IC50 71.52), and against α-Gly, E2 showed the highest effect 
(Ki 1076.38 µM and IC50 994.37). The best inhibitor against hCA I, and hCA II enzymes is E3 compound. For hCA I 
and hCA II, IC50 values were calculated as 3.93 and 8.44 µM and Ki values were measured as 57.64 and 79.75 µM, 
respectively fort his compound. Molecular docking results have shown that the most active compounds have binding 
affinity with -4.423, -6.204, -6.623, and -6.298 kcal/mol against hCA I, hCA II, AChE, and α-glycosidase enzyme, 
respectively.