Bachelor degree

Module designation	Module 4. General genetics and Biostatistics General and molecular genetics Biostatistics
Module level, if applicable	Basic professional modules
Code, if applicable	GMG 2412 BS 3413
Subtitle, if applicable	-
Courses, if applicable	Course		Credits
	General and molecular genetics		3 (2 lectures + 1 lab / week)
	Biostatistics		3 (1 lectures + 1 seminar+ 1 lab / week)
Semester(s) in which the module is taught	3 semester 6 semester
Person responsible for the module	Dr., Professor Shulembaeva G.K.
Lecturer	Dr., Professor Shulembaeva G.K., Candidate of Biological Science, Associate Professor Zhunisbaeva Zh.K.
Language	Kazakh, Russian, English
Relation to curriculum	(State/Social/ Vocational/IET) Vocational
Type of teaching, contact Hours	Lecture	Practicum		Seminars
	30 hours per semester 2 hours per week	15 hours per semester 1 hour per week		-
	15 hours per semester 1 hour per week	15 hours per semester 1 hour per week		15 hours per semester 1 hour per week
Workload	Lectures	Guided self-study		Self-study
	30 hours per semester 2 hours per week	-		60 hours per semester 4 hours per week
	15 hours per semester 1 hour per week	20 hours per semester		30 hours per semester 2 hours per week
Credit points	3 credits= 5 ECTS 3 credits= 5 ECTS
Requirements according to the examination regulations	It is necessary to have knowledge of basic sciences that underpin modern biotechnology, to understand the essence of advanced methods and technologies in the professional activity of the expert - Biotechnology
Recommended prerequisites	Plant Biodiversity, Animal Biodiversity, Low molecular weight biological molecules, Microbiology and Virology
Module objectives/intended learning outcomes	Knowledge	Skills		Competences
	Remember: the location of biometrics and the limits of its use in the biological research, basic statistical methods and concepts, terminology and symbols of biometrics; Understand: the basic laws of genetics and molecular mechanisms of inheritance of traits, genetic experiment to plan and solve genetic problems.	Apply: statistical analysis; Analysis: mathematical and statistical tables.		Evaluate: scientific experiment, analyze and process the results, make evidence-based conclusions on the basis of biometric data; Create: experiments with Drosophila; analyse results of basic research and genetic findings.
Content	The course will cover the following topics:
	General and molecular genetics (one hour for one lecture): 1. Subjects and Methods of Genetics. Categories of heredity and variability. 2. Branches of Genetics. Genetic objects. The history of Genetics. 3. The basic genetic concepts. Genetic symbols. 4. Monohybrid crossing. Mendel's laws for monohybrid crosses. The types of allelic genes interactions. 5. Di-and polyhybrid crosses. The third law of Mendel. 6. Principles of inheritance of polyhybrid crosses. The cytological basis of Mendel's laws. The general formula for the independent inheritance splitting. 7. The interaction between nonallelic genes. 8. The statistical nature of splitting. The chi-square test. Lethal genes. Modifier genes. 9. Sex determination and sex-linked inheritance. 10. Nondisjunction of sex chromosomes. Regulation of sex. 11. Linkage and crossing over. Genetic evidence of crossing over. 12. The genetic mapping of chromosomes. Regulation of crossing over. Chromosome theory of heredity. 13. Extra-nuclear inheritance. 14. Mobile elements of the genome. 15. Hereditary and non-hereditary variability. Mutation theory of Hugo de Vries. Classification of mutations. 16. Modifications and the rate of reaction. The Vavilov’s law of variability homologous series. 17. Genomic mutation. Chromosomal rearrangements. 18. Gene mutations. 19. Spontaneous and induced mutagenesis. Methods of study and accounting of mutations. 20. Physical factors of mutagenesis. Chemical mutagenesis. Biological factors of mutagenesis. 21. The molecular basis of heredity. 22. DNA replication. 23. Evolution of the gene understanding theories. The fine structure of the gene. Gene functions. 24. The genetic code. Mechanisms of transcription. Translation mechanisms. 25. DNA repair mechanisms. 26. Mobile genetic elements. 27. Methods of Human Genetics. Genetic structure of the population. Medical Genetics. 28. Genetic methods of selection process. Types of selection. Inbreeding. Heterosis. 29. Genetic engineering at the level of cells and organisms. 30. Clones and chimeras. Overview of the current state of biotechnology research in Kazakhstan
	Biostatistics: 1, 2. Concept of statistics, its significance, scope. 3, 4. Variability and methods of its study. 5, 6. Basic parameters characterizing the population. Statistical analysis of quantitative traits. 7, 8. The theory of representation. 9, 10. Statistical analysis of qualitative features. 11, 12. Correlation analysis. 13, 14, 15. Analysis of variability.
Study and examination requirements and forms of examination	1^st interim control: attendance, in-class discussion, problem solving, testing 2^nd interim control: attendance, in-class discussion, problem solving, testing Final examination: written, 2 theoretical questions, 1 practical question
Media employed	Video lectures, presentations
Reading list	References: Chencov J.C. Introduction in Genetics. M., MSU. 2005. 494p. (in russian) Shulembaeva G.K. Chromosomal engineering. Almaty. 2009. 234 p. (in kazakh), (in russian) Molitvin M.N., Harazova A.D. Cell and Molecular Biology. St-Petersburg. LSU. 1992. 314p. (in russian)