Schneiderman Prelims Vol-I. qxd

INFILTRATIVE DISEASES
Amyloidosis – primary systemic 
Rook p.2634, 1998,
Sixth Edition
Scleromyxedema
INFLAMMATORY DISEASES
Atypical neutrophilic infiltrate – appearance in lymphedematous
extremity 
Dermatologica 183:230–233, 1991
Crohn’s disease – facial edema; scrotal edema, erythema, and
fistulae 
JAAD 36:697–704, 1997; vulvar edema with
lymphangiectasias 
Genitourin Med 65:335–337, 1989
Eosinophilic fasciitis – presenting as pitting edema of the
extremities 
Am J Med 111:318–320, 2001
Erythema induratum (Whitfield) – nodules with edematous
ankles 
Rook p.2207, 1998, Sixth Edition
Inflammation – secondary lymphedema
Lymphangitis – secondary lymphedema
Neutrophilic eccrine hidradenitis – localized edema 
Arch
Ophthalmol 112:1460–1463, 1994
Panniculitis
Sarcoid – lymphedema; unilateral leg edema 
JAAD
44:725–743, 2001
METABOLIC DISEASES
Anasarca – edema of breast 
Rook p.3160, 1998, Sixth Edition
Beriberi (Vitamin B
1
, thiamine deficiency) – anorexia, weakness,
constipation, polyneuritis, cardiac failure with edema, muscle
wasting 
JAAD 21:15–18, 1989
Cardiac disease 
Rook p.2287, 1998, Sixth Edition; edema of
breast 
Rook p.3160, 1998, Sixth Edition
Crohn’s disease – edema of prepuce and scrotum
JAAD:S182–183, 2003
Cryofibrinogenemia – of dorsal feet 
Am J Med 116:332–337, 2004
Diabetes – cold, swollen, dry feet 
Rook p.2231,2265,2675,
1998, Sixth Edition
Fabry’s disease (angiokeratoma corporis diffusum) – edema of
hands, arms, eyelids 
AD 140:1526–1527, 2004
Hartnup’s disease – edema due to hypoproteinemia and liver
disease 
Pediatrics 31:29–38, 1963
Heavy chain disease (Franklin’s disease) – palatal edema 
AD
124:1538–1540, 1988
Hemochromatosis, neonatal 
AD 132:1507–1512, 1996
Hemophagocytic syndrome – facial edema 
AD 128:193–200,
1992
Hypoalbuminemia
Hypoparathyroidism – puffy skin 
JAAD 17:921–940, 1989
Hypothyroidism – edematous and indurated skin 
Rook p.2513,
1998, Sixth Edition
Kwashiorkor 
JAAD 52:S69–72, 2005; AD 137:630–636, 2001;
Cutis 67:321–327, 2001; facial edema AD 134:107–108, 1998
Liver disease, chronic
Menstruation 
Rook p.2247, 1998, Sixth Edition
Myxedema – also massive localized lymphedema of
hypothyroidism 
Hum Pathol 31:1162–1168, 2000
Nephrogenic fibrosing dermopathy – presenting with anasarca
JAAD 48:55–60, 2003
Nephrotic syndrome or other forms of chronic renal disease
Rook p.2247, 1998, Sixth Edition; edema of breast Rook
p.3160, 1998, Sixth Edition
Oast house disease – white hair, recurrent edema; increased
serum methionine 
Rook p.2965, 1998, Sixth Edition
Obesity – pendulous abdomen with edema due to
lipodermatosclerosis 
Clin Exp Dermatol 18:164–166, 1993
Porphyrias – erythropoietic protoporphyria; acute facial edema
Eur J Pediatr 159:719–725, 2000; J Inherit Metab Dis
20:258–269, 1997; BJD 131:751–766, 1994; Curr Probl
Dermatol 20:123–134, 1991; Am J Med 60:8–22, 1976
Pregnancy 
Rook p.2247, 1998, Sixth Edition
Pretibial myxedema – solid non-pitting edema of shins and feet;
elephantiasic form with edema and nodule formation 
Rook
p.2707, 1998, Sixth Edition
Prolidase deficiency – autosomal recessive; skin spongy
and fragile with annular pitting and scarring; leg ulcers;
photosensitivity, telangiectasia, purpura, premature graying,
lymphedema 
Ped Derm 13:58–60, 1996; AD 127:124–125, 1991
Scurvy – peripheral edema 
JAAD 41:895–906, 1999
Sickle cell disease – hand-foot syndrome; edema of hands and
feet due to underlying bone infarction 
Clin Pediatr 20:311–317,
1981