Bachelor degree

Module designation	Modules of Individual educational direction /traectory (IED) Molecular-genetical basics of Biotechnology
Module level, if applicable	Module of Individual Educational Trajectory 4: "Genetics technology"
Code, if applicable	MGBB 3504
Subtitle, if applicable	not applicable
Courses, if applicable	Course		Credits
	Molecular-genetic basics of Biotechnology		3
			2 lectures + 1 seminar / week
Semester(s) in which the module is taught	5 semester
Person responsible for the module	Dr., Prof. Aytasheva Z.G.
Lecturer	Dr., Prof. Aytasheva Z.G., Dr., Prof. Bissenbaev A.K.
Language	Kazakh, Russian, English
Relation to curriculum	(State/Social/ Vocational/IET) IET
Type of teaching, contact Hours	Lecture	Practicum		Seminars
	30 hours per semester (2 hours per week)	-		15 hours per semester (1 hour per week)
Workload	Lectures	Guided self-study		Self-study
	30 hours per semester (2 hours per week)	20 hours per semester		60 hours per semester (4 hours per week)
	Seminars
	15 hours per semester (1 hour per week)
Credit points	3 credits= 5 ECTS
Requirements according to the examination regulations	Awareness of modern methods of biotechnology, molecular and cellular mechanisms of genetic and cell engineering.
Recommended prerequisites	GMG 2412 General and molecular genetics
Module objectives/intended learning outcomes	Knowledge	Skills		Competences
	Basic principles and application of molecular biotechnology, polymorphism of length of restriction fragments, value of polygenic inheritance of traits, molecular diagnostics of genetic diseases, creation of cDNA libraries and genomic libraries, modern ideas of a structure and functions of proteins, basic principles of cellular engineering, allele-specific oligonucleotides in genetic screening, etc. Remember: Genetic bases of biotechnology; Understand: the principles and techniques of genetic transformation of somatic and germ cells of animals.	Electrophoresis of nucleic acids, methods of obtaining and analysis of cDNA, shotgun method. Apply: handling devices amplification, DNA sequencing and other laboratory equipment used in biotechnology; Analysis: PCR amplification of genes.		Ability to design experiments and conduct research on molecular genetics with the latest techniques. Evaluate: theoretical and practical knowledge for planning experiments; Create: service organization for protection of plants from pests and diseases, prepare projections of disease occurrence.
Content	The course will contain the following topics:
	Molecular-genetic basics of Biotechnology: 1. Molecular biotechnology as interdisciplinary science. Short history of development of molecular biotechnology. 2. Basic principles and application of molecular biotechnology. 3. Characteristic of genetic material. Straight lines and indirect proofs of a role of DNA in eukaryotic cells. 4. Methods of an electrophoresis of nucleic acids. 5. Mechanisms of synthesis of RNA. RNA-containing enzymes. 6. Analysis of genetic polymorphism. Mapping human genes. Polymorphism of length of restriction fragments (PDRF, RFLP). 7. Inheritance of quantitative traits. Value of polygenic inheritance of traits. Mapping of loci of quantitative traits. 8. Molecular diagnostics of genetic diseases. 9. Prenatal genotyping. Allele-specific oligonucleotides in genetic screening. 10. DNA sequencing. Types and stages of sequencing. 11. DNA cloning in E. coli cells, in eukaryotic cells. Extracellular cloning by means of the PTsR method. Methods of obtaining and analysis of cDNA. 12. Creation of cDNA libraries and genomic libraries. Extraction of the cloned genes from libraries, the characteristic of the cloned sequences. 13. Methods of genome analysis. "Clone behind a clone" method. Shotgun method. 14. Modern ideas of a structure and functions of proteins, their structures. Biotechnology of acellular systems of biosynthesis of protein. 15. Basic principles of cellular engineering. Characteristic of eukaryotic cells of plants and animals.
Study and examination requirements and forms of examination	1^st interim control: attendance, in-class discussion, problem solving, testing 2^nd interim control: attendance, in-class discussion, problem solving, testing Final examination: written, 2 theoretical questions, 1 practical question
Media employed	Flash and ppt presentations
Reading list	References (both in English): 1. Bruce Alberts et al. Molecular Biology of the Cell. – Garland Science, 2007, 1392 p. (in english) 2. Sandy B. Primrose, Richard Twyman. Principles of Gene Manipulation and Genomics. – Wiley-Blackwell, 2006, 672 p. (in english)
Module designation	Modules of Individual educational direction /traectory (IED) Radiation genetics
Module level, if applicable	Module of Individual Educational Trajectory 4: "Genetics technology"
Code, if applicable	RG 3505
Subtitle, if applicable	not applicable
Courses, if applicable	Course		Credits
	Radiation genetics		3
			2 lectures + 1 seminar / week
Semester(s) in which the module is taught	6 semester
Person responsible for the module	Candidate of Biological Science, Assoc. Prof. Chunetova Zh.Zh.
Lecturer	PhD, Assoc. Prof. Chunetova Zh.Zh., PhD, Assistant Prof. Zhussupova A.I., PhD, Assistant Prof. Altynova N.К.
Language	Kazakh, Russian, English
Relation to curriculum	(State/Social/ Vocational/IET) IET
Type of teaching, contact Hours	Lecture	Practicum		Seminars
	30 hours per semester (2 hours per week)	-		15 hours per semester (1 hour per week)
Workload	Lectures	Guided self-study		Self-study
	30 hours per semester (2 hours per week)	20 hours per semester		60 hours per semester (4 hours per week)
	Seminars
	15 hours per semester (1 hour per week)
Credit points	3 credits= 5 ECTS
Requirements according to the examination regulations	The impact of ionizing radiation, UV rays, basic chemical mutagens on a living organism. Methods of mutational processes research and their applications in genetics, plant breeding and biotechnology, as well as the application of their advances in medicine, agriculture and biology.
Recommended prerequisites	GMG 2412 General and molecular genetics
Module objectives/intended learning outcomes	Knowledge	Skills		Competences
	Impact of radiation on different types of organisms, including human, factors, modifying efficiency of ionizing radiation on hereditary structures, mechanisms of formation of radiation damages of DNA, characteristics and features of emergence of point mutations, indirect action of ionizing radiation, biological markers of radiation. Remember: the impact of radiation studies on the formation of modern genetics as a science; Understand: mutagenic and carcinogenic effects of radiation exposure.	Minisatellite analysis, analysis of chromosome abberations. Apply: theory and applied aspects of the mutation and radiation processes; Analysis: the genetic basis of their impact on the environment and internship.		Ability to design experiments and conduct research on molecular genetics with the latest techniques. Evaluate: the mechanism of action of radiation on biological objects; Create: the foundation to use the methods of radiation genetics in genetics, plant breeding and biotechnology, to use the achievements of radiation genetics in medicine, agriculture and biology.
Content	The course will contain the following topics:
	Radiation genetics: 1. Main stages of development of radiation genetics. 2. Radiosensitivity of cells at different stages of life cycle. 3. Factors, modifying efficiency of ionizing radiation on hereditary structures. 4. Concept of a doubling dose of radiation. 5. Impact of radiation on different types of organisms, including human. 6. Mechanisms of formation of DNA radiation damages. 7. Characteristic and features of emergence of point mutations. 8. Indirect action of ionizing radiation – action of free radicals, etc. 9. Biological markers of radiation influence. 10. Culture of lymphocytes of human peripheral blood as test system for assessment of a degree of environment mutagenicity. 11. Minisatellite analysis. 12. Final radio genetic effects. 13. Remote consequences of radiation. 14. Mechanisms of reparation of genetic material. 15. Individual radio sensitivity and genes candidates of radio sensitivity
Study and examination requirements and forms of examination	1^st interim control: attendance, in-class discussion, problem solving, testing 2^nd interim control: attendance, in-class discussion, problem solving, testing Final examination: written, 2 theoretical questions, 1 practical question
Media employed	Flash and ppt presentations
Reading list	References (all in English): William J. Schull. Effects of Atomic Radiation: A Half-Century of Studies from Hiroshima and Nagasaki. – Wiley-Liss, 1995, 416 p. (in english) 2.Sami Qutob. Characterization of Human Cell Lines with Different 3.Radiosensitivities: The Generation of a Model System for Distinguishing the Genetic Factors involved in Radiation Resistance Paperback – August 24, 2009. - LAP Lambert Academic Publishing, 2009, 328 p. (in english) Cytogenetic Analysis for Radiation Dose Assessment. Intl Atomic Energy Agency, 2002, 136 p. (in english)
Module designation	Modules of Individual educational direction /traectory (IED) Basics of genetics analysis
Module level, if applicable	Module of Individual Educational Trajectory 4: "Genetics technology"
Code, if applicable	BGA 3306
Subtitle, if applicable	not applicable
Courses, if applicable	Course		Credits
	Basics of genetics analysis		3
			2 lectures + 1 lab / week
Semester(s) in which the module is taught	6 semester
Person responsible for the module	PhD, Assoc. Prof. Dzhansugurova L.B.
Lecturer	PhD, Assoc. Prof. Dzhansugurova L.B., PhD, Assoc. Prof. Zhunusbaeva Zh.K.
Language	Kazakh, Russian, English
Relation to curriculum	(State/Social/ Vocational/IET) IET
Type of teaching, contact Hours	Lecture	Practicum		Seminars
	30 hours per semester (2 hours per week)	15 hours per semester (1 hour per week)		-
Workload	Lectures	Guided self-study		Self-study
	30 hours per semester (2 hours per week)	15 hours per semester (1 hour per week)		60 hours per semester (4 hours per week)
Credit points	3 credits= 5 ECTS
Requirements according to the examination regulations	Current understanding of the molecular genetics control of all phases of development in ontogeny after oocyte maturation and research on the combination of features of the body; genes that control the development of the Drosophila mutations and their mechanism of action and to introduce students to the genetics of the fruit fly and achievements in the field of experimental embryology and modern molecular biology.
Recommended prerequisites	GMG 2412 General and molecular genetics
Module objectives/intended learning outcomes	Knowledge	Skills		Competences
	Genetic aspects of individual development of living organisms, molecular genetics of control of all phases of development in ontogeny after oocyte maturation and research on the combination of features of the body, genes that control the development, etc. Remember: basic rules for working with the object of genetic research - the fruit fly; Understand: the molecular genetics control of all phases of development in ontogeny.	Modern methods of molecular biology. Apply: knowledge gained in the study of the discipline; Analysis: solving problems in the study of individual development of organisms and study the basic genetic patterns.		Ability to design experiments and conduct research on genetic analysis with the latest techniques. Evaluate: data for solving issues within the study of individual development of organisms and the study of the basic genetic laws; Create: experiments with the object of genetic studies Drosophila.