The ministry of education named after mirzo ulugbek national

Research results of practical significance and application: F-18, F-37 izoxinolin alkaloids such as a combination of aortic blood vessels cells, ion channels with ta‘secret features description of them from among of the heart, blood -vessels, diseases of , treatment and prevention get to new, potential pharmacological active to be able to medicinal tools in the creation of the prospects separated get the opportunity to gives

Scientific leader: b.f.n, assoc. T. Adilbekov

Scientific consultant: b.f.d, was. P. B. Usmanov

Master's student: D. SH.Shokirova

CONTENTS

List of abbreviations ...................................................................................................................

ACCESS ..............................................................................................

1. CHAPTER. LITERATURE ANALYSIS ...............................................

1.1. Structure and functions of smooth muscles .............................

1.2. Structure of smooth muscles ..................................................

1.3. Fiber cells of smooth muscle ion channels ............................

1.3.1. Smooth muscle fiber cells of the Sa 2+ -channels ....................

1.3.2. Fiber cells of smooth muscle K+ –channels ....

1.4. The contraction of smooth muscle fiber cells and the mechanism bo'shasha .....

1.4.1. Reduction of the molecular mechanisms of smooth muscles of the chamber ..............

1.4.2. The molecular mechanisms that relax the smooth muscles of the chamber ...............

1.4.3. Bo'shasha associated smooth muscles of the process to endoteliyga ........

1.5. The surge of alkaloids and features them................

I AM ON THE CHAPTER SUMMARY .....................................................

CHAPTER II. MASKIN CLONAL AND METHODS ..............................................

2.1. Research facilities .......................................................................

2.2. From the aorta of rats to note the activities of the preparation of the drug and its contraction. ......

2.2. Experience general scheme. Giperkaliyli indutsirlovchi qisqaruvchi of infringement of reaction solution....

2.3.Efforts to reduce Fenilefir bilanchaqirilgan............................

2.4. Statistical analysis of the obtained results ...................................

CHAPTER II SUMMARY ....................................................

CHAPTER III. RESULTS AND ANALYSIS ...................

3.1. Reaction of the aorta of rats with the drug in solution is called to diminish giperkaliyli

3.2. F-18, f-37 izoxinolin alkaloid of the aorta of rats in the drug KCl

indutsirlovchi effects qisqaruvchanlikka. ..................................................

CHAPTER III SUMMARY ....................................................................

RESULTS .................................................................................................

THE LIST OF USED LITERATURE ........................