Schneiderman Prelims Vol-I. qxd

NEOPLASTIC DISEASES
Melanoma – leukoderma; hypopigmented hair
PRIMARY CUTANEOUS DISEASES
Albinism – tyrosinase negative (type IA), yellow mutant (type
IB), platinum, tyrosinase positive (type II), minimal pigment,
brown, rufous, Hermansky–Pudlak syndrome – hypopigmented
skin and hair 
JAAD 19:217–255, 1988
Albinoidism 
JAAD 19:217–255, 1988
Alopecia areata – white (hair) overnight 
AD 102:162–167, 1970
Canities 
Rook p.2962, 1998, Sixth Edition
Diffuse hypomelanosis of scalp hair
Book syndrome
Chronic protein loss or deficiency (kwashiorkor, renal
disease, inflammatory bowel disease, malabsorption) 
Down’s syndrome
Fanconi syndrome
Hallerman–Streiff syndrome
Hyperthyroidism
Prolidase deficiency
Treacher Collins syndrome
Vitamin B
12
deficiency
Vitiligo
White forelock – isolated finding
SYNDROMES
Ataxia telangiectasia 
JAAD 42:939–969, 2000;
AD 134:1145–1150, 1998; JAAD 10:431–438, 1984
Book’s syndrome – autosomal dominant; premature graying,
premolar hypodontia, palmoplantar hyperhidrosis 
Am J Hum
Genet 2:240–245, 1950
Chediak–Higashi syndrome – autosomal recessive 
Curr Prob
Dermatol 18:93–100, 1989
Cri-du-chat syndrome (chromosome 5p syndrome) 
J Pediatrics
77:782–791, 1970
Cross syndrome – autosomal recessive; gingival fibromatosis,
microphthalmia with cloudy corneas, mental retardation,
spasticity, growth retardation, athetosis, hypopigmentation,
silvery gray hair 
Ped Derm 18:534–536, 2001; J Pediatr
70:398–406, 1967
Down’s syndrome – hypopigmented hair; vitiligo 
Ghatan p.69,
2002, Second Edition
Elejalde syndrome (neuroectodermal lysosomal disease) –
bronze skin, silver hair 
AD 135:182–186, 1999
Fanconi’s syndrome – hypopigmented hair 
Ghatan p.69, 2002,
Second Edition
Fisch’s syndrome – hypopigmented hair 
Ghatan p.69, 2002,
Second Edition
Griscelli syndrome (partial albinism with immunodeficiency) –
rare and fatal immunologic disorder characterized by partial
oculocutaneous albinism, silver gray sheen of the hair
(microscopic examination of hair shafts demonstrated large
pigment granules accumulated in the medullary region), and
variable cellular and immunodeficiency. Between the ages of
4 months and 4 years patients experience recurrent disease –
exacerabation of lymphohistiocytic infiltration of multiple organs,
including the brain and meninges often triggered by infection
J Ped 125:886, 1994
Hallerman–Streiff syndrome – hypopigmented hair 
Ghatan p.69,
2002, Second Edition
Hereditary premature canities
Hermansky–Pudlak syndrome – white skin and hair
AD 135:774–780, 1999
Hypomelia, hypotrichosis, facial hemangioma syndrome
(pseudothalidomide syndrome) – sparse silvery blond hair
Am J Dis Child 123:602–606, 1972
Lipoatrophy (distal), stunted growth, muscle cramps, and
hypoplastic uterus 
Rinsho Shinkeigaku 23:867–873, 1983
Menkes’ kinky hair syndrome – hypopigmented hair 
Rook
p.2965, 1998, Sixth Edition