Schneiderman Prelims Vol-I. qxd

IRIS LESIONS, PIGMENTED
AUTOIMMUNE DISORDERS, AND DISEASES
OF IMMUNE DYSFUNCTION
Scleroderma – periorbital linear scleroderma associated with
heterochromic iridis 
Am J Ophthalmol 90:858–861, 1980
INFECTIONS AND INFESTATIONS
Leprosy – leproma
Syphilis – papulat of secondary or tertiary lues
INFILTRATIVE DISEASES
Juvenile xanthogranuloma – iris heterochromia Eye and Skin
Disease, pp.56–57, Lippincott, 1996
INFLAMMATORY DISEASES
Sarcoidal iris granuloma 
Clin Dermatol 4:129–135, 1986
NEOPLASTIC DISEASES
Aniridia with associated Wilms’ tumor
Benign epithelial melanosis
Conjunctival nevus
Iris freckles
Leiomyoma 
Rook p.3007, 1998, Sixth Edition
Melanocytic nevus
Melanoma 
AD 139:1067–1073, 2003
Melanosis oculi
Metastatic melanoma
Iris nevus
Nevus of Ota 
Dermatol Clin 10:609–622, 1992
Pigmented episcleral spot (Axenfeld’s nerve loop) 
Primary acquired melanosis
SYNDROMES
Aniridia with chromosome 18 defects
Cat eye syndrome – iris coloboma with trisomy 22
Down’s syndrome – hypoplastic iris with lighter areas in the
outer third (Brushfield spots) 
Rook p.373, 1998, Sixth Edition
Incontinentia pigmenti – conjunctival pigmentation
JAAD 47:169–187, 2002
Iris coloboma
4p deletion syndromes
Cat eye syndrome
Chromosome 18 defects (including trisomy 18) 
Focal dermal hypoplasia
Linear nevus sebaceus syndrome
Trisomy 22
Iris nevus syndrome (Cogan–Reese syndrome) 
Nail–patella syndrome – cloverleaf iris (Lester iris) 
Rook
p.421, 1998, Sixth Edition
Neurofibromatosis – Lisch nodule 
NEJM 343:1573, 2000; Rook
p.379, 1998, Sixth Edition; NEJM 324:1264–1266, 1991; J Med
Genet 26:712–721, 1989; Am J Ophthalmol 96:740–742, 1983