Sirdarya Region (Uzbek: Sirdaryo viloyati, Сирдарё вилояти) is one of the regions of Uzbekistan, located in the center of the country on the left bank of Syr Darya River. It borders with Kazakhstan, Tajikistan, Tashkent Region, and Jizzakh Region. It covers an area of 5,100 km², and is mostly desert, with the Starving Steppe taking up a significant part of the region's area. The population is estimated to be around 648,100.
Syrdaryo Region is divided into 9 administrative districts. The capital is the city of Guliston (pop. est. 54,000 inhabitants). Other cities and towns include Baxt, Boyovut, Farhod, Qahramon, Sayhun, Sirdaryo, Shirin and Yangiyer.
The climate is a typically arid continental climate with extreme differences between winter and summer temperatures.
The economy is based on cotton and cereal crops, with strong reliance on irrigation and on cattle breeding. Minor crops include forage plants, vegetables, melons, gourds, potatoes, maize, a variety of fruit and grapes. Industry consists of construction materials, irrigation equipment and raw-cotton processing.