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References: 
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Mirziyoev Sh.M. Address of the Oliy Majlis of the President of the Republic of Uzbekistan 
Shavkat Mirziyoyev December 22, 2017 
2.
Decree of the President of the Republic of Uzbekistan dated September 21, 2018 No. PF-
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Websites. Lex.uz sites

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5th Global Congress on Contemporary Sciences & Advancements 
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10th May 2021 
 
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149
COMPARATIVE ASSESSMENT OF THE EFFECT OF OMEPRAZOLE 
AND PANTAPRAZOLE ON THE DEGREE OF DEVELOPMENT OF 
HEPATIC ENCEPHALOPATHY IN THE PATIENTS WITH LIVER 
CIRRHOSIS 
Bekmuradova Makhsuda Salkhidinovna,
Shodieva Gulzoda Rabimkulovna,
Yarmatov Suvon Totliboevich 
Samarkand State Medical Institute, Department of Propedeutics of Internal Diseases, 
Samarkand, Uzbekistan 
Introduction. Chronic liver disease is becoming one of the first places in terms of prevalence and 
is currently the fifth most common cause of death in many developed countries[2,3]. One of the 
manifestations associated with liver failure is hepatic encephalopathy syndrome, which is a 
dysfunction of the brain, which manifests itself in a wide range of neurological or psychiatric 
disorders from subclinical changes to coma [1,6,10]. Often, with cirrhosis of the liver due to 
portal hypertension against the background of pronounced venous stasis, the stomach and 
duodenum are affected [2,12]. Sometimes due to hemodynamic disturbances in the 
gastrointestinal tract with cirrhosis of the liver, ulcers are formed, the so-called hepatogenic 
ulcers [3,7]. In addition, chronic diseases of the liver and biliary tract are often combined with 
inflammatory and degenerative-dystrophic changes in the mucous membrane of the stomach and 
duodenum. In the genesis of the development of hepatogenic ulcers, a number of authors attach 
great importance to the acid-peptic factor [8,10]. Duodeno-gastric reflux is considered an 
important factor in the pathogenesis of gastric ulcer and duodenal ulcer in liver cirrhosis [11,12]. 
The development of duodenal ulcers in patients with cirrhosis of the liver can be associated with 
microcirculatory disorders of the gastric mucosa, stagnation of venous blood and functional liver 
failure [2,6,10]. This condition requires the use of PPIs in patients with cirrhosis of the liver and 
concomitant gastrointestinal lesions. In recent years, data have appeared in the literature that 
PPIs can worsen the degree of hepatic encephalopathy in patients with cirrhosis of the liver, and 
sometimes even can provoke the development of encephalopathy in this category of patients 
[4,6,9]. Recent studies have shown that these drugs cannot be used without clear indications, 
since a number of studies have demonstrated a clear relationship between PPIs and the 
development of conditions such as hepatic encephalopathy, osteoporosis, pneumonia, etc.[5,10]. 
And it has also been shown that PPIs work by suppressing acid, which can disrupt the gut 
microbiome, as a result of this, the concentration of ammonia in the blood can increase, that is, 
hyperammonemia [2,4,12]. 
Purpose of the study. To evaluate in a comparative aspect the effect of Omeprazole and 
Pantaprazole on the degree of development of hepatic encephalopathy in patients with cirrhosis 
of the liver accompanying with diseases of the gastrointestinal tract. 
Materials and research methods. The work was carried out at the Department of Propedeutics of 
Internal Diseases on the basis of the clinic SamMI №1 in the Department of 2-therapy. We 
examined 52 patients (24 women and 28 men) with liver cirrhosis (class A, B, C according to 

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5th Global Congress on Contemporary Sciences & Advancements 
Hosted from Singapore 
10th May 2021