Schneiderman Prelims Vol-I. qxd

METABOLIC
Acrodermatitis enteropathica 
Textbook of Neonatal
Dermatology, p.254, 2001; Rook p.3167, 1998, Sixth Edition;
acquired zinc deficiency
Calcinosis cutis – calcified intertrigo 
Ann DV 122:789–792,
1995; JAAD 8:103–106, 1983; plaque-type intertriginous
calcinosis cutis 
Cutis 49:289–291, 1992
Cystic fibrosis
Essential fatty acid deficiency – severe xerosis with underlying
erythema, hair loss with hypopigmentation, and weeping
intertrigenous rash 
Ped Derm 16:95–102, 1999
Kwashiorkor – crusting and superficial erosions in the diaper
area 
AD 137:630–636, 2001; Ann DV 113:657–659, 1977
Maple syrup urine disease
Miliaria
Multiple carboxylase deficiency (biotin-responsive) – pyruvate
carboxylase, propionyl-coenzyme A carboxylase, and
3-methylcrotohyl-CoA carboxylase; accumulation of urinary
organic acids; neonatal – holocarboxylase synthetase
deficiency; juvenile or late-onset from – biotinidase deficiency –
erythematous scaly eruption interdigital webs, groin, axillae
Ped Derm 21:231–235, 2004; Ped Derm 16:95–102, 1999;
Adv Pediatr 38:1–21, 1991; AD 123:1696–1698, 1987
Riboflavin deficiency – component of coenzymes flavin
mononucleotide, and flavin-adenine dinucleotide involved
in oxidative phosphorylation; deficiency produces dermatitis
similar to glucagonoma syndrome with a prominent
periorificial component; angular stomatitis which often
bleeds, vertical fissuring of lips, smooth magenta tongue,
seborrheic dermatitis-like rash, scrotal dermatitis; riboflavin
deficiency seen in hypothyroidism, acute boric acid ingestion,
chlorpromazine use and neonatal phototherapy for
hyperbilirubinemia 
Semin Derm 10:293–295, 1991;
JAAD 21:1–30, 1989
Xanthomas, eruptive 
Ghatan p.66, 2002, Second Edition
NEOPLASTIC
Acrochordons with acanthosis nigricans
Basal cell carcinoma – red plaque in inguinal crease; shiny pink
axillary plaque 
Derm Surg 27:966–968, 2001
Bowen’s disease
Epidermal nevus – intertrigenous and perigenital
Extramammary Paget’s disease – the clinical picture of Paget’s
disease may change daily and may even become subclinical;
underlying adnexal carcinoma or carcinoma of the rectum,
urethra, cervix, or distant carcinoma of the breast 
JAAD
51:492–493, 2003; Sem Cut Med Surg 21:159–165, 2002;
unilateral axillary Paget’s disease 
J Dermatol 25:260–263, 1998;
Plast Reconstr Surg 100:336–339, 1997; AD 127:1243, 1991;
red plaque of inguinal crease and scrotum
BJD 153:676–677,
2005
ILVEN – intertrigenous and perigenital
Kaposi’s sarcoma
Lentiginosis profusa – intertrigenous pigmentation
Lymphoma – cutaneous T-cell lymphoma with axillary intertrigo;
poikiloderma vasculare atrophicans with CTCL
Melanoma 
JAAD 51:492–493, 2003
Metastatic gastric carcinoma – condyloma-like lesions in axilla
and groin 
Pathology of Unusual Malignant Cutaneous Tumors,
New York, Marcel Dekker pp.357–397, 1985
Porokeratosis 
BJD 140:553–555, 1999; BJD 132:150–151, 1995
Syringomas