Webster's New World Medical Dictionary

lesbian
A female homosexual.
Leigh’s disease
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lesbianism
Female homosexuality. Also known
as Sapphism.
Lesch-Nyhan syndrome
A rare, inherited disor-
der caused by a deficiency of the enzyme hypoxan-
thine-guanine phosphoribosyltransferase (HPRT).
The lack of HPRT causes a buildup of uric acid in all
body fluids, and leads to symptoms such as severe
gout, poor muscle control, and moderate retarda-
tion, which appear in the first year of life. Affected
individuals also display self-mutilating behaviors
such as lip and finger biting, beginning in the sec-
ond year of life. Elevated uric acid levels can dam-
age many organs, including the joints, kidneys,
central nervous system, and other tissues of the
body, leading to swelling in the joints and severe
kidney disease. Neurological symptoms include
facial grimacing, involuntary writhing, and repetitive
movements of the arms and legs. The prognosis is
poor, with death usually occurring in the first or
second decade of life.
lesion
An area of abnormal tissue change.
Lesions vary in severity from harmless to serious.
let-down reflex
An involuntary reflex during
breastfeeding that causes the milk to flow freely.
lethal
Deadly.
lethal gene, zygotic
See 
gene, zygotic lethal.
lethargy
Abnormal drowsiness, stupor.
Letterer-Siwe disease
A form of Langerhans
cell histiocytosis starting in infancy that involves
proliferation of histiocytes in multiple organs such
as the skin, bones, and other organs. Symptoms
include rash, swollen glands, enlargement of the
liver and spleen, liver disease, anemia, and lytic
lesions of the bones. Letterer-Siwe disease is the
most severe form of Langerhans cell histiocytosis
and has a high mortality rate.